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The map label for this gene is mutB [H]

Identifier: 119716359

GI number: 119716359

Start: 2277031

End: 2277549

Strand: Direct

Name: mutB [H]

Synonym: Noca_2128

Alternate gene names: 119716359

Gene position: 2277031-2277549 (Clockwise)

Preceding gene: 119716356

Following gene: 119716360

Centisome position: 45.67

GC content: 64.74

Gene sequence:

>519_bases
GTGTTACCTAAGGTAGGACCACATATGTGGCACACGCCACAGGCCAACCTAGGAGCCCCCATGCCGCTGTCCGCACACTC
CGACATCGACGCAGGCGACACCGCTCCGATCCGCATCATGCTCGCTAAGATCGGTCTCGACGGGCACGATCGAGGCGTCA
AGGTCGTCGCCCGCACACTGCGTGACGCCGGCATGGAGGTCGTCTACACCGGCCTTCACCGCAGCCCAGAGCAGGTCCTC
GAAGCCGCCGTGCAAGAAGACGTCGACGTGCTCGGCATCAGCCTGCTCTCCGGAGCACACCTGACCATTTTCGGTCGACT
CTTCACGCTCATCGCAGATCTTCCCTACACGCCACGATTTGCCGTCGTCGCTGGCGGCGTCATGCCCGACGAGGACGAGA
GGACCCTGATCGAACTGGGTGTCGCCGCTGTCCTCGGCCAGGACACCGCGCCGCGCCACATCGTCGAGGTCGTCACCGAC
GCCGCGAACCAGGCCCGGAACCAGGTAGAGGCCTCGTGA

Upstream 100 bases:

>100_bases
GAACCGGCCACAGCGCTCTCCACTTCGGTCGAAGGTCGGCTGGGGGCCGACACGCCCATCAAGAATAGTGATTCTTTATA
ACTTCTTGCGGAGTGCGAGT

Downstream 100 bases:

>100_bases
GCCTCAAGCAACCGCTCGAAGACTGGAAGTGGCCACCGTCGTACGACGACACCTACCTGCCCGCTAATAACGACCAGCCG
TACTGGTTTCCAATTCGAGA

Product: cobalamin B12-binding domain-containing protein

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MLPKVGPHMWHTPQANLGAPMPLSAHSDIDAGDTAPIRIMLAKIGLDGHDRGVKVVARTLRDAGMEVVYTGLHRSPEQVL
EAAVQEDVDVLGISLLSGAHLTIFGRLFTLIADLPYTPRFAVVAGGVMPDEDERTLIELGVAAVLGQDTAPRHIVEVVTD
AANQARNQVEAS

Sequences:

>Translated_172_residues
MLPKVGPHMWHTPQANLGAPMPLSAHSDIDAGDTAPIRIMLAKIGLDGHDRGVKVVARTLRDAGMEVVYTGLHRSPEQVL
EAAVQEDVDVLGISLLSGAHLTIFGRLFTLIADLPYTPRFAVVAGGVMPDEDERTLIELGVAAVLGQDTAPRHIVEVVTD
AANQARNQVEAS
>Mature_172_residues
MLPKVGPHMWHTPQANLGAPMPLSAHSDIDAGDTAPIRIMLAKIGLDGHDRGVKVVARTLRDAGMEVVYTGLHRSPEQVL
EAAVQEDVDVLGISLLSGAHLTIFGRLFTLIADLPYTPRFAVVAGGVMPDEDERTLIELGVAAVLGQDTAPRHIVEVVTD
AANQARNQVEAS

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=124, Percent_Identity=39.5161290322581, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1789284, Length=112, Percent_Identity=41.0714285714286, Blast_Score=79, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25144500, Length=135, Percent_Identity=40, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 18324; Mature: 18324

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKVGPHMWHTPQANLGAPMPLSAHSDIDAGDTAPIRIMLAKIGLDGHDRGVKVVARTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCCHHHHHHHHHH
RDAGMEVVYTGLHRSPEQVLEAAVQEDVDVLGISLLSGAHLTIFGRLFTLIADLPYTPRF
HHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCH
AVVAGGVMPDEDERTLIELGVAAVLGQDTAPRHIVEVVTDAANQARNQVEAS
HEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLPKVGPHMWHTPQANLGAPMPLSAHSDIDAGDTAPIRIMLAKIGLDGHDRGVKVVARTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCCHHHHHHHHHH
RDAGMEVVYTGLHRSPEQVLEAAVQEDVDVLGISLLSGAHLTIFGRLFTLIADLPYTPRF
HHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCH
AVVAGGVMPDEDERTLIELGVAAVLGQDTAPRHIVEVVTDAANQARNQVEAS
HEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]