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The map label for this gene is merA [H]

Identifier: 119716304

GI number: 119716304

Start: 2218202

End: 2219578

Strand: Reverse

Name: merA [H]

Synonym: Noca_2073

Alternate gene names: 119716304

Gene position: 2219578-2218202 (Counterclockwise)

Preceding gene: 119716305

Following gene: 119716289

Centisome position: 44.52

GC content: 73.35

Gene sequence:

>1377_bases
GTGACCGGGCCGACGACCCGGGCCGACATCGTGGTGGTCGGCATGGGTGTCGGTGGCGAGGCCGTCGCCGGCTCCCTCGC
CGAGGCCGGTCTCGACGTGGTCGGCATCGAGGCCGAGCTTGTCGGCGGCGAGTGCCCCTACTGGGGTTGCATCCCCAGCA
AGATGATGATCCGCGCGGCCAACCTGATCGCCGAGGCGAGCCGGATCCCCGGCATGTCCGGCACCGTCGACGTACGACCC
GACTGGACGCCGGTCGCCGACCGGATCCGCCACGAGGCCACCGACGACTGGAACGACCAGGTCGCCGTCGACCGATTCAC
CGGCAAGGGGGGCCGCTTCGTGCGCGGCGCGGCGACCGTCCTGGGGCCCCGCAGCGTGTCCGTCGAGGGCGTCGGCGTGA
TCGAGGCGCGGCGTGGGATCGTGCTCGCCACCGGCACCAGCTCGGTCGCGCCGCCCATCGACGGGCTGGCGGACACGCCG
TTCTGGACGAACCGCGAGGCGGTCAGCGCCAAGGACCTGCCCGCCTCCCTCGTCGTCCTCGGCGGCGGCGCGATCGGCGT
GGAGATCGGCCAGGCCTTCGCCCGGTTCGAGGTGGAGGTCACGGTCGTCGAGGCAGCCGAACGCATCCTGCCGGCCGAGG
AGCCGGAGGTGTCCGCGCTGCTGGCAGACACCTTCCGATCCGAGGGGATCACCGTCCTTGCCGGCCGAGCTGCCACCCAG
GTCGGCTACGCCGGCGGTACGTTCGCGATCCGGCTCGACAACGGTGACGATGTCACCGCGGAAGGGCTGCTGGTCGCCAC
CGGCCGGCGGCCGCAGGTCGCACCCGAGATGCTCCGGGCCCTCGAGCTCGAACCGGGCCTGCGGGCCCTGCCGGTCGATG
AGCGGATGCGGGTCGCGGACGGGGTCTGGGCGGTCGGCGACGTCACCGGCAAGGGTGCCTTCACCCATGTCGCGACCTAT
CAGGCCGACCTCGTCGTCGCCGACGTCCTCGGCCGTCCGACGCCCGAGGCGGAGTACCGCGCGCTGCCTCGGGTGACGTT
CACCGACCCCGAGGTCGGGTCGGTCGGCCTGAGCGAGGCACAGGCCCGCGAGCAGGGCCTGGCGGTCGCGGTCGGCACCG
CGAACCTGCAGCACACCGCCCGGGGCTGGCTGCACAAGGCCGGCAGCCACGGCCTGATCAAGCTGGTCATGGACACCGAC
ACCGGGCTGTTGGTCGGCGCCACGTCCGCGGGTCCGGTCGGCGGCGAGGTGCTCGGCGCCCTGGCGGTCGCCATCCACGG
CCGGGTGCCGGTCGAGCAGCTGCGCCACATGATCTGGGCCTACCCGACCTTCCACCGCGGGATCCAGGACGCCCTGCGCG
ACCTGCCGATCGGGTGA

Upstream 100 bases:

>100_bases
GGTACTACCCCTCGCCGTCGCCGGCAGCTGAGGAGATCGGCGGGCGCGTCGCCTTCTGGCAGGGCGTCCGGGTCGTCGAG
GCGCCGGCCGAGGCAGCACG

Downstream 100 bases:

>100_bases
GGGCACCAGCCGGCGCCGGCTCAGGATCAACCCGGCGACTCGGCCACGGCTCGCACCTCGGAGAACGGCGTAGGCGACCG
CCCGGCCCGAGTCGAGCAGC

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTGPTTRADIVVVGMGVGGEAVAGSLAEAGLDVVGIEAELVGGECPYWGCIPSKMMIRAANLIAEASRIPGMSGTVDVRP
DWTPVADRIRHEATDDWNDQVAVDRFTGKGGRFVRGAATVLGPRSVSVEGVGVIEARRGIVLATGTSSVAPPIDGLADTP
FWTNREAVSAKDLPASLVVLGGGAIGVEIGQAFARFEVEVTVVEAAERILPAEEPEVSALLADTFRSEGITVLAGRAATQ
VGYAGGTFAIRLDNGDDVTAEGLLVATGRRPQVAPEMLRALELEPGLRALPVDERMRVADGVWAVGDVTGKGAFTHVATY
QADLVVADVLGRPTPEAEYRALPRVTFTDPEVGSVGLSEAQAREQGLAVAVGTANLQHTARGWLHKAGSHGLIKLVMDTD
TGLLVGATSAGPVGGEVLGALAVAIHGRVPVEQLRHMIWAYPTFHRGIQDALRDLPIG

Sequences:

>Translated_458_residues
MTGPTTRADIVVVGMGVGGEAVAGSLAEAGLDVVGIEAELVGGECPYWGCIPSKMMIRAANLIAEASRIPGMSGTVDVRP
DWTPVADRIRHEATDDWNDQVAVDRFTGKGGRFVRGAATVLGPRSVSVEGVGVIEARRGIVLATGTSSVAPPIDGLADTP
FWTNREAVSAKDLPASLVVLGGGAIGVEIGQAFARFEVEVTVVEAAERILPAEEPEVSALLADTFRSEGITVLAGRAATQ
VGYAGGTFAIRLDNGDDVTAEGLLVATGRRPQVAPEMLRALELEPGLRALPVDERMRVADGVWAVGDVTGKGAFTHVATY
QADLVVADVLGRPTPEAEYRALPRVTFTDPEVGSVGLSEAQAREQGLAVAVGTANLQHTARGWLHKAGSHGLIKLVMDTD
TGLLVGATSAGPVGGEVLGALAVAIHGRVPVEQLRHMIWAYPTFHRGIQDALRDLPIG
>Mature_457_residues
TGPTTRADIVVVGMGVGGEAVAGSLAEAGLDVVGIEAELVGGECPYWGCIPSKMMIRAANLIAEASRIPGMSGTVDVRPD
WTPVADRIRHEATDDWNDQVAVDRFTGKGGRFVRGAATVLGPRSVSVEGVGVIEARRGIVLATGTSSVAPPIDGLADTPF
WTNREAVSAKDLPASLVVLGGGAIGVEIGQAFARFEVEVTVVEAAERILPAEEPEVSALLADTFRSEGITVLAGRAATQV
GYAGGTFAIRLDNGDDVTAEGLLVATGRRPQVAPEMLRALELEPGLRALPVDERMRVADGVWAVGDVTGKGAFTHVATYQ
ADLVVADVLGRPTPEAEYRALPRVTFTDPEVGSVGLSEAQAREQGLAVAVGTANLQHTARGWLHKAGSHGLIKLVMDTDT
GLLVGATSAGPVGGEVLGALAVAIHGRVPVEQLRHMIWAYPTFHRGIQDALRDLPIG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=27.3118279569892, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22035672, Length=441, Percent_Identity=25.8503401360544, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI50301238, Length=441, Percent_Identity=22.9024943310658, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=27.9017857142857, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786307, Length=483, Percent_Identity=26.2939958592132, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI87082354, Length=450, Percent_Identity=25.5555555555556, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789915, Length=345, Percent_Identity=26.3768115942029, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=26.5086206896552, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=357, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71983429, Length=357, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=24.6808510638298, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325240, Length=392, Percent_Identity=23.9795918367347, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=26.2820512820513, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640549, Length=465, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640553, Length=465, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640551, Length=465, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=26.1146496815287, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 47650; Mature: 47519

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPTTRADIVVVGMGVGGEAVAGSLAEAGLDVVGIEAELVGGECPYWGCIPSKMMIRAA
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHH
NLIAEASRIPGMSGTVDVRPDWTPVADRIRHEATDDWNDQVAVDRFTGKGGRFVRGAATV
HHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECCEEE
LGPRSVSVEGVGVIEARRGIVLATGTSSVAPPIDGLADTPFWTNREAVSAKDLPASLVVL
ECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GGGAIGVEIGQAFARFEVEVTVVEAAERILPAEEPEVSALLADTFRSEGITVLAGRAATQ
ECCEEEHHHHHHEEEEEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCHHC
VGYAGGTFAIRLDNGDDVTAEGLLVATGRRPQVAPEMLRALELEPGLRALPVDERMRVAD
CCCCCCEEEEEECCCCCCEECCEEEECCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHC
GVWAVGDVTGKGAFTHVATYQADLVVADVLGRPTPEAEYRALPRVTFTDPEVGSVGLSEA
CEEEEECCCCCCCEEEEEEEHHHEEEEHHHCCCCCCHHHHCCCEEEECCCCCCCCCCHHH
QAREQGLAVAVGTANLQHTARGWLHKAGSHGLIKLVMDTDTGLLVGATSAGPVGGEVLGA
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHH
LAVAIHGRVPVEQLRHMIWAYPTFHRGIQDALRDLPIG
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGPTTRADIVVVGMGVGGEAVAGSLAEAGLDVVGIEAELVGGECPYWGCIPSKMMIRAA
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHH
NLIAEASRIPGMSGTVDVRPDWTPVADRIRHEATDDWNDQVAVDRFTGKGGRFVRGAATV
HHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECCEEE
LGPRSVSVEGVGVIEARRGIVLATGTSSVAPPIDGLADTPFWTNREAVSAKDLPASLVVL
ECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GGGAIGVEIGQAFARFEVEVTVVEAAERILPAEEPEVSALLADTFRSEGITVLAGRAATQ
ECCEEEHHHHHHEEEEEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCHHC
VGYAGGTFAIRLDNGDDVTAEGLLVATGRRPQVAPEMLRALELEPGLRALPVDERMRVAD
CCCCCCEEEEEECCCCCCEECCEEEECCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHC
GVWAVGDVTGKGAFTHVATYQADLVVADVLGRPTPEAEYRALPRVTFTDPEVGSVGLSEA
CEEEEECCCCCCCEEEEEEEHHHEEEEHHHCCCCCCHHHHCCCEEEECCCCCCCCCCHHH
QAREQGLAVAVGTANLQHTARGWLHKAGSHGLIKLVMDTDTGLLVGATSAGPVGGEVLGA
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHH
LAVAIHGRVPVEQLRHMIWAYPTFHRGIQDALRDLPIG
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2691338; 2265748 [H]