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The map label for this gene is mprB [H]

Identifier: 119716294

GI number: 119716294

Start: 2206622

End: 2208067

Strand: Direct

Name: mprB [H]

Synonym: Noca_2063

Alternate gene names: 119716294

Gene position: 2206622-2208067 (Clockwise)

Preceding gene: 119716293

Following gene: 119716295

Centisome position: 44.26

GC content: 75.45

Gene sequence:

>1446_bases
ATGACGTCGCTGCGGGGCCGGGTGTCCCGGCTGCCGCTGCGGATCCGCCTGGTCGCGGGCTTCTCCGCGGCCATGTTCGT
CGTGCTCCTCGCCGCCGGCACCTTCGTCTACTGGCGGGTGGGCTACGCCCTGGACCGCGGCCTGGACACCGAGCTCGCGC
AGGCCACCCGCTCCCTGACCCCGCTGGTCGGGGCCGACGGCCGGGTGACCGACCGGTCCGCCGCGGACGCCACCGGCGTC
GCCTGGCAGGTGCTGGAGTCCAAGGGCACCATCTTGGACCGTGGGGGCGTCCGGGCGCCCACGGGCATGGTCGGAGCCCA
CCAACTCGAGCGGATCGCCGGGAGTCACCGGACCTTCAACGTCGGCGACTTCCTGCCGGTCTCCGACGACCCCTACCGGC
TCCGCGTCACCCGGCTCGACGACGGCAGCGGCCACTACCTGCTGGTCGCCGTCCGCCGTGACCACCGCGACGAGGCGCTG
CGCGAGCTTCTGGCCCAGCTGGTCCTCGCGGGCCTCGGTGCGCTCGTGGTGACCGCGTTCGTGGGGGAGCGGCTCGCGCG
CGCCGCCCTGCGCCCCGTGGAGCGCTACCGCCGCCGGGCCGCCGCGATCGCCGCGGGCGCCCTCGACCTGCGCCTCGACG
TGTCGGTCTCCCGTGACGACGAGGTCACCCGGCTGGGGCACACCCTCAACGACATGCTGACCTCCCTGGAGCGGGCGCTG
GACCGGGAGCGCCAGTTCGTCAACGAGGCCAGCCACGAGCTGCGCACCCCGATCACGCTGCTCACCAGCCGGGTCCAGCT
CGCCCGCCGCCGACCGCGCACCCAGCAGGAGCACGAACGGGTCCTCGAGGAGCTCCAGGTCGACCTGGACCGGCTGGCCC
GGCTCGCGGAGCAGCTGCTCGAGCTCGGGGGTGCCACCGGCCGGAGCGGTCACGAGACGTGCGACCTGGCGGCGGTCACC
GCCCGCGTGGTCAACCAGCGCCGGCTCGCCGCGCCGGGCGAGGCGGCCCACACCTCGACCGAGATCCCCGGTGAGCCGGT
GCCGGTCGCGGTGGCCGACTTCGAGGTCGAGCGGATGCTGACCAACCTCCTCGACAACGCGGCCCTCCACGGGGCCGCGC
CGTACGTCGTCACCGTCGACCGGCCGGACCCGCGCTGGGGGCGGCTGCTGGTCGCCGACGCCGGTCCGGGACTCGCGCCC
GAGATCCTCGACACGGCGACCCGGCGGTTCGTCCGGTCCGAGGAGGCGCGCAGCCGTCCCGGCTCGGGTCTCGGCCTGGC
GCTGGTCCAGGCGATGGTCGCCCAGGCGGGCGGCGAGCTGCGGCTGTGCCATGGCGGCCACCACGCCTCGCACGGTGGCG
GCCGCGCACCGGTCGCCTGCACCCACGGCCCCGAGATGACCGTCAGCATCCTGCTCCCGACCGAGGCCGCCGCGAACACC
GAGTGA

Upstream 100 bases:

>100_bases
TCGCCGCGATCCGGGCCAAGATCGACAAGCCGTTCGGTACCGAGACCATCACGACGCTGCGCGGCGTCGGCTACCGCGTC
GACCCGACCCCGGCGGTGCG

Downstream 100 bases:

>100_bases
GCTGCGGCTTCACCTCCACTTCATGTTCCGGGGCCTAGGTTCCCGCCGTGCCCGAGGAGACGACCAGCGTGCAGGAGCCG
GCCGCACCGCCGACCGGGCC

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTSLRGRVSRLPLRIRLVAGFSAAMFVVLLAAGTFVYWRVGYALDRGLDTELAQATRSLTPLVGADGRVTDRSAADATGV
AWQVLESKGTILDRGGVRAPTGMVGAHQLERIAGSHRTFNVGDFLPVSDDPYRLRVTRLDDGSGHYLLVAVRRDHRDEAL
RELLAQLVLAGLGALVVTAFVGERLARAALRPVERYRRRAAAIAAGALDLRLDVSVSRDDEVTRLGHTLNDMLTSLERAL
DRERQFVNEASHELRTPITLLTSRVQLARRRPRTQQEHERVLEELQVDLDRLARLAEQLLELGGATGRSGHETCDLAAVT
ARVVNQRRLAAPGEAAHTSTEIPGEPVPVAVADFEVERMLTNLLDNAALHGAAPYVVTVDRPDPRWGRLLVADAGPGLAP
EILDTATRRFVRSEEARSRPGSGLGLALVQAMVAQAGGELRLCHGGHHASHGGGRAPVACTHGPEMTVSILLPTEAAANT
E

Sequences:

>Translated_481_residues
MTSLRGRVSRLPLRIRLVAGFSAAMFVVLLAAGTFVYWRVGYALDRGLDTELAQATRSLTPLVGADGRVTDRSAADATGV
AWQVLESKGTILDRGGVRAPTGMVGAHQLERIAGSHRTFNVGDFLPVSDDPYRLRVTRLDDGSGHYLLVAVRRDHRDEAL
RELLAQLVLAGLGALVVTAFVGERLARAALRPVERYRRRAAAIAAGALDLRLDVSVSRDDEVTRLGHTLNDMLTSLERAL
DRERQFVNEASHELRTPITLLTSRVQLARRRPRTQQEHERVLEELQVDLDRLARLAEQLLELGGATGRSGHETCDLAAVT
ARVVNQRRLAAPGEAAHTSTEIPGEPVPVAVADFEVERMLTNLLDNAALHGAAPYVVTVDRPDPRWGRLLVADAGPGLAP
EILDTATRRFVRSEEARSRPGSGLGLALVQAMVAQAGGELRLCHGGHHASHGGGRAPVACTHGPEMTVSILLPTEAAANT
E
>Mature_480_residues
TSLRGRVSRLPLRIRLVAGFSAAMFVVLLAAGTFVYWRVGYALDRGLDTELAQATRSLTPLVGADGRVTDRSAADATGVA
WQVLESKGTILDRGGVRAPTGMVGAHQLERIAGSHRTFNVGDFLPVSDDPYRLRVTRLDDGSGHYLLVAVRRDHRDEALR
ELLAQLVLAGLGALVVTAFVGERLARAALRPVERYRRRAAAIAAGALDLRLDVSVSRDDEVTRLGHTLNDMLTSLERALD
RERQFVNEASHELRTPITLLTSRVQLARRRPRTQQEHERVLEELQVDLDRLARLAEQLLELGGATGRSGHETCDLAAVTA
RVVNQRRLAAPGEAAHTSTEIPGEPVPVAVADFEVERMLTNLLDNAALHGAAPYVVTVDRPDPRWGRLLVADAGPGLAPE
ILDTATRRFVRSEEARSRPGSGLGLALVQAMVAQAGGELRLCHGGHHASHGGGRAPVACTHGPEMTVSILLPTEAAANTE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=317, Percent_Identity=27.1293375394322, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=319, Percent_Identity=26.6457680250784, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=288, Percent_Identity=27.4305555555556, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789808, Length=223, Percent_Identity=27.8026905829596, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=481, Percent_Identity=24.7401247401247, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=25.830258302583, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=275, Percent_Identity=26.1818181818182, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786912, Length=193, Percent_Identity=27.979274611399, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51941; Mature: 51810

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLRGRVSRLPLRIRLVAGFSAAMFVVLLAAGTFVYWRVGYALDRGLDTELAQATRSLT
CCCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PLVGADGRVTDRSAADATGVAWQVLESKGTILDRGGVRAPTGMVGAHQLERIAGSHRTFN
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEC
VGDFLPVSDDPYRLRVTRLDDGSGHYLLVAVRRDHRDEALRELLAQLVLAGLGALVVTAF
CCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGERLARAALRPVERYRRRAAAIAAGALDLRLDVSVSRDDEVTRLGHTLNDMLTSLERAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
DRERQFVNEASHELRTPITLLTSRVQLARRRPRTQQEHERVLEELQVDLDRLARLAEQLL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGGATGRSGHETCDLAAVTARVVNQRRLAAPGEAAHTSTEIPGEPVPVAVADFEVERML
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHH
TNLLDNAALHGAAPYVVTVDRPDPRWGRLLVADAGPGLAPEILDTATRRFVRSEEARSRP
HHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
GSGLGLALVQAMVAQAGGELRLCHGGHHASHGGGRAPVACTHGPEMTVSILLPTEAAANT
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCC
E
C
>Mature Secondary Structure 
TSLRGRVSRLPLRIRLVAGFSAAMFVVLLAAGTFVYWRVGYALDRGLDTELAQATRSLT
CCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PLVGADGRVTDRSAADATGVAWQVLESKGTILDRGGVRAPTGMVGAHQLERIAGSHRTFN
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEC
VGDFLPVSDDPYRLRVTRLDDGSGHYLLVAVRRDHRDEALRELLAQLVLAGLGALVVTAF
CCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGERLARAALRPVERYRRRAAAIAAGALDLRLDVSVSRDDEVTRLGHTLNDMLTSLERAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
DRERQFVNEASHELRTPITLLTSRVQLARRRPRTQQEHERVLEELQVDLDRLARLAEQLL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGGATGRSGHETCDLAAVTARVVNQRRLAAPGEAAHTSTEIPGEPVPVAVADFEVERML
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHH
TNLLDNAALHGAAPYVVTVDRPDPRWGRLLVADAGPGLAPEILDTATRRFVRSEEARSRP
HHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
GSGLGLALVQAMVAQAGGELRLCHGGHHASHGGGRAPVACTHGPEMTVSILLPTEAAANT
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA