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The map label for this gene is tcrA [H]

Identifier: 119716293

GI number: 119716293

Start: 2205939

End: 2206625

Strand: Direct

Name: tcrA [H]

Synonym: Noca_2062

Alternate gene names: 119716293

Gene position: 2205939-2206625 (Clockwise)

Preceding gene: 119716292

Following gene: 119716294

Centisome position: 44.24

GC content: 73.07

Gene sequence:

>687_bases
GTGAGGATCCTGGTGGCCGAGGACGACGTCCGCCTCGCCGACGTCCTCGAGGAGTCCCTGGCCGAGGCCGGGTGGCAGGT
CGAGGTGGCGCACGACGGCCGCTCGGCGTACGAGCGGCTGCTCTCCGACTCCAGCCTGGACGTGGCGCTGCTCGACTGGA
TGCTGCCGGGCCTGGACGGGGTGACCGTGGCCCGGCGGCTGCGCGACCTGGGCGTCGCGCTGCCGATCCTGATGCTCACG
GCCCGTGGTGACGTCCGCGACCGGGTCAGCGGCCTGGACGCCGGCGCCGACGACTACCTGCCCAAGCCGTTCGACCTCGA
CGAGCTGCTGGCCCGGCTGCGCGCGCTCTACCGCCGCGGCAGCCTGGTGGGCGAGGCGCCCGTGCAGCTCGGCGACCTGG
TCGTGGACCCGGTCGCCCGCCGGGTCACCCGCGGCGGCGTCGAGATCGTGCTGTCCGCGCGCGAGTTCGACATCTTGCAC
CTCCTGGTCTCGCACGCGGGGCGCGTGGTGAGCCGGCTGATGATCCTCGACGAGGTGTGGGACGGCGAGACCGACCTGCG
CAGCAACGTGATCGACGTGCACCTCGCCGCGATCCGGGCCAAGATCGACAAGCCGTTCGGTACCGAGACCATCACGACGC
TGCGCGGCGTCGGCTACCGCGTCGACCCGACCCCGGCGGTGCGATGA

Upstream 100 bases:

>100_bases
TGGACGCGCGGGCCGCGGAGGGGTACTTGGTACACCACTACGGTGAACAGCGGACGTACGGCGACTGGCACGTCTGGGAG
CGAGAGGAAGGAGTGGGCCC

Downstream 100 bases:

>100_bases
CGTCGCTGCGGGGCCGGGTGTCCCGGCTGCCGCTGCGGATCCGCCTGGTCGCGGGCTTCTCCGCGGCCATGTTCGTCGTG
CTCCTCGCCGCCGGCACCTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRILVAEDDVRLADVLEESLAEAGWQVEVAHDGRSAYERLLSDSSLDVALLDWMLPGLDGVTVARRLRDLGVALPILMLT
ARGDVRDRVSGLDAGADDYLPKPFDLDELLARLRALYRRGSLVGEAPVQLGDLVVDPVARRVTRGGVEIVLSAREFDILH
LLVSHAGRVVSRLMILDEVWDGETDLRSNVIDVHLAAIRAKIDKPFGTETITTLRGVGYRVDPTPAVR

Sequences:

>Translated_228_residues
MRILVAEDDVRLADVLEESLAEAGWQVEVAHDGRSAYERLLSDSSLDVALLDWMLPGLDGVTVARRLRDLGVALPILMLT
ARGDVRDRVSGLDAGADDYLPKPFDLDELLARLRALYRRGSLVGEAPVQLGDLVVDPVARRVTRGGVEIVLSAREFDILH
LLVSHAGRVVSRLMILDEVWDGETDLRSNVIDVHLAAIRAKIDKPFGTETITTLRGVGYRVDPTPAVR
>Mature_228_residues
MRILVAEDDVRLADVLEESLAEAGWQVEVAHDGRSAYERLLSDSSLDVALLDWMLPGLDGVTVARRLRDLGVALPILMLT
ARGDVRDRVSGLDAGADDYLPKPFDLDELLARLRALYRRGSLVGEAPVQLGDLVVDPVARRVTRGGVEIVLSAREFDILH
LLVSHAGRVVSRLMILDEVWDGETDLRSNVIDVHLAAIRAKIDKPFGTETITTLRGVGYRVDPTPAVR

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=42.6008968609865, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=41.1764705882353, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=39.2694063926941, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.7713004484305, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=38.3561643835616, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=38.0530973451327, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.5296803652968, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=34.5132743362832, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=31.981981981982, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.3842794759825, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=36.1111111111111, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790299, Length=109, Percent_Identity=38.5321100917431, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=107, Percent_Identity=34.5794392523364, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25047; Mature: 25047

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVAEDDVRLADVLEESLAEAGWQVEVAHDGRSAYERLLSDSSLDVALLDWMLPGLDG
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCH
VTVARRLRDLGVALPILMLTARGDVRDRVSGLDAGADDYLPKPFDLDELLARLRALYRRG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
SLVGEAPVQLGDLVVDPVARRVTRGGVEIVLSAREFDILHLLVSHAGRVVSRLMILDEVW
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGETDLRSNVIDVHLAAIRAKIDKPFGTETITTLRGVGYRVDPTPAVR
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MRILVAEDDVRLADVLEESLAEAGWQVEVAHDGRSAYERLLSDSSLDVALLDWMLPGLDG
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCH
VTVARRLRDLGVALPILMLTARGDVRDRVSGLDAGADDYLPKPFDLDELLARLRALYRRG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
SLVGEAPVQLGDLVVDPVARRVTRGGVEIVLSAREFDILHLLVSHAGRVVSRLMILDEVW
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGETDLRSNVIDVHLAAIRAKIDKPFGTETITTLRGVGYRVDPTPAVR
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]