BacMap

Definition	Nocardioides sp. JS614 chromosome, complete genome.
Accession	NC_008699
Length	4,985,871

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The map label for this gene is pknB [H]

Identifier: 119716237

GI number: 119716237

Start: 2147198

End: 2148049

Strand: Direct

Name: pknB [H]

Synonym: Noca_2005

Alternate gene names: 119716237

Gene position: 2147198-2148049 (Clockwise)

Preceding gene: 119716233

Following gene: 119716241

Centisome position: 43.07

GC content: 74.77

Gene sequence:

>852_bases
GTGCCGAACCCGTCCTCCTGGGGCTTCGCCGAGGGTGACGCGATCACCGCCGAGCTGACGGCCGTCCGTCGGCTCGGCGG
TGGGTCGGCCTACGAGGCCTACCTGGCCTTCGACGAGCTGACCTACCTCCCGGTGGTCGTGAAGCTGGTGCGTCCCGACC
TGGTCCGCGACGAGCACGCCCTGCGCGGGCTGACCCGCGAGGTCGAGGCGCTCGCGACGGTCAACCACCCGGTCGTGGTG
CGCGGCCTGCGGCACGAGCCGGGTGGGCCGCGCCCCCACGTCGTGCTCGAGCAGGTCGACGGCCCGCGGCTCTCGACGCT
GCTGCGCCGCTACGGCCCGCTCCAGGAGCAGCAGTACCTCCCGCTCGCGATCGAGGTCGCCAGTGCGCTGCACTACCTGC
GCCACCTGGGCTGGGTGCACCTCGACGTCAAGCCCAGCAACGTGATCATGGGCGCCCCCGCGCGGCTGATCGACCTCTCG
GTCGCCCGGCCGGTGGCCGACGCCGCCGACACGCGGCAGGTCGGCACCGACGCCTACATGGCGCCCGAGCAGGCCGACCC
CGAGCGGTACGGCGCGCCCGGGCCGGCCAGCGACGTGTGGGGGCTGTGCGCCACCTTGTTCGAGGCGGTCGCCGGCTACC
GCGCCTTCGACGGCCACGGCTTCCCCCAGCTCGACGAGGACCCGTACGAGCTGCCCGACCGGACGCCGACCGAGGTGGTC
AAGGTCCTGTACGCCGGCCTCGACCGCGCCGCCGCCAACCGCCCGCTGCCCCACGAGCTGGCCGAGGCGCTCGAACCGGT
CCTCGACCGGCTCCCGGCCGCGCGGCTGGCCGGAGCCTTCAAGGCCTCCTGA

Upstream 100 bases:

>100_bases
GTGCGCGACCTGACCAGCGACGGTCCGGGCAGCGGCAACGTGGACCACTCGCGGCACCACACCAACGACGGCACCCGCCA
CAACACCCGGGGCTGACGTC

Downstream 100 bases:

>100_bases
GGCCGAGTCAGCGGTTGAAGCGGTACCCCATGCCCCGGACGGTGGCGATGGTGTCGGCGCCGAGCTTCTTGCGCAGATAG
CCGACGTACACGTCGACCAC

Product: protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHALRGLTREVEALATVNHPVVV
RGLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYLPLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLS
VARPVADAADTRQVGTDAYMAPEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVV
KVLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS

Sequences:

>Translated_283_residues
MPNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHALRGLTREVEALATVNHPVVV
RGLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYLPLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLS
VARPVADAADTRQVGTDAYMAPEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVV
KVLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS
>Mature_282_residues
PNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHALRGLTREVEALATVNHPVVVR
GLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYLPLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLSV
ARPVADAADTRQVGTDAYMAPEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVVK
VLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS

Specific function: Unknown

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI33636756, Length=230, Percent_Identity=26.5217391304348, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22035600, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI217330634, Length=222, Percent_Identity=28.8288288288288, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI254028237, Length=234, Percent_Identity=26.0683760683761, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI254028240, Length=234, Percent_Identity=26.0683760683761, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI254028232, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI86990441, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19424132, Length=215, Percent_Identity=26.9767441860465, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI5579478, Length=207, Percent_Identity=27.0531400966184, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI254028234, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI46877068, Length=203, Percent_Identity=26.1083743842365, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI6005850, Length=217, Percent_Identity=24.8847926267281, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI193083127, Length=230, Percent_Identity=25.6521739130435, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI193083125, Length=230, Percent_Identity=25.6521739130435, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI54112407, Length=217, Percent_Identity=24.8847926267281, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI46852166, Length=230, Percent_Identity=25.6521739130435, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI193083129, Length=230, Percent_Identity=25.6521739130435, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI261244927, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI261244923, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI19923407, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI261244925, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI261244921, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI94557301, Length=203, Percent_Identity=26.6009852216749, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7662170, Length=217, Percent_Identity=23.963133640553, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI261244929, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI222418622, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI15011880, Length=198, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI153791472, Length=208, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150456432, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21361358, Length=198, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI13569922, Length=178, Percent_Identity=25.8426966292135, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI110349738, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20070158, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62865639, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62865641, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62865643, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI45827809, Length=209, Percent_Identity=29.6650717703349, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI25168261, Length=171, Percent_Identity=32.1637426900585, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI282847398, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI20127541, Length=171, Percent_Identity=32.1637426900585, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI209364619, Length=206, Percent_Identity=27.6699029126214, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI109633026, Length=183, Percent_Identity=27.3224043715847, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193204599, Length=231, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17566666, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993310, Length=248, Percent_Identity=24.5967741935484, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993315, Length=214, Percent_Identity=24.7663551401869, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193208795, Length=161, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193208793, Length=161, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17511015, Length=219, Percent_Identity=24.2009132420091, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995452, Length=203, Percent_Identity=23.6453201970443, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI32563802, Length=210, Percent_Identity=29.0476190476191, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25152839, Length=203, Percent_Identity=23.6453201970443, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25152842, Length=203, Percent_Identity=23.6453201970443, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25151367, Length=204, Percent_Identity=25.4901960784314, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71990759, Length=204, Percent_Identity=25.4901960784314, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533246, Length=244, Percent_Identity=24.5901639344262, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25153836, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321259, Length=241, Percent_Identity=25.3112033195021, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325104, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6325047, Length=155, Percent_Identity=26.4516129032258, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550904, Length=244, Percent_Identity=29.9180327868852, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550091, Length=244, Percent_Identity=29.9180327868852, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553923, Length=203, Percent_Identity=23.6453201970443, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639066, Length=203, Percent_Identity=23.6453201970443, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137472, Length=203, Percent_Identity=23.6453201970443, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281361563, Length=206, Percent_Identity=28.1553398058252, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356423, Length=206, Percent_Identity=28.1553398058252, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281361348, Length=241, Percent_Identity=29.045643153527, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137538, Length=241, Percent_Identity=29.045643153527, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647605, Length=198, Percent_Identity=26.7676767676768, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737298, Length=156, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281360507, Length=202, Percent_Identity=28.2178217821782, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45552175, Length=202, Percent_Identity=28.2178217821782, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI161077232, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077230, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24655167, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR005543
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR002290 [H]

Pfam domain/function: PF03793 PASTA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 30749; Mature: 30618

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LRGLTREVEALATVNHPVVVRGLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYL
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCC
PLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLSVARPVADAADTRQVGTDAYM
HHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCC
APEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVV
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KVLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
PNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LRGLTREVEALATVNHPVVVRGLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYL
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCC
PLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLSVARPVADAADTRQVGTDAYM
HHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCC
APEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVV
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KVLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969512; 11234002 [H]