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The map label for this gene is gutB [H]

Identifier: 119716231

GI number: 119716231

Start: 2140340

End: 2141527

Strand: Direct

Name: gutB [H]

Synonym: Noca_1999

Alternate gene names: 119716231

Gene position: 2140340-2141527 (Clockwise)

Preceding gene: 119716230

Following gene: 119716232

Centisome position: 42.93

GC content: 75.76

Gene sequence:

>1188_bases
ATGCTCGCGCTGGAGATGTTCCGGTCGGTCTCGCGGACCATGGCCGGCAAGGCGATCGGCGGCCGGATGCCCGGCGTGCT
GTCCGGCTTCGCCGCGCCGCTGCGGCTGGTCACCATCGACGAGCCGCGGGTCGAGCGGCCCGGCTGGGCGCGGCTGCGCA
CCCGGCTCTCCGGCATCTGCGGCTCCGACCTGGGCGCGCTCTCGGGCCGCACCAGCCTGTACTTCTCCGCGGTCGTGTCG
CTGCCGTTCGTGCCCGGGCACGAGGTGGTCGCCGAGCTGCTGGACGACTGCGAGGACCTGCCGGCCGGCACCCGCGTCGT
GGTCGACCCCGTGCTGGGCTGCGCCGCGCGGGGTGTCGAGCCGTGCGAGGCGTGCGCGGCCGGCGCGACCAACCGGTGCG
CCCGGATCACCGTCGGGCACCTCTCACCCGGCCTGCAGACCGGGTTCTGCCACGACACCGGCGGCGGCTGGGGCCAGCAG
CTGGCCGCCCACCGCAGCCAGCTCCACCCGGTCCCGGAGGGCTTCTCCGACGAGCAGGCGATCCTGATCGAGCCGGTGGC
CTGCGCCGTGCACACGGCGCTGCGCGCCGGGGTCGCCGCCGGCGACCGGGTGCTGGTCAGCGGGGCCGGGTCGGTCGGGC
TGTTCGCCACGCTCGCGCTGCGCGAGCTCACCGAGGCGGGCGAGATCATCGTGGTCGCCAAGCACCCCCACCAGCGCGAG
CTGGCCCGCGAGCTGGGCGCGACCGAGGTCGTCGCGCCGGGCGAGGTGCTGCGGCGGGTACGCCGCTCCACGGGCGCCTT
CCAGCTCGAGCCGGAGTTCTCCACGCCGTACCTCCTCGGCGGCGTCGACGTCGCCGTCGACGCGGTCGGGAGCAAGCAGT
CGCTGGAGAGTGCCCTCCAGGCCACCCGGGCCGGGGGCCGGGTGGTGCTGTCCGGCATGCCCGCCGCCGCCGACCTGTCC
GCCGCCTGGTTCCGCGAGCTCGAGGTGGTCGGCACCTACGCCTCGTCCCGCTCCGACGACGCGTTCGGGAGGGCGACCGA
GCTGGTCGCCACCGACGCCGTCCAGCAGCTTGCCAAGAGCGTCGCCAGCTATCCGCTGCACCGGTGGCGCGAGGCGCTCG
ACCACGCCCACTCGGCCGGCCGGCTCGGCACGGTCAAGGTGGCCTTCGACCCCCGCTCGTCCCACTGA

Upstream 100 bases:

>100_bases
GCGCGCAGGCACCGGTGGACGATCGTCGACTGGGCCAGCTCGACCTCCAGCACCCGCACCCTCAACCCGGCCGGCCCCCG
GTCATGAGGAGCCTGTCGTG

Downstream 100 bases:

>100_bases
GGAGCACACATTGAGCAGGCCAGGTTTCGTCCTCGAGGTGGACGACCGCACCCCGCCGTTGGTCGTCCACGAGGGCCTCG
GCTTCCGGCTGGAGAGCTTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLALEMFRSVSRTMAGKAIGGRMPGVLSGFAAPLRLVTIDEPRVERPGWARLRTRLSGICGSDLGALSGRTSLYFSAVVS
LPFVPGHEVVAELLDDCEDLPAGTRVVVDPVLGCAARGVEPCEACAAGATNRCARITVGHLSPGLQTGFCHDTGGGWGQQ
LAAHRSQLHPVPEGFSDEQAILIEPVACAVHTALRAGVAAGDRVLVSGAGSVGLFATLALRELTEAGEIIVVAKHPHQRE
LARELGATEVVAPGEVLRRVRRSTGAFQLEPEFSTPYLLGGVDVAVDAVGSKQSLESALQATRAGGRVVLSGMPAAADLS
AAWFRELEVVGTYASSRSDDAFGRATELVATDAVQQLAKSVASYPLHRWREALDHAHSAGRLGTVKVAFDPRSSH

Sequences:

>Translated_395_residues
MLALEMFRSVSRTMAGKAIGGRMPGVLSGFAAPLRLVTIDEPRVERPGWARLRTRLSGICGSDLGALSGRTSLYFSAVVS
LPFVPGHEVVAELLDDCEDLPAGTRVVVDPVLGCAARGVEPCEACAAGATNRCARITVGHLSPGLQTGFCHDTGGGWGQQ
LAAHRSQLHPVPEGFSDEQAILIEPVACAVHTALRAGVAAGDRVLVSGAGSVGLFATLALRELTEAGEIIVVAKHPHQRE
LARELGATEVVAPGEVLRRVRRSTGAFQLEPEFSTPYLLGGVDVAVDAVGSKQSLESALQATRAGGRVVLSGMPAAADLS
AAWFRELEVVGTYASSRSDDAFGRATELVATDAVQQLAKSVASYPLHRWREALDHAHSAGRLGTVKVAFDPRSSH
>Mature_395_residues
MLALEMFRSVSRTMAGKAIGGRMPGVLSGFAAPLRLVTIDEPRVERPGWARLRTRLSGICGSDLGALSGRTSLYFSAVVS
LPFVPGHEVVAELLDDCEDLPAGTRVVVDPVLGCAARGVEPCEACAAGATNRCARITVGHLSPGLQTGFCHDTGGGWGQQ
LAAHRSQLHPVPEGFSDEQAILIEPVACAVHTALRAGVAAGDRVLVSGAGSVGLFATLALRELTEAGEIIVVAKHPHQRE
LARELGATEVVAPGEVLRRVRRSTGAFQLEPEFSTPYLLGGVDVAVDAVGSKQSLESALQATRAGGRVVLSGMPAAADLS
AAWFRELEVVGTYASSRSDDAFGRATELVATDAVQQLAKSVASYPLHRWREALDHAHSAGRLGTVKVAFDPRSSH

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=27.0588235294118, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1790718, Length=339, Percent_Identity=27.4336283185841, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=27.190332326284, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790045, Length=291, Percent_Identity=26.8041237113402, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=331, Percent_Identity=26.8882175226586, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788073, Length=294, Percent_Identity=23.1292517006803, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788075, Length=381, Percent_Identity=24.4094488188976, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786825, Length=226, Percent_Identity=27.8761061946903, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=26.0387811634349, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=353, Percent_Identity=25.4957507082153, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=24.9283667621776, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=360, Percent_Identity=25.8333333333333, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=360, Percent_Identity=25.8333333333333, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=294, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=302, Percent_Identity=27.4834437086093, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=350, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=346, Percent_Identity=26.5895953757225, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=28.8184438040346, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137530, Length=306, Percent_Identity=30.0653594771242, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 41401; Mature: 41401

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALEMFRSVSRTMAGKAIGGRMPGVLSGFAAPLRLVTIDEPRVERPGWARLRTRLSGIC
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
GSDLGALSGRTSLYFSAVVSLPFVPGHEVVAELLDDCEDLPAGTRVVVDPVLGCAARGVE
CCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
PCEACAAGATNRCARITVGHLSPGLQTGFCHDTGGGWGQQLAAHRSQLHPVPEGFSDEQA
HHHHHHCCCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCE
ILIEPVACAVHTALRAGVAAGDRVLVSGAGSVGLFATLALRELTEAGEIIVVAKHPHQRE
EEECHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHH
LARELGATEVVAPGEVLRRVRRSTGAFQLEPEFSTPYLLGGVDVAVDAVGSKQSLESALQ
HHHHCCCCCEECCHHHHHHHHHHCCCEEECCCCCCCEEECCHHHHHHCCCCHHHHHHHHH
ATRAGGRVVLSGMPAAADLSAAWFRELEVVGTYASSRSDDAFGRATELVATDAVQQLAKS
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VASYPLHRWREALDHAHSAGRLGTVKVAFDPRSSH
HHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MLALEMFRSVSRTMAGKAIGGRMPGVLSGFAAPLRLVTIDEPRVERPGWARLRTRLSGIC
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
GSDLGALSGRTSLYFSAVVSLPFVPGHEVVAELLDDCEDLPAGTRVVVDPVLGCAARGVE
CCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
PCEACAAGATNRCARITVGHLSPGLQTGFCHDTGGGWGQQLAAHRSQLHPVPEGFSDEQA
HHHHHHCCCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCE
ILIEPVACAVHTALRAGVAAGDRVLVSGAGSVGLFATLALRELTEAGEIIVVAKHPHQRE
EEECHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHH
LARELGATEVVAPGEVLRRVRRSTGAFQLEPEFSTPYLLGGVDVAVDAVGSKQSLESALQ
HHHHCCCCCEECCHHHHHHHHHHCCCEEECCCCCCCEEECCHHHHHHCCCCHHHHHHHHH
ATRAGGRVVLSGMPAAADLSAAWFRELEVVGTYASSRSDDAFGRATELVATDAVQQLAKS
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VASYPLHRWREALDHAHSAGRLGTVKVAFDPRSSH
HHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]