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The map label for this gene is mhpC [C]

Identifier: 119716224

GI number: 119716224

Start: 2129507

End: 2130451

Strand: Direct

Name: mhpC [C]

Synonym: Noca_1992

Alternate gene names: 119716224

Gene position: 2129507-2130451 (Clockwise)

Preceding gene: 119716216

Following gene: 119716226

Centisome position: 42.71

GC content: 71.85

Gene sequence:

>945_bases
GTGGTGAGCAAGCGGTACGACGTCGAGTTCGTGACCATCCACGGCTACCGGCGCGCCTACGTGAAGGCCGGCAGCGGCCC
GGTCGTCCTGCTGCTGCACGGGCTGGGCTGCGACCACACGACGTGGGAGCCGGTCATCGAGGCGCTCAGCCGCCGCTACA
CGGTGATCGCCCCGGACCTGCTCGGCCACGGCCGGTCCGACAAGCCCCGAGCCGACTACACGCTCGGCGGCTACGCCAAC
GGCATGCGGGACCTGCTGACCGTGCTCGGCATCGACAAGGTGACCGTGATCGGGCACAGCTTCGGCGGCGGGGTCGCGAT
GCAGTTCGCCTACCAGTACCCCGAGCGCACCGAGCGGCTGATGCTGGTCGCCTCCGGAGGTCTCGGGCCCGAGGTGTCGC
CCGGCATCCGCGCGATCAGCACCCCGGGCTTCCACCAGGTGATGGGCTTGCTGACCTTGCCCGGCGTACGCCACCTCGGC
ATGGCGGGCCTGCGCACGGTGGCCAAGGGCCCGTGGAGGCTGACCCGCGACCTGGACGAGGTCGCCGACATCTACGACAC
GTTCAAGGACCCGCAGGCCCGGCACGCGATCCGGCACGTCGTGCGGGCCGTCGTCGACTGGCGCGGCCAGATCGTGACGA
TGACGGACCGGGCCTACCTCACCGAGGAGATGCCGATGTGGGTCGTCTGGGGCCGCGACGACCGGGTCATCCCGGTGCGG
CACGCGAACACCGCCGCCGCCCTGGCCCCGAATGCCCGCGTCGAGGTGATCCCGGACGCCGGCCACTTCCCGCACAAGGA
CCACCCGCACCGCTTCGCCCGGATCGTGCAGGACTTCATCCGCTCCACCGAGCCGGCCAAGTACTCCCGCGCCCGGTTCC
GCTCCCTGCTCCGCTCCGGCGGCACCGCCCCGCGCCTGCGCTCGGTCTCCTCCGACACGGCGTAG

Upstream 100 bases:

>100_bases
CGTAAAACCCCGGTAAATCAAGGCGATCCGGCTCCCGCGGCGGCGATCGGCGTGGTTGAATCGCGGCCTACGTCCACATG
GGCCCGCGTGGGGAGGCGCC

Downstream 100 bases:

>100_bases
GCGCGGCGGCGGTTTCCCCGGTTACCCGGGGAAACCGGAACTGTTGGGCCGAAGTTTCGGGCCAGAAGTTCCAACTTCCC
CGGTGAACCGGGGAAACCGC

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MVSKRYDVEFVTIHGYRRAYVKAGSGPVVLLLHGLGCDHTTWEPVIEALSRRYTVIAPDLLGHGRSDKPRADYTLGGYAN
GMRDLLTVLGIDKVTVIGHSFGGGVAMQFAYQYPERTERLMLVASGGLGPEVSPGIRAISTPGFHQVMGLLTLPGVRHLG
MAGLRTVAKGPWRLTRDLDEVADIYDTFKDPQARHAIRHVVRAVVDWRGQIVTMTDRAYLTEEMPMWVVWGRDDRVIPVR
HANTAAALAPNARVEVIPDAGHFPHKDHPHRFARIVQDFIRSTEPAKYSRARFRSLLRSGGTAPRLRSVSSDTA

Sequences:

>Translated_314_residues
MVSKRYDVEFVTIHGYRRAYVKAGSGPVVLLLHGLGCDHTTWEPVIEALSRRYTVIAPDLLGHGRSDKPRADYTLGGYAN
GMRDLLTVLGIDKVTVIGHSFGGGVAMQFAYQYPERTERLMLVASGGLGPEVSPGIRAISTPGFHQVMGLLTLPGVRHLG
MAGLRTVAKGPWRLTRDLDEVADIYDTFKDPQARHAIRHVVRAVVDWRGQIVTMTDRAYLTEEMPMWVVWGRDDRVIPVR
HANTAAALAPNARVEVIPDAGHFPHKDHPHRFARIVQDFIRSTEPAKYSRARFRSLLRSGGTAPRLRSVSSDTA
>Mature_314_residues
MVSKRYDVEFVTIHGYRRAYVKAGSGPVVLLLHGLGCDHTTWEPVIEALSRRYTVIAPDLLGHGRSDKPRADYTLGGYAN
GMRDLLTVLGIDKVTVIGHSFGGGVAMQFAYQYPERTERLMLVASGGLGPEVSPGIRAISTPGFHQVMGLLTLPGVRHLG
MAGLRTVAKGPWRLTRDLDEVADIYDTFKDPQARHAIRHVVRAVVDWRGQIVTMTDRAYLTEEMPMWVVWGRDDRVIPVR
HANTAAALAPNARVEVIPDAGHFPHKDHPHRFARIVQDFIRSTEPAKYSRARFRSLLRSGGTAPRLRSVSSDTA

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=296, Percent_Identity=25.6756756756757, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI23200012, Length=272, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI23200008, Length=272, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI218777840, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13376164, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554012, Length=305, Percent_Identity=22.6229508196721, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32566936, Length=297, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17558492, Length=297, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 34831; Mature: 34831

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKRYDVEFVTIHGYRRAYVKAGSGPVVLLLHGLGCDHTTWEPVIEALSRRYTVIAPDL
CCCCEECEEEEEEECCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEHHH
LGHGRSDKPRADYTLGGYANGMRDLLTVLGIDKVTVIGHSFGGGVAMQFAYQYPERTERL
HCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHCCCCCCEE
MLVASGGLGPEVSPGIRAISTPGFHQVMGLLTLPGVRHLGMAGLRTVAKGPWRLTRDLDE
EEEECCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VADIYDTFKDPQARHAIRHVVRAVVDWRGQIVTMTDRAYLTEEMPMWVVWGRDDRVIPVR
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEECCCCCEEEEE
HANTAAALAPNARVEVIPDAGHFPHKDHPHRFARIVQDFIRSTEPAKYSRARFRSLLRSG
CCCCHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
GTAPRLRSVSSDTA
CCCCHHHCCCCCCC
>Mature Secondary Structure
MVSKRYDVEFVTIHGYRRAYVKAGSGPVVLLLHGLGCDHTTWEPVIEALSRRYTVIAPDL
CCCCEECEEEEEEECCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEHHH
LGHGRSDKPRADYTLGGYANGMRDLLTVLGIDKVTVIGHSFGGGVAMQFAYQYPERTERL
HCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHCCCCCCEE
MLVASGGLGPEVSPGIRAISTPGFHQVMGLLTLPGVRHLGMAGLRTVAKGPWRLTRDLDE
EEEECCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VADIYDTFKDPQARHAIRHVVRAVVDWRGQIVTMTDRAYLTEEMPMWVVWGRDDRVIPVR
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEECCCCCEEEEE
HANTAAALAPNARVEVIPDAGHFPHKDHPHRFARIVQDFIRSTEPAKYSRARFRSLLRSG
CCCCHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
GTAPRLRSVSSDTA
CCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]