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The map label for this gene is fabF [H]

Identifier: 119716219

GI number: 119716219

Start: 2124328

End: 2125578

Strand: Reverse

Name: fabF [H]

Synonym: Noca_1987

Alternate gene names: 119716219

Gene position: 2125578-2124328 (Counterclockwise)

Preceding gene: 119716220

Following gene: 119716218

Centisome position: 42.63

GC content: 73.78

Gene sequence:

>1251_bases
ATGTCGAAGCGAGTCGTCGTCACCGGCCTCGGGACCACCTCCCCCGTGGGCGGTGACGTGCCCAGCACCTGGGACGCGCT
GGTCAACGGACGCTCGGGCGTCCGGTTCCTGACCGACGACTGGGCCGAGCAGATGCCGGTCAAGATCGCCGGCCGGATCG
CCGTCGAGCCCACCGAGATCCTCGAACGGGTCAAGGCGCGTCGGCTGGACCGGTCCTCGCAGTTCGCGATGGTGGCCGCC
ATGGAGGCCTGGAAGGACGCCGGTCTCGAGGGCTCGGACGTCGACCGGGACCGGCTCGGCGTCGCCATGGCCTCCGGCAT
CGGCGGCGTCACGACGCTCCTCGACAACTACGACGCGCTGCGGGAGAAGGGGCCGCGCCGGGTCTCGCCGCTCGCGGTCC
CGATGCTGATGCCCAACGCGCCGGCAGCGCAGCTGAGCCTGTACGTCGGAGCGCGCGCGGCGGTCAACACGCCGGTCTCG
GCGTGCGCCTCCGGCAACGAGGCGATCTCGTTGGCGGTCGACCAGATCCGGCTCGGCCGGGCCGACGTCGTGCTCGCGGG
CGGCACCGAGGCGGCGATCCACCCGCTGCCGATGGCGGCCTTCGCGAACATGATGGCGCTCTCGAAGACCGCCAGCGGCC
CCGACGGCGGCGACCCGACCGCCGTGTCGCGGCCGTGGGACGTCGCCCGCGACGGCTTCGTGCTCGGGGAGGGCGCCGGC
GTCCTGGTCCTCGAGTCCGAGGAGCACGCCCGCGCCCGGGGCGCCCGGATCTACGCCACGGTGCTCGGGGCCGGCATCAC
CGCGGACTCCCACGACATCGCCCAGCCCGACCCGGAGGGCCGCGGCGGCTCCCGCGCGATCCTGCGGGCGCTCGCAGAGG
CCGACATCAGCCCGGGCGACATCGCGCACGTCAACGCGCACGCCACGTCGACCCCGCAGGGCGACATCGCCGAGGGCCTG
ATGCTGCACGCGACGCTCGGCGCGCACGCGACCGACGTCGTCGTGACCAGCACCAAGTCGATGACCGGCCACCTGCTCGG
CGGCGCCGGCGCACTGGAGGCGATCGCGACCGTGCTGGCGCTCCACCACCGGGTCGCCCCGCCGACGATCAACCTGGACA
ACCAGGACCCGCAGGTCGAGCTGGACATCGCCACCAAGGCCCGCGACCTGCCGCTCGGCGACATCGCCGCGCTCAACAAC
TCCTTCGGGTTCGGCGGCGCCAACGTCGCGGTCGCGTTCGGGTCCGTCTGA

Upstream 100 bases:

>100_bases
ATCCCCGACGACGAGGTCAAGAACCTCAAGACCGTCGGCGACGCCGTCGCGTTCATCGAGCGCGCCCAGGCCTGAGGCCG
CCCGGAACTCAAGGAGCAGC

Downstream 100 bases:

>100_bases
GCCGCCCCGAAAGGACACGGACCACTGTGACTGCCACTGCCACCAAGCCGGCGAAGCTCCCCCGCGAGGAGGACCCGCGC
AACCCGGTGCACCGGCTCAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSKRVVVTGLGTTSPVGGDVPSTWDALVNGRSGVRFLTDDWAEQMPVKIAGRIAVEPTEILERVKARRLDRSSQFAMVAA
MEAWKDAGLEGSDVDRDRLGVAMASGIGGVTTLLDNYDALREKGPRRVSPLAVPMLMPNAPAAQLSLYVGARAAVNTPVS
ACASGNEAISLAVDQIRLGRADVVLAGGTEAAIHPLPMAAFANMMALSKTASGPDGGDPTAVSRPWDVARDGFVLGEGAG
VLVLESEEHARARGARIYATVLGAGITADSHDIAQPDPEGRGGSRAILRALAEADISPGDIAHVNAHATSTPQGDIAEGL
MLHATLGAHATDVVVTSTKSMTGHLLGGAGALEAIATVLALHHRVAPPTINLDNQDPQVELDIATKARDLPLGDIAALNN
SFGFGGANVAVAFGSV

Sequences:

>Translated_416_residues
MSKRVVVTGLGTTSPVGGDVPSTWDALVNGRSGVRFLTDDWAEQMPVKIAGRIAVEPTEILERVKARRLDRSSQFAMVAA
MEAWKDAGLEGSDVDRDRLGVAMASGIGGVTTLLDNYDALREKGPRRVSPLAVPMLMPNAPAAQLSLYVGARAAVNTPVS
ACASGNEAISLAVDQIRLGRADVVLAGGTEAAIHPLPMAAFANMMALSKTASGPDGGDPTAVSRPWDVARDGFVLGEGAG
VLVLESEEHARARGARIYATVLGAGITADSHDIAQPDPEGRGGSRAILRALAEADISPGDIAHVNAHATSTPQGDIAEGL
MLHATLGAHATDVVVTSTKSMTGHLLGGAGALEAIATVLALHHRVAPPTINLDNQDPQVELDIATKARDLPLGDIAALNN
SFGFGGANVAVAFGSV
>Mature_415_residues
SKRVVVTGLGTTSPVGGDVPSTWDALVNGRSGVRFLTDDWAEQMPVKIAGRIAVEPTEILERVKARRLDRSSQFAMVAAM
EAWKDAGLEGSDVDRDRLGVAMASGIGGVTTLLDNYDALREKGPRRVSPLAVPMLMPNAPAAQLSLYVGARAAVNTPVSA
CASGNEAISLAVDQIRLGRADVVLAGGTEAAIHPLPMAAFANMMALSKTASGPDGGDPTAVSRPWDVARDGFVLGEGAGV
LVLESEEHARARGARIYATVLGAGITADSHDIAQPDPEGRGGSRAILRALAEADISPGDIAHVNAHATSTPQGDIAEGLM
LHATLGAHATDVVVTSTKSMTGHLLGGAGALEAIATVLALHHRVAPPTINLDNQDPQVELDIATKARDLPLGDIAALNNS
FGFGGANVAVAFGSV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=37.4407582938389, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=44.5205479452055, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=24.0184757505774, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=43.5406698564593, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1788663, Length=409, Percent_Identity=35.2078239608802, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=34.4578313253012, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=37.9699248120301, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI212642053, Length=370, Percent_Identity=24.5945945945946, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=256, Percent_Identity=25.390625, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=34.2281879194631, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6325025, Length=274, Percent_Identity=25.5474452554745, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=38.9548693586698, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24581345, Length=264, Percent_Identity=26.5151515151515, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920632, Length=263, Percent_Identity=28.5171102661597, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221330659, Length=263, Percent_Identity=28.5171102661597, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42745; Mature: 42614

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRVVVTGLGTTSPVGGDVPSTWDALVNGRSGVRFLTDDWAEQMPVKIAGRIAVEPTEI
CCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEECHHHHHHCCEEEECEEEECHHHH
LERVKARRLDRSSQFAMVAAMEAWKDAGLEGSDVDRDRLGVAMASGIGGVTTLLDNYDAL
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCHHHCCCCHHHHHHHCHHHH
REKGPRRVSPLAVPMLMPNAPAAQLSLYVGARAAVNTPVSACASGNEAISLAVDQIRLGR
HHCCCCCCCCEEEEEECCCCCHHHEEEEECCCHHCCCCHHHHCCCCCEEEEEEEHHCCCC
ADVVLAGGTEAAIHPLPMAAFANMMALSKTASGPDGGDPTAVSRPWDVARDGFVLGEGAG
CCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VLVLESEEHARARGARIYATVLGAGITADSHDIAQPDPEGRGGSRAILRALAEADISPGD
EEEEECCHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
IAHVNAHATSTPQGDIAEGLMLHATLGAHATDVVVTSTKSMTGHLLGGAGALEAIATVLA
EEEEECCCCCCCCCHHHCCEEEEEECCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHH
LHHRVAPPTINLDNQDPQVELDIATKARDLPLGDIAALNNSFGFGGANVAVAFGSV
HHHHCCCCEECCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SKRVVVTGLGTTSPVGGDVPSTWDALVNGRSGVRFLTDDWAEQMPVKIAGRIAVEPTEI
CCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEECHHHHHHCCEEEECEEEECHHHH
LERVKARRLDRSSQFAMVAAMEAWKDAGLEGSDVDRDRLGVAMASGIGGVTTLLDNYDAL
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCHHHCCCCHHHHHHHCHHHH
REKGPRRVSPLAVPMLMPNAPAAQLSLYVGARAAVNTPVSACASGNEAISLAVDQIRLGR
HHCCCCCCCCEEEEEECCCCCHHHEEEEECCCHHCCCCHHHHCCCCCEEEEEEEHHCCCC
ADVVLAGGTEAAIHPLPMAAFANMMALSKTASGPDGGDPTAVSRPWDVARDGFVLGEGAG
CCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VLVLESEEHARARGARIYATVLGAGITADSHDIAQPDPEGRGGSRAILRALAEADISPGD
EEEEECCHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
IAHVNAHATSTPQGDIAEGLMLHATLGAHATDVVVTSTKSMTGHLLGGAGALEAIATVLA
EEEEECCCCCCCCCHHHCCEEEEEECCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHH
LHHRVAPPTINLDNQDPQVELDIATKARDLPLGDIAALNNSFGFGGANVAVAFGSV
HHHHCCCCEECCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]