Click here to switch to the map view.

The map label for this gene is accD6 [H]

Identifier: 119716218

GI number: 119716218

Start: 2122871

End: 2124301

Strand: Reverse

Name: accD6 [H]

Synonym: Noca_1986

Alternate gene names: 119716218

Gene position: 2124301-2122871 (Counterclockwise)

Preceding gene: 119716219

Following gene: 119716217

Centisome position: 42.61

GC content: 74.21

Gene sequence:

>1431_bases
GTGACTGCCACTGCCACCAAGCCGGCGAAGCTCCCCCGCGAGGAGGACCCGCGCAACCCGGTGCACCGGCTCACGGCCCT
CCTCGACGAGGGCACGCTGGAGCTGATCACCCCCGACGACGACTCGGGGATGCTCGCCGCCGTCGGCCAGGTCGACGGCA
CCCGGGTGGTGGCGTTCTGCTCGGACGCCACGGTGATGGGCGGCGCGATGGGCGACCTCGGCTGCCGCGTGGTCGTCGAC
GCCTACCACCGGGCGATGACCGACCGGATCCCGGTCATCGGCCTATGGCACTCCGGCGGCGCCCGGCTCGCCGAGGGCGT
GCTCTCCCTGCACGCGGTCGGCCGGATCTTCCAGGTGATGACCCAGGCCTCCGGACGGATCCCGCAGATCTCGGTGGTGC
TCGGTCCGGCCGCCGGCGGCGCGGCGTACGGCCCGGCCCTCACCGACGTCGTCATCCTCGGCCCCGAGGGCCGGATCTTC
GTGACCGGGCCCGACGTGGTCCGATCCGTGACCGGTGAGGACGTCGACATGCTGCGGCTCGGGGGTCCCGAGCCCCACGG
CCGGCGCTCCGGAGTGGTCCACATCCTCGCGGACACCGAGCGCGACGCACTCGACCGCGCCCGCGACGTCGCCGGGCTGC
TCGGCTCGCAGGGCTCGCTGGTCGTCGAGGACGTCGAGGACCGCGACCTGGCCGCGCTGCTCCCGGAGTCGAAGAAGCGC
GCGTACGACGTGCACCCCCTGGTCGAGTCGATCCTCGACGAGGGCACCGCCCAGGAGCTGCACGCCAGGTGGGCACCCAA
CATCGTGACCGCACTCGGCCGGCTCGGTGGCCGCACCGTCGGCGTGGTCGCGAACAACCCGCTGCGGCTGGGCGGCTGCC
TCGACTCGCTCTCCGCCGAGAAGGCCTCCCGCTTCGTGCGGATGTGCGACGCGTTCGGCGTCCCGCTCGTGGTGGTCGTC
GACGTGCCCGGCTACCTGCCCGGGGTCGGGCAGGAGTGGGACGGCGTGGTCCGCCGCGGCGCGAAGCTCCTGCACGCGTT
CGGAGAGTGCGTGGTCCCCCGGGTCACCCTGGTGACCCGCAAGACCTACGGCGGCGCGTACATCGCGATGAACGCCCGCT
CCCTGGGCGCGACGAAGGTCTTCGCGTGGCCCGGCGCAGAGGTGGCCGTGATGGGCGCGGTCGCGGCGATCCGGATCCTG
CACCGGCGCCGGCTGGCCGAGGTCGCCCCGGACATCCGTCCCCAGGTCGAGGCCGAGCTGGCGGCCGAGCACGAGCGGAT
CGCCGGCGGGGTCGACAAGGCGGTCGAGATCGGCGTGGTCGACGAGGTCGTCGAGCCGGCCGTGACCCGGAGCGCCCTCG
CCCGGGCGATCGACGACGCCGTGCAGGCCGACGGCGTCCGCCGCGGCGCCCACGGGAACATCCCGCTCTGA

Upstream 100 bases:

>100_bases
GCGACATCGCCGCGCTCAACAACTCCTTCGGGTTCGGCGGCGCCAACGTCGCGGTCGCGTTCGGGTCCGTCTGAGCCGCC
CCGAAAGGACACGGACCACT

Downstream 100 bases:

>100_bases
GCGCCCGTACGCCGGCGTAACGGCTCGGCGGCTGGTGCGTTGGACCAGGCATGACGCCCGTCACACGCCTGAGCTCCGTT
CTCGCCGCGGCCGCGCTGGC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTATATKPAKLPREEDPRNPVHRLTALLDEGTLELITPDDDSGMLAAVGQVDGTRVVAFCSDATVMGGAMGDLGCRVVVD
AYHRAMTDRIPVIGLWHSGGARLAEGVLSLHAVGRIFQVMTQASGRIPQISVVLGPAAGGAAYGPALTDVVILGPEGRIF
VTGPDVVRSVTGEDVDMLRLGGPEPHGRRSGVVHILADTERDALDRARDVAGLLGSQGSLVVEDVEDRDLAALLPESKKR
AYDVHPLVESILDEGTAQELHARWAPNIVTALGRLGGRTVGVVANNPLRLGGCLDSLSAEKASRFVRMCDAFGVPLVVVV
DVPGYLPGVGQEWDGVVRRGAKLLHAFGECVVPRVTLVTRKTYGGAYIAMNARSLGATKVFAWPGAEVAVMGAVAAIRIL
HRRRLAEVAPDIRPQVEAELAAEHERIAGGVDKAVEIGVVDEVVEPAVTRSALARAIDDAVQADGVRRGAHGNIPL

Sequences:

>Translated_476_residues
MTATATKPAKLPREEDPRNPVHRLTALLDEGTLELITPDDDSGMLAAVGQVDGTRVVAFCSDATVMGGAMGDLGCRVVVD
AYHRAMTDRIPVIGLWHSGGARLAEGVLSLHAVGRIFQVMTQASGRIPQISVVLGPAAGGAAYGPALTDVVILGPEGRIF
VTGPDVVRSVTGEDVDMLRLGGPEPHGRRSGVVHILADTERDALDRARDVAGLLGSQGSLVVEDVEDRDLAALLPESKKR
AYDVHPLVESILDEGTAQELHARWAPNIVTALGRLGGRTVGVVANNPLRLGGCLDSLSAEKASRFVRMCDAFGVPLVVVV
DVPGYLPGVGQEWDGVVRRGAKLLHAFGECVVPRVTLVTRKTYGGAYIAMNARSLGATKVFAWPGAEVAVMGAVAAIRIL
HRRRLAEVAPDIRPQVEAELAAEHERIAGGVDKAVEIGVVDEVVEPAVTRSALARAIDDAVQADGVRRGAHGNIPL
>Mature_475_residues
TATATKPAKLPREEDPRNPVHRLTALLDEGTLELITPDDDSGMLAAVGQVDGTRVVAFCSDATVMGGAMGDLGCRVVVDA
YHRAMTDRIPVIGLWHSGGARLAEGVLSLHAVGRIFQVMTQASGRIPQISVVLGPAAGGAAYGPALTDVVILGPEGRIFV
TGPDVVRSVTGEDVDMLRLGGPEPHGRRSGVVHILADTERDALDRARDVAGLLGSQGSLVVEDVEDRDLAALLPESKKRA
YDVHPLVESILDEGTAQELHARWAPNIVTALGRLGGRTVGVVANNPLRLGGCLDSLSAEKASRFVRMCDAFGVPLVVVVD
VPGYLPGVGQEWDGVVRRGAKLLHAFGECVVPRVTLVTRKTYGGAYIAMNARSLGATKVFAWPGAEVAVMGAVAAIRILH
RRRLAEVAPDIRPQVEAELAAEHERIAGGVDKAVEIGVVDEVVEPAVTRSALARAIDDAVQADGVRRGAHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=439, Percent_Identity=41.6856492027335, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI295821216, Length=426, Percent_Identity=42.018779342723, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI11545863, Length=424, Percent_Identity=30.8962264150943, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147362, Length=439, Percent_Identity=40.7744874715262, Blast_Score=319, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI25147359, Length=439, Percent_Identity=40.7744874715262, Blast_Score=319, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17552936, Length=438, Percent_Identity=30.365296803653, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=308, Percent_Identity=23.0519480519481, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586065, Length=495, Percent_Identity=28.0808080808081, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 50059; Mature: 49928

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATATKPAKLPREEDPRNPVHRLTALLDEGTLELITPDDDSGMLAAVGQVDGTRVVAFC
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCEEEEEE
SDATVMGGAMGDLGCRVVVDAYHRAMTDRIPVIGLWHSGGARLAEGVLSLHAVGRIFQVM
CCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
TQASGRIPQISVVLGPAAGGAAYGPALTDVVILGPEGRIFVTGPDVVRSVTGEDVDMLRL
HHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEECHHHHHHCCCCCCEEEEE
GGPEPHGRRSGVVHILADTERDALDRARDVAGLLGSQGSLVVEDVEDRDLAALLPESKKR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHH
AYDVHPLVESILDEGTAQELHARWAPNIVTALGRLGGRTVGVVANNPLRLGGCLDSLSAE
CEEHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCEEECHHHHHHHHH
KASRFVRMCDAFGVPLVVVVDVPGYLPGVGQEWDGVVRRGAKLLHAFGECVVPRVTLVTR
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEE
KTYGGAYIAMNARSLGATKVFAWPGAEVAVMGAVAAIRILHRRRLAEVAPDIRPQVEAEL
ECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAEHERIAGGVDKAVEIGVVDEVVEPAVTRSALARAIDDAVQADGVRRGAHGNIPL
HHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TATATKPAKLPREEDPRNPVHRLTALLDEGTLELITPDDDSGMLAAVGQVDGTRVVAFC
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCEEEEEE
SDATVMGGAMGDLGCRVVVDAYHRAMTDRIPVIGLWHSGGARLAEGVLSLHAVGRIFQVM
CCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
TQASGRIPQISVVLGPAAGGAAYGPALTDVVILGPEGRIFVTGPDVVRSVTGEDVDMLRL
HHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEECHHHHHHCCCCCCEEEEE
GGPEPHGRRSGVVHILADTERDALDRARDVAGLLGSQGSLVVEDVEDRDLAALLPESKKR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHH
AYDVHPLVESILDEGTAQELHARWAPNIVTALGRLGGRTVGVVANNPLRLGGCLDSLSAE
CEEHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCEEECHHHHHHHHH
KASRFVRMCDAFGVPLVVVVDVPGYLPGVGQEWDGVVRRGAKLLHAFGECVVPRVTLVTR
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEE
KTYGGAYIAMNARSLGATKVFAWPGAEVAVMGAVAAIRILHRRRLAEVAPDIRPQVEAEL
ECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAEHERIAGGVDKAVEIGVVDEVVEPAVTRSALARAIDDAVQADGVRRGAHGNIPL
HHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]