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The map label for this gene is phoR [H]

Identifier: 119716163

GI number: 119716163

Start: 2060803

End: 2062074

Strand: Direct

Name: phoR [H]

Synonym: Noca_1931

Alternate gene names: 119716163

Gene position: 2060803-2062074 (Clockwise)

Preceding gene: 119716162

Following gene: 119716164

Centisome position: 41.33

GC content: 73.03

Gene sequence:

>1272_bases
ATGCGTGCCTGGGGGCCACGGTGCCGGTGGGTGGTCCGGCACCTGTGCTGGAACGGCGGCGAGCCGGATCCGCGCGTCCT
TCAGTCGTCCTTCACGCTGATCCTGGCGATCGCCCTCGGGTTCCGGATCGCCGCCGAGGGGCCGGTCGCCCCGCTCTCGT
GGCCGGTGGCCGGCGTCGTCATCGCGATCGTCGGCAGCCTGATCGTGCTGACGGCGCCCGCTCCTCGGGTCGACGTCCTG
GCCCGGGCGTTGGCGGTCGTCCACATCGCTGCGCTCGGCATGCTCGCCCAGGGCTCCGAGCTCGGGATCGCCTCCGGGCT
GGTCGTGTTCCCGTCGATCTGGCTGGGCCTCGAGCTGGGGCAGCGGGGGGTAGCGCTGGCGACGGGAGCGACCGTGGCGT
TCATCGCCGTGCCGGGACTGGTCTCGCGCGGTGCCGGCGTCGCCCACGTGGAGTGGCTGCTCCTGCTGACGATCCTGGCG
GGCTTCAGCGCGTTCGCGACCGACGCCGCGCTGATCGCGGCGCGCACCGCGCAGGCCCGCGCCGAGGCTCGTGAAGCGGA
GCTCGCCGTCGCCTTGAAGGTCAAGGAGGACTTCGTCGCCCTGGTCTCGCACGAGCTGCGCACCCCGTTGACCTCGATCG
TGGGGTACGTCGCCGTCGCCTTGGAGCGCGACGACCTGGACCCGGTCCTGCGCACGCAGCTCGACGCGGTCGACCGCAAC
GGCAAGCGGCTCGAGCGGCTGGTCCAGGACCTGCTCGACGAGGTCCAGCACTCCGGTCGACCGCTGCCGCTGCGCGAGCA
GGACACCGACCTCGCCGTGATCGTCCGCGAGTGCGTCGCCGGTGCGCGCCTGCAGGCCGCCCGGGGCGGCGTCCGGCTGG
ACGCCGACGTCCCGGACAGCATCGCGTTCACCGGCGATCCCGAGCGGCTCGCCCAGGTCGTCGACAACCTGGTGTCCAAC
GCGATCAAGTACACCGAGCCGGGAGGGAGCGCCCGGGTGCAGGCGATCGTCGTCGCCGACGGCTCCGTGCGGATCTCCGT
CCAGGACACCGGCATCGGGATCGACCCCGCGGAACGGGCCCGGCTGTTCAGCCGGTTCTTCCGCGGCGCGGAGGCCAGCC
GCCGGGCGATCCAGGGCATCGGGCTCGGCCTGTCGATCACCAAGTCGATCGTGGAGAGCCACGGCGGGCGGATCGAGGTC
GACAGCGAGCCCGGCCGGGGCAGCGAGTTCCGGGTCGTGCTCCCGTCGTACGCCGCCCAACTCGCCTCCTGA

Upstream 100 bases:

>100_bases
CACCGAGTGCTCGCACCGGCCCGAACCCGGCGCCGGGCCCGGGCTCAGGTTCTGGGAGCACCCGCCGATCCTTCCCTGGA
CGAAGGACGGGAGGTGAGCG

Downstream 100 bases:

>100_bases
GGACCGTCCCCCGACTAGGCTCGCGCCGTGAGACGTGCCGTGCGCCAGCCCACGCCGCACCCGACGGGGGCGCGCCCCCC
GGCGATCCCACGAGAGCTCG

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRAWGPRCRWVVRHLCWNGGEPDPRVLQSSFTLILAIALGFRIAAEGPVAPLSWPVAGVVIAIVGSLIVLTAPAPRVDVL
ARALAVVHIAALGMLAQGSELGIASGLVVFPSIWLGLELGQRGVALATGATVAFIAVPGLVSRGAGVAHVEWLLLLTILA
GFSAFATDAALIAARTAQARAEAREAELAVALKVKEDFVALVSHELRTPLTSIVGYVAVALERDDLDPVLRTQLDAVDRN
GKRLERLVQDLLDEVQHSGRPLPLREQDTDLAVIVRECVAGARLQAARGGVRLDADVPDSIAFTGDPERLAQVVDNLVSN
AIKYTEPGGSARVQAIVVADGSVRISVQDTGIGIDPAERARLFSRFFRGAEASRRAIQGIGLGLSITKSIVESHGGRIEV
DSEPGRGSEFRVVLPSYAAQLAS

Sequences:

>Translated_423_residues
MRAWGPRCRWVVRHLCWNGGEPDPRVLQSSFTLILAIALGFRIAAEGPVAPLSWPVAGVVIAIVGSLIVLTAPAPRVDVL
ARALAVVHIAALGMLAQGSELGIASGLVVFPSIWLGLELGQRGVALATGATVAFIAVPGLVSRGAGVAHVEWLLLLTILA
GFSAFATDAALIAARTAQARAEAREAELAVALKVKEDFVALVSHELRTPLTSIVGYVAVALERDDLDPVLRTQLDAVDRN
GKRLERLVQDLLDEVQHSGRPLPLREQDTDLAVIVRECVAGARLQAARGGVRLDADVPDSIAFTGDPERLAQVVDNLVSN
AIKYTEPGGSARVQAIVVADGSVRISVQDTGIGIDPAERARLFSRFFRGAEASRRAIQGIGLGLSITKSIVESHGGRIEV
DSEPGRGSEFRVVLPSYAAQLAS
>Mature_423_residues
MRAWGPRCRWVVRHLCWNGGEPDPRVLQSSFTLILAIALGFRIAAEGPVAPLSWPVAGVVIAIVGSLIVLTAPAPRVDVL
ARALAVVHIAALGMLAQGSELGIASGLVVFPSIWLGLELGQRGVALATGATVAFIAVPGLVSRGAGVAHVEWLLLLTILA
GFSAFATDAALIAARTAQARAEAREAELAVALKVKEDFVALVSHELRTPLTSIVGYVAVALERDDLDPVLRTQLDAVDRN
GKRLERLVQDLLDEVQHSGRPLPLREQDTDLAVIVRECVAGARLQAARGGVRLDADVPDSIAFTGDPERLAQVVDNLVSN
AIKYTEPGGSARVQAIVVADGSVRISVQDTGIGIDPAERARLFSRFFRGAEASRRAIQGIGLGLSITKSIVESHGGRIEV
DSEPGRGSEFRVVLPSYAAQLAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=350, Percent_Identity=32.5714285714286, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=36.6935483870968, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=31.5315315315315, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.7354260089686, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=30.7053941908714, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=32.7433628318584, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=33.7662337662338, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=31.3432835820896, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=29.2887029288703, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=27.4193548387097, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=29.4642857142857, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=30.4029304029304, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=28.8888888888889, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=26.2443438914027, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790300, Length=230, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790861, Length=189, Percent_Identity=28.042328042328, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=153, Percent_Identity=30.718954248366, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44657; Mature: 44657

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAWGPRCRWVVRHLCWNGGEPDPRVLQSSFTLILAIALGFRIAAEGPVAPLSWPVAGVV
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHH
IAIVGSLIVLTAPAPRVDVLARALAVVHIAALGMLAQGSELGIASGLVVFPSIWLGLELG
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCC
QRGVALATGATVAFIAVPGLVSRGAGVAHVEWLLLLTILAGFSAFATDAALIAARTAQAR
CCCEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEAREAELAVALKVKEDFVALVSHELRTPLTSIVGYVAVALERDDLDPVLRTQLDAVDRN
HHHHHHHEEEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GKRLERLVQDLLDEVQHSGRPLPLREQDTDLAVIVRECVAGARLQAARGGVRLDADVPDS
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEECCCCCC
IAFTGDPERLAQVVDNLVSNAIKYTEPGGSARVQAIVVADGSVRISVQDTGIGIDPAERA
CEECCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCEEEEEEECCCCCCCHHHHH
RLFSRFFRGAEASRRAIQGIGLGLSITKSIVESHGGRIEVDSEPGRGSEFRVVLPSYAAQ
HHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCHHHHH
LAS
HCC
>Mature Secondary Structure
MRAWGPRCRWVVRHLCWNGGEPDPRVLQSSFTLILAIALGFRIAAEGPVAPLSWPVAGVV
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHH
IAIVGSLIVLTAPAPRVDVLARALAVVHIAALGMLAQGSELGIASGLVVFPSIWLGLELG
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCC
QRGVALATGATVAFIAVPGLVSRGAGVAHVEWLLLLTILAGFSAFATDAALIAARTAQAR
CCCEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEAREAELAVALKVKEDFVALVSHELRTPLTSIVGYVAVALERDDLDPVLRTQLDAVDRN
HHHHHHHEEEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GKRLERLVQDLLDEVQHSGRPLPLREQDTDLAVIVRECVAGARLQAARGGVRLDADVPDS
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEECCCCCC
IAFTGDPERLAQVVDNLVSNAIKYTEPGGSARVQAIVVADGSVRISVQDTGIGIDPAERA
CEECCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCEEEEEEECCCCCCCHHHHH
RLFSRFFRGAEASRRAIQGIGLGLSITKSIVESHGGRIEVDSEPGRGSEFRVVLPSYAAQ
HHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCHHHHH
LAS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]