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The map label for this gene is hemN [H]

Identifier: 119716130

GI number: 119716130

Start: 2028451

End: 2029731

Strand: Direct

Name: hemN [H]

Synonym: Noca_1898

Alternate gene names: 119716130

Gene position: 2028451-2029731 (Clockwise)

Preceding gene: 119716129

Following gene: 119716131

Centisome position: 40.68

GC content: 74.86

Gene sequence:

>1281_bases
GTGAGGAGTGGGTGGGAGGATGGGGTGGTGTCCCCGTCCGCGCTGCCTCCCGGTGAGCCCGCGCCCGAGGACGGGTCCCT
CCCCGCGAGCGCGCTGGCCCGGGTGGGGGAGCGCGGGTTCGGGTTCTACGTGCACGTGCCGTTCTGCACCGTGCGGTGCG
GCTACTGCGACTTCAACACCTACACCGCCGAGGAGCTGGGGCCCGCCGGTGGGGCCCCCGGGGCGAGCCGGGCGACGTAC
GCCGAGGCCGCGATCGCCGAGGTACGCCGGGCGCGCCAGGTGCTCGGCGACACCGATCTGCCGGTGAACACCGTCTTCTT
CGGCGGCGGCACCCCCACGCTGCTCGGCCCGGCCGACCTGGGGGCGGTGCTGGCCGCGATCGGCGCGGAGTTCGGGTTGG
CCGACGACGTGGAGGTCACGACCGAGGCGAACCCCGACAGCGTCGCCCTCTGGGACCTCGAGGAGCTCCGCGCTGCCGGG
TTCACCCGGCTCTCCTTCGGCATGCAGTCGGCGGTCGACCACGTGCTGCGGGTGCTGGATCGCACCCACGACCCGCTCCG
GGTGCCGGCGGTCGTCGACTGGGCGCGGCAGGCGGGCTTCGAGCAGATCAGCCTGGACCTGATCTACGGCACCCCGGGCG
AGTCCGTCGCCGACTGGGACGTCAGCGTCGAGGCCGCCCTCGCGTGCGGACCGGAGCACGTGTCGGCGTACTCCCTCATC
GTCGAGGAGGGCACCGCGCTGGCCCGCCGGGTCAAGCGGGGCGAGCTGCCGATGCCGGACGAGGACGACCTCGCCGACAA
GTACCTCCTGGTCGACGACCGGCTCGCCGCCGCTGGGCTGGAGTGGTACGAGGTGTCGAACTGGGCGCGCGGCCGCGACG
ACAACACGGCGAGCCGCTGTCGGCACAACCTCCTCTACTGGACCGGGGGCGACTGGTGGGGCGTCGGGCCGGGTGCGCAC
TCGCACGTCGGCGGGGTGCGGTGGTGGAACGTCAAGCACCCCGCGGCGTACGCCGAGCGGATCGCGGCCGGCCGGAGCCC
GGCCCACGCGCGGGAGGTCCTGGACGAGGAGAGCCGGCGGGTCGAGCGGGTGCTGCTCGAGCTCCGGCTGCGCGACGGCC
TGCCCGTCGAGGTCCTCGACGAGTCCGGCCGGGCGGCGGTCCCGGACCTCGTGGCCCGCGACCTGATCACCGAGCTGGCG
ACCGACGACGGGCACCGCCTGGTGCCCACCCGCCGCGGCCGGCTGCTCGCCGATGCGGTCGTGCGCGATCTCCTGCCGTG
A

Upstream 100 bases:

>100_bases
TCGCCGACCGGCTCGCCCCGATCGAGTCGGTCCACCCCGAGGCCGGCCAGGCCCTGCGCGCCCGGCACCGCTCCCGCGAC
TTCCAGTGATGGGGGGCTCG

Downstream 100 bases:

>100_bases
GGGCCCTCGCGGTCCTAGGGTGAAACCATGACCACAGGCCCAGAGAACCCGGATCCCTCGCAGCAGCCACAGGGCCAGCC
CGAAGGACAGTCGGCACCGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNTYTAEELGPAGGAPGASRATY
AEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADLGAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAG
FTRLSFGMQSAVDHVLRVLDRTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLI
VEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRCRHNLLYWTGGDWWGVGPGAH
SHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRRVERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELA
TDDGHRLVPTRRGRLLADAVVRDLLP

Sequences:

>Translated_426_residues
MRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNTYTAEELGPAGGAPGASRATY
AEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADLGAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAG
FTRLSFGMQSAVDHVLRVLDRTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLI
VEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRCRHNLLYWTGGDWWGVGPGAH
SHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRRVERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELA
TDDGHRLVPTRRGRLLADAVVRDLLP
>Mature_426_residues
MRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNTYTAEELGPAGGAPGASRATY
AEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADLGAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAG
FTRLSFGMQSAVDHVLRVLDRTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLI
VEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRCRHNLLYWTGGDWWGVGPGAH
SHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRRVERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELA
TDDGHRLVPTRRGRLLADAVVRDLLP

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=303, Percent_Identity=38.6138613861386, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1789325, Length=398, Percent_Identity=29.1457286432161, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI87082341, Length=430, Percent_Identity=28.8372093023256, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 45967; Mature: 45967

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCEEEEEECCCCCCC
YTAEELGPAGGAPGASRATYAEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADL
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECHHHH
GAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAGFTRLSFGMQSAVDHVLRVLD
HHHHHHHHHHCCCCCCCEEEECCCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLI
CCCCCEECHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEHHHHHCCCHHHHHHHHH
VEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRC
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHCCCCCCCCCCHHHHH
RHNLLYWTGGDWWGVGPGAHSHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRR
HCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
VERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELATDDGHRLVPTRRGRLLADAV
HHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHH
VRDLLP
HHHHCC
>Mature Secondary Structure
MRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCEEEEEECCCCCCC
YTAEELGPAGGAPGASRATYAEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADL
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECHHHH
GAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAGFTRLSFGMQSAVDHVLRVLD
HHHHHHHHHHCCCCCCCEEEECCCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLI
CCCCCEECHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEHHHHHCCCHHHHHHHHH
VEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRC
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHCCCCCCCCCCHHHHH
RHNLLYWTGGDWWGVGPGAHSHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRR
HCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
VERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELATDDGHRLVPTRRGRLLADAV
HHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHH
VRDLLP
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]