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The map label for this gene is maeB [C]

Identifier: 119715962

GI number: 119715962

Start: 1835522

End: 1836712

Strand: Direct

Name: maeB [C]

Synonym: Noca_1727

Alternate gene names: 119715962

Gene position: 1835522-1836712 (Clockwise)

Preceding gene: 119715961

Following gene: 119715963

Centisome position: 36.81

GC content: 72.54

Gene sequence:

>1191_bases
ATGGCCGAAGCAGAGTCCGCGAGCCCCCATCCGTACGCCGGAGACCCGGTCTTCGACCTCCATGTGGGCGGCAAGATGGC
GGTCAGGTCCTCCGTCGCGCTCGACGGGCCGGACGACCTGTCGAAGGCCTACACCCCGGGTGTGGCCCGGGTGTGCGAGG
CGATCGCGGAGGACCCGTCGCTGACCCAGCACTACACCTGGGTGCCCAACACCGTCGCGGTCGTCACCGACGGCACCGCC
GTCCTCGGGCTCGGTGACATCGGGCCGGCCGCGGCGATGCCCGTCATGGAGGGCAAGGCGGTGCTGTTCAAGCAGTTCGC
CGGCGTCGACGCCGTGCCGATCTGCCTGGACACCACCGACGCCGAGGAGATCATCGAGACCGTCGCCCGGCTGGCGCCGA
GCTTCGGTGGGATCAACCTCGAGGACATCTCGGCGCCGCGCTGCTTCGAGATCGAGGACCGGCTCAAGGAGCGGCTCGAC
ATCCCGGTCTTCCACGACGACCAGCACGGCACGGCCGTCGTCACGCTCGCCGCGCTCACCAACGCCCTCAAGCTGACCGG
CCGCAACCCGGAGTCGACCCGGGTGGTGATCTCCGGGGCCGGCGCCGCCGGCGTCGCCGTCGCCAAGATCCTGCTCGAGG
CCGGCATCAAGGACCTCGCCGTCACCGACCGCAAGGGCGTCCTCAACTCCGAGCGCGGCGACCTCACCCCGGTGAAGCGC
TCGCTCGCGGTGCTGACCGCCGACCGCAGCGGGCGCACCGGAAGCCTGGCCGACGTGCTGGCCGGAGCCGACGTCTACAT
CGGCGTGTCCGGCGGGACCGTGCCCGAGGAGTGGGTGGCCGCCATGGCCCCCGACGCGATCATCTTCGGGCTCGCGAACC
CGACGCCCGAGGTGCACCCCGAAGTGGCCCACCGGCACGCGCGGGTGGTGGCGACCGGACGCTCGGACTTCCCGAACCAG
ATCAACAACGTGCTCGCCTTCCCCGGCATCTTCCGGGGCGCCTTCGACGTCCACGCCACGGCCATCACCGAGGGCATGAA
GGTCGCCGCGGCCCAGGCGCTGGCCGACCTGGTCGGCGACGCGCTCGCCGAGGACATGGTCATCCCGTCGCCGTTCGACC
CCCGGGTCGGGCCGGCGGTGGCGGCGGCTGTGGCGGACGCCGCACGGCGCGACGGGGTGGCCCGCCGGTAG

Upstream 100 bases:

>100_bases
CGCCGGGAGAACCCCGGAGGACGAGGTTCCGCGCACCACCCCTGCGCGTCGAGCCGGACCTCCCCCACACGCCGCCCCAC
GGGAGAGTCAGAATCAGGTC

Downstream 100 bases:

>100_bases
GGACGGGTAGGTTCGGACAATGTTCGCCGTCTACGCCGACCGGTTCTCCAAGGACGACCCGCTCTCCGCCCTGCAGGTGG
GGGAGCGCCCGGATCCAGCG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAEAESASPHPYAGDPVFDLHVGGKMAVRSSVALDGPDDLSKAYTPGVARVCEAIAEDPSLTQHYTWVPNTVAVVTDGTA
VLGLGDIGPAAAMPVMEGKAVLFKQFAGVDAVPICLDTTDAEEIIETVARLAPSFGGINLEDISAPRCFEIEDRLKERLD
IPVFHDDQHGTAVVTLAALTNALKLTGRNPESTRVVISGAGAAGVAVAKILLEAGIKDLAVTDRKGVLNSERGDLTPVKR
SLAVLTADRSGRTGSLADVLAGADVYIGVSGGTVPEEWVAAMAPDAIIFGLANPTPEVHPEVAHRHARVVATGRSDFPNQ
INNVLAFPGIFRGAFDVHATAITEGMKVAAAQALADLVGDALAEDMVIPSPFDPRVGPAVAAAVADAARRDGVARR

Sequences:

>Translated_396_residues
MAEAESASPHPYAGDPVFDLHVGGKMAVRSSVALDGPDDLSKAYTPGVARVCEAIAEDPSLTQHYTWVPNTVAVVTDGTA
VLGLGDIGPAAAMPVMEGKAVLFKQFAGVDAVPICLDTTDAEEIIETVARLAPSFGGINLEDISAPRCFEIEDRLKERLD
IPVFHDDQHGTAVVTLAALTNALKLTGRNPESTRVVISGAGAAGVAVAKILLEAGIKDLAVTDRKGVLNSERGDLTPVKR
SLAVLTADRSGRTGSLADVLAGADVYIGVSGGTVPEEWVAAMAPDAIIFGLANPTPEVHPEVAHRHARVVATGRSDFPNQ
INNVLAFPGIFRGAFDVHATAITEGMKVAAAQALADLVGDALAEDMVIPSPFDPRVGPAVAAAVADAARRDGVARR
>Mature_395_residues
AEAESASPHPYAGDPVFDLHVGGKMAVRSSVALDGPDDLSKAYTPGVARVCEAIAEDPSLTQHYTWVPNTVAVVTDGTAV
LGLGDIGPAAAMPVMEGKAVLFKQFAGVDAVPICLDTTDAEEIIETVARLAPSFGGINLEDISAPRCFEIEDRLKERLDI
PVFHDDQHGTAVVTLAALTNALKLTGRNPESTRVVISGAGAAGVAVAKILLEAGIKDLAVTDRKGVLNSERGDLTPVKRS
LAVLTADRSGRTGSLADVLAGADVYIGVSGGTVPEEWVAAMAPDAIIFGLANPTPEVHPEVAHRHARVVATGRSDFPNQI
NNVLAFPGIFRGAFDVHATAITEGMKVAAAQALADLVGDALAEDMVIPSPFDPRVGPAVAAAVADAARRDGVARR

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=359, Percent_Identity=25.0696378830084, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI62420882, Length=396, Percent_Identity=25.2525252525253, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI62420880, Length=396, Percent_Identity=25.2525252525253, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI239049447, Length=396, Percent_Identity=25.2525252525253, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788806, Length=403, Percent_Identity=47.8908188585608, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI87081919, Length=437, Percent_Identity=29.0617848970252, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537199, Length=404, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=350, Percent_Identity=31.4285714285714, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78707232, Length=337, Percent_Identity=28.486646884273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363503, Length=337, Percent_Identity=28.486646884273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363505, Length=337, Percent_Identity=28.486646884273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78707236, Length=337, Percent_Identity=28.486646884273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646388, Length=392, Percent_Identity=28.3163265306122, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646386, Length=392, Percent_Identity=28.3163265306122, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 41018; Mature: 40887

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAESASPHPYAGDPVFDLHVGGKMAVRSSVALDGPDDLSKAYTPGVARVCEAIAEDPS
CCCCCCCCCCCCCCCCEEEEECCCCEEECCCEECCCCHHHHHHCCCHHHHHHHHHHCCCC
LTQHYTWVPNTVAVVTDGTAVLGLGDIGPAAAMPVMEGKAVLFKQFAGVDAVPICLDTTD
CCCEEEECCCEEEEEECCEEEEEECCCCCHHCCCHHCCHHHHHHHHCCCCCEEEEECCCC
AEEIIETVARLAPSFGGINLEDISAPRCFEIEDRLKERLDIPVFHDDQHGTAVVTLAALT
HHHHHHHHHHHCCCCCCCCHHHCCCCCEECHHHHHHHHCCCCEEECCCCCCCEEEHHHHH
NALKLTGRNPESTRVVISGAGAAGVAVAKILLEAGIKDLAVTDRKGVLNSERGDLTPVKR
HHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCHHHH
SLAVLTADRSGRTGSLADVLAGADVYIGVSGGTVPEEWVAAMAPDAIIFGLANPTPEVHP
HEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCCCH
EVAHRHARVVATGRSDFPNQINNVLAFPGIFRGAFDVHATAITEGMKVAAAQALADLVGD
HHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEDMVIPSPFDPRVGPAVAAAVADAARRDGVARR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AEAESASPHPYAGDPVFDLHVGGKMAVRSSVALDGPDDLSKAYTPGVARVCEAIAEDPS
CCCCCCCCCCCCCCCEEEEECCCCEEECCCEECCCCHHHHHHCCCHHHHHHHHHHCCCC
LTQHYTWVPNTVAVVTDGTAVLGLGDIGPAAAMPVMEGKAVLFKQFAGVDAVPICLDTTD
CCCEEEECCCEEEEEECCEEEEEECCCCCHHCCCHHCCHHHHHHHHCCCCCEEEEECCCC
AEEIIETVARLAPSFGGINLEDISAPRCFEIEDRLKERLDIPVFHDDQHGTAVVTLAALT
HHHHHHHHHHHCCCCCCCCHHHCCCCCEECHHHHHHHHCCCCEEECCCCCCCEEEHHHHH
NALKLTGRNPESTRVVISGAGAAGVAVAKILLEAGIKDLAVTDRKGVLNSERGDLTPVKR
HHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCCHHHH
SLAVLTADRSGRTGSLADVLAGADVYIGVSGGTVPEEWVAAMAPDAIIFGLANPTPEVHP
HEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCCCH
EVAHRHARVVATGRSDFPNQINNVLAFPGIFRGAFDVHATAITEGMKVAAAQALADLVGD
HHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEDMVIPSPFDPRVGPAVAAAVADAARRDGVARR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]