Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 119715945

GI number: 119715945

Start: 1813807

End: 1815462

Strand: Reverse

Name: ilvG [H]

Synonym: Noca_1710

Alternate gene names: 119715945

Gene position: 1815462-1813807 (Counterclockwise)

Preceding gene: 119715946

Following gene: 119715944

Centisome position: 36.41

GC content: 74.76

Gene sequence:

>1656_bases
ATGTCCACGGAAGTGAACGGCCACGCCGGCGAGCTCGCGGTCGCGGTCGCACAGGCCCACGGGGTCGAGACCATGTTCAC
CCTGTCCGGCGCGCACGTCTTCCCGCTGTACGACGGCGCCGTGAAGTCGGCGACGCCGCTGCGGCTGCTCGACGTACGCC
ACGAGCAGACCGCCGCGTTCGCCGCCGAGGCGACCGGCAAGCTGACCCGAGTCCCCGGTCTCGCGGTGCTCACCGCGGGT
CCCGGCGTGACCAACGGGCTCAGCGCGGTCGCGCAGGCACAGTTCGCCGGGTCGCCGATGGTCGTCGTCGGCGGCCGCGC
CCCGCAGGGCCGCTGGGGCACCGGCGCCCTCCAGGAGCTCGACCAGCCTCCGATCCTCGCGCCGGTCTCGAAGCTGGCGC
GCACGATCCCGACCGCGGGCGAAGTGCTTGGCGGCATGCACCAAGCCTTCGTCACCGCCGGCTCTCCGCACCGCGGCCCG
GTGTTCGTGGACGTGCCGATGGACGAGCTGTTCAACAGCGCCGGCGGGCCGCTCCCGGACGTGACCGCGCCCCGCGGCGC
CGAGCCGGACTCCGATGCGATCACCGAGGTCGCCGAGCTCCTGGCCGCCGCCGCGCGACCGGTGCTGATCCTGGGCACCG
ACGTGTGGGCCGACCGCGCCGAGGAGGCCGCGCTGCGCTTCGTCGAGGCCGTCGGCATCCCGACGATCACCAACGGCATG
GGCCGCGGCGTCGTCCCCGGCGGCCACCCGCTGCTGGTCACCAAGGCCCGCGGCCAGGCCCTCGGCGGCAGCGACCTGGT
CGTGGTCGTCGGCACGCCGCTGGACTTCCGGCTCGGATACGGCATCTTCGGCGGCGCGGACGGCGCCACGCCGGCCCAGG
TCGTGCACGTCGCCGACTCCCCCGGTCAGCTCTCCGGTCACGCGGCGCTCGCGGCCTCGGTCTCCGGCGACCTGTCCAGC
GTCTTCGACGGGCTGCTCGCCGCCATGGAGCAGGTCGTGCGGCGGCCGGACTGGTCCGGCTGGGTCGGCGATCTCGGGGC
AGCGGTCGCCGCGGCGGTCGAGCGGGACGCCGCGCTGCTCGGCGCCGAGGCGGACCCGATCCACCCGGCCCGGATCTACG
GCGACCTGGTCCCCCGGCTCGCCGAGGACGCGGTCGTGATCGGCGACGGCGGTGACTTCGTCAGCTTCGCGGGCAAGTTC
GTCGAGCCCAAGCGCCCCGGCGGCTGGCTCGACCCGGGCCCGTACGGCTGTCTCGGCGCCGGCCTGGGGGCGGCGATCGC
CGCCCGGCTGGCCCGGCCCTCGGCGCAGGTGGTGCTGCTGCTCGGCGACGGGGCGGCGGGCTTCTCGCTGATGGACGTGG
ACACTCTGGTGCGCCACCACCTGCCGGTGGTCATGGTGATGGGCAACAACTCCGCCTGGGGCCTGGAGAAGGGCCCGATG
CAGATGCTCTACGGGTACGACGTGATCGCCGACCTCGCGCCCCGTACGGCGTACGACCAGGTGGTCCGCGCGCTCGGCGG
CGCCGGCGAGACGGTCACCGACCCCCGCGAGGTCGGCCCGGCGCTGGACCGCGCGTTCGCCTCCGGGGTGCCCTACCTGG
TCAACGTCATCACCGACGTCACCGCGACCTACCCGCGGAACAGCTTCGGTGTCTGA

Upstream 100 bases:

>100_bases
CCCCCGCAGGTCCGCTCCGACCTGCTCCTGGTGGTGCTCGACGCGCTCAAGTCCACCAACGCCGCGTACCTCGCACCTAC
GGGTGAGTAACCTTCGCAGC

Downstream 100 bases:

>100_bases
GCCGGCCGACGTCGTCGTCCGCCGCGCCCAGCCCGGCGACCTGGCGACGGCGGGCGACGTCACGGTCGCGGCGTACACCG
AGTTCACCCTCGGCCCCGAG

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSTEVNGHAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAFAAEATGKLTRVPGLAVLTAG
PGVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQELDQPPILAPVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGP
VFVDVPMDELFNSAGGPLPDVTAPRGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGM
GRGVVPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADSPGQLSGHAALAASVSGDLSS
VFDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALLGAEADPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKF
VEPKRPGGWLDPGPYGCLGAGLGAAIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPM
QMLYGYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDVTATYPRNSFGV

Sequences:

>Translated_551_residues
MSTEVNGHAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAFAAEATGKLTRVPGLAVLTAG
PGVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQELDQPPILAPVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGP
VFVDVPMDELFNSAGGPLPDVTAPRGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGM
GRGVVPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADSPGQLSGHAALAASVSGDLSS
VFDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALLGAEADPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKF
VEPKRPGGWLDPGPYGCLGAGLGAAIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPM
QMLYGYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDVTATYPRNSFGV
>Mature_550_residues
STEVNGHAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAFAAEATGKLTRVPGLAVLTAGP
GVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQELDQPPILAPVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGPV
FVDVPMDELFNSAGGPLPDVTAPRGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGMG
RGVVPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADSPGQLSGHAALAASVSGDLSSV
FDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALLGAEADPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKFV
EPKRPGGWLDPGPYGCLGAGLGAAIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPMQ
MLYGYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDVTATYPRNSFGV

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=580, Percent_Identity=31.0344827586207, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI93004078, Length=562, Percent_Identity=26.8683274021352, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1788716, Length=542, Percent_Identity=28.9667896678967, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790104, Length=557, Percent_Identity=26.032315978456, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI87081685, Length=536, Percent_Identity=25.9328358208955, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1786717, Length=560, Percent_Identity=26.0714285714286, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1787096, Length=537, Percent_Identity=23.2774674115456, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17542570, Length=557, Percent_Identity=33.572710951526, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17531301, Length=564, Percent_Identity=26.7730496453901, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=564, Percent_Identity=26.7730496453901, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320816, Length=550, Percent_Identity=26.5454545454545, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323755, Length=559, Percent_Identity=24.3291592128801, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=27.2727272727273, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 56168; Mature: 56036

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEVNGHAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAF
CCCCCCCCCCHHEEEEHHHCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCHHHHHHH
AAEATGKLTRVPGLAVLTAGPGVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQEL
HHHHCCCEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHC
DQPPILAPVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGPVFVDVPMDELFNSAGGPLPD
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCEEEECCHHHHHHHCCCCCCC
VTAPRGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGM
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
GRGVVPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADS
CCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCEECCCCCCCCEEEEEEECC
PGQLSGHAALAASVSGDLSSVFDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALL
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GAEADPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKFVEPKRPGGWLDPGPYGCLGA
CCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
GLGAAIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPM
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCH
QMLYGYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDV
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
TATYPRNSFGV
HHCCCCCCCCC
>Mature Secondary Structure 
STEVNGHAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAF
CCCCCCCCCHHEEEEHHHCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCHHHHHHH
AAEATGKLTRVPGLAVLTAGPGVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQEL
HHHHCCCEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHC
DQPPILAPVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGPVFVDVPMDELFNSAGGPLPD
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCEEEECCHHHHHHHCCCCCCC
VTAPRGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGM
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
GRGVVPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADS
CCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCEECCCCCCCCEEEEEEECC
PGQLSGHAALAASVSGDLSSVFDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALL
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GAEADPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKFVEPKRPGGWLDPGPYGCLGA
CCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
GLGAAIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPM
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCH
QMLYGYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDV
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
TATYPRNSFGV
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]