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The map label for this gene is hisN [H]

Identifier: 119715932

GI number: 119715932

Start: 1803313

End: 1804188

Strand: Reverse

Name: hisN [H]

Synonym: Noca_1697

Alternate gene names: 119715932

Gene position: 1804188-1803313 (Counterclockwise)

Preceding gene: 119715934

Following gene: 119715931

Centisome position: 36.19

GC content: 72.72

Gene sequence:

>876_bases
GTGCCGATCTCCACGGACTACACGGACGACCTGCGGCTCGCCCACGTCCTCGCCGACGATGCCGACTCCCTGACCGAGGC
CCGCTACAAGGCCCTCGACCTGCACGTGATGAGCAAGCCCGACCTGACGCCGGTCACCGACGCCGACCAGGCGGTCGAGG
AGAGCATCCGGCGCACGCTGTCCCGGGTGCGCTCTCGCGACGCCGTCACGGGCGAGGAGCAGGGCTCCACCGGCCACAGC
CAGCGGCGCTGGGTCATCGACCCGATCGACGGCACCAAGAACTTCGTCCGCGGCGTCCCGGTGTGGGCCACGCTGATCTC
CCTGGTCGTCGACGACCAGGTGGTGGTCGGCGTCGTCTCCGCTCCGCTGCTCCAGCGCCGCTGGTGGGCGTCGATCGGCA
GCGGCGCATGGACCGGCCGGTCGCTGCTCAAGGCGACCCGCTGCCAGGTGTCCGACGTCCGCCGCCTCGAGGACGCCTCG
CTCTCCTACGCCTCCTTGCACGGGTGGGACGAGCGCGACCGGCTCGACGACTTCCTGTCCCTGATGCGCCGCTGCTGGCG
CACCCGGGCGTACGGCGACTTCTGGTCCTACATGCTGCTCGCCGAGGGGGCGGTCGACATCGCGGCCGAGCCCGAGCTCG
CCATCTACGACATGGCCGCGCTGGCGGTGATCGTCAGCGAGGCGGGCGGCCGGTTCACCTCCCTGGACGGCACCGACGGA
CCGTTCGGCGGCAACGCGCTCGCCACGAACGGCCACCTCCACGAGGCCGCCCTCTCGTTCCTCGCGGCGCTCCCCGACGA
CGAGGACGACCCCGACTCGCGGCGCACCGGCCCCGGCTCGGTCTCCGACCTGCGGCTGCACCGCCCCCGGGACTGA

Upstream 100 bases:

>100_bases
CGGCGGCGTGCACGACCAGGGGATGCAGCGGGAGCCCATTGATCTCCATGACCTGTACACGGACCACCACGCCGGATCGT
TCAGTCACTAGGCTGACGGT

Downstream 100 bases:

>100_bases
CGTCAGGGACGGCACCCGGCTCCCGGGACCGGCCGCTGGCTGGACGCAGGGGTGTACGGGTGACCGGACCGACCAGTACG
GTCTGCGCATAGGTCGGCCA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPISTDYTDDLRLAHVLADDADSLTEARYKALDLHVMSKPDLTPVTDADQAVEESIRRTLSRVRSRDAVTGEEQGSTGHS
QRRWVIDPIDGTKNFVRGVPVWATLISLVVDDQVVVGVVSAPLLQRRWWASIGSGAWTGRSLLKATRCQVSDVRRLEDAS
LSYASLHGWDERDRLDDFLSLMRRCWRTRAYGDFWSYMLLAEGAVDIAAEPELAIYDMAALAVIVSEAGGRFTSLDGTDG
PFGGNALATNGHLHEAALSFLAALPDDEDDPDSRRTGPGSVSDLRLHRPRD

Sequences:

>Translated_291_residues
MPISTDYTDDLRLAHVLADDADSLTEARYKALDLHVMSKPDLTPVTDADQAVEESIRRTLSRVRSRDAVTGEEQGSTGHS
QRRWVIDPIDGTKNFVRGVPVWATLISLVVDDQVVVGVVSAPLLQRRWWASIGSGAWTGRSLLKATRCQVSDVRRLEDAS
LSYASLHGWDERDRLDDFLSLMRRCWRTRAYGDFWSYMLLAEGAVDIAAEPELAIYDMAALAVIVSEAGGRFTSLDGTDG
PFGGNALATNGHLHEAALSFLAALPDDEDDPDSRRTGPGSVSDLRLHRPRD
>Mature_290_residues
PISTDYTDDLRLAHVLADDADSLTEARYKALDLHVMSKPDLTPVTDADQAVEESIRRTLSRVRSRDAVTGEEQGSTGHSQ
RRWVIDPIDGTKNFVRGVPVWATLISLVVDDQVVVGVVSAPLLQRRWWASIGSGAWTGRSLLKATRCQVSDVRRLEDASL
SYASLHGWDERDRLDDFLSLMRRCWRTRAYGDFWSYMLLAEGAVDIAAEPELAIYDMAALAVIVSEAGGRFTSLDGTDGP
FGGNALATNGHLHEAALSFLAALPDDEDDPDSRRTGPGSVSDLRLHRPRD

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=267, Percent_Identity=27.7153558052434, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221625487, Length=268, Percent_Identity=27.6119402985075, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788882, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193202572, Length=208, Percent_Identity=30.2884615384615, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193202570, Length=256, Percent_Identity=30.46875, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357957, Length=251, Percent_Identity=25.8964143426295, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664918, Length=212, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664922, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21357303, Length=198, Percent_Identity=28.2828282828283, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357329, Length=253, Percent_Identity=27.6679841897233, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24664926, Length=203, Percent_Identity=27.0935960591133, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 32048; Mature: 31917

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISTDYTDDLRLAHVLADDADSLTEARYKALDLHVMSKPDLTPVTDADQAVEESIRRTL
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHH
SRVRSRDAVTGEEQGSTGHSQRRWVIDPIDGTKNFVRGVPVWATLISLVVDDQVVVGVVS
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHH
APLLQRRWWASIGSGAWTGRSLLKATRCQVSDVRRLEDASLSYASLHGWDERDRLDDFLS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
LMRRCWRTRAYGDFWSYMLLAEGAVDIAAEPELAIYDMAALAVIVSEAGGRFTSLDGTDG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
PFGGNALATNGHLHEAALSFLAALPDDEDDPDSRRTGPGSVSDLRLHRPRD
CCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PISTDYTDDLRLAHVLADDADSLTEARYKALDLHVMSKPDLTPVTDADQAVEESIRRTL
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHH
SRVRSRDAVTGEEQGSTGHSQRRWVIDPIDGTKNFVRGVPVWATLISLVVDDQVVVGVVS
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHH
APLLQRRWWASIGSGAWTGRSLLKATRCQVSDVRRLEDASLSYASLHGWDERDRLDDFLS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
LMRRCWRTRAYGDFWSYMLLAEGAVDIAAEPELAIYDMAALAVIVSEAGGRFTSLDGTDG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
PFGGNALATNGHLHEAALSFLAALPDDEDDPDSRRTGPGSVSDLRLHRPRD
CCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]