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The map label for this gene is gdh [H]

Identifier: 119715893

GI number: 119715893

Start: 1762485

End: 1763861

Strand: Direct

Name: gdh [H]

Synonym: Noca_1658

Alternate gene names: 119715893

Gene position: 1762485-1763861 (Clockwise)

Preceding gene: 119715892

Following gene: 119715896

Centisome position: 35.35

GC content: 69.06

Gene sequence:

>1377_bases
ATGGTCGCCACTGCAACTCCGGGCCACGACGTCTCCGCGCTGCACCCCGAGCTCCGCCCGATGTACGAGAAGGTCGTGAG
CCGCAACCCCGGGGAGCGGGAGTTCCACCAGGCCGTCTTCGAGGTGATGCAGAGCGTCGGCCCGATCGCCGAGGAGCGCT
CGGACTACGCCCAGTGGTCGATCCTGCAGCGGATCTGCGAGCCCGAGCGCCAGATCATCTTCCGGGTGCCGTGGGTCGCC
GACGACGGCAAGGTCGAGATCAACCGGGGCTTCAGGGTGGAGTTCAACTCGGCCCTCGGCCCCTTCAAGGGTGGCCTGCG
CTTCCACCCGAGCGTGAACCTGTCGATCATCAAGTTCCTCGGCTTCGAGCAGGTCTTCAAGAACGCCCTCACCGGCATGC
CGATCGGCGGGGGCAAGGGTGGCGCCGACTTCGACCCGAAGGGCCGCTCGGACGGCGAGGTGATGCGGTTCTGCCAGTCG
TTCATGACCGAGCTCTACCGGCACGTCGGTGAGTACACCGACGTGCCCGCGGGCGACATCGGTGTCGGTGGGCGGGAGAT
CGGCTACCTGTTCGGGCAGTACAAGCGGATCACGAACCGGTACGAGTCCGGCGTCATCACGGGCAAGGGCCTGACCTGGG
GCGGGTCGCAGGTGCGCACCGAGGCGACCGGCTACGGCACGGTCTTCTTCGTCGAGCAGATGCTGCAGGCCCGCGGCGAG
CACCTCGAGGGCAAGCGCGTGGTCGTCTCCGGTGCGGGCAACGTGGCCATCTACGCGGTCGAGAAGGCGCAGGCCCTCGG
CGCCGTCGTCGTCGCGGTGTCCGACTCGGGCGGGTACGTCGTGGACGAGGCCGGCATCGACCTCGAGCTCCTCAAGGAGA
TCAAGGAGGTCGAGCGCGGACGCCTGACGGAGTACGTCGAGCGTCGGTCCGGGGCGACCCACGTCACGGATGGCTGCATC
TGGGACGTCCCCTGCGACATCGCGCTCCCGTGCGCCACCCAGAACGAGCTCGACGAGTCCGCCGCGAAGACGCTCGCGGC
GAACGGCGTGACGCTGGTGGCGGAGGGCGCGAACATGCCCAGCACCCCGGCAGCCGTGCAGCTCTTCCAGGCGGCCGGGG
TGCTCTTCGCGCCCGGCAAGGCCTCGAACGCCGGCGGGGTCGCGACCAGTGCGCTGGAGATGCAGCAGAACGCCTCGCGC
GACTCCTGGCACTTCGACGAGACCGAGGCTCGGCTGCAGGAGATCATGAGCGAGATCCACGACACCTGCCTGGCGACCAG
CGACCACTACGGCGCGCCCGGCAACTACGTCGTCGGCGCCAACCTCGCCGGCTACGTCAGGGTGGCCGACGCGATGGTGG
CCCTCGGCGTGATCTGA

Upstream 100 bases:

>100_bases
GAAGCCGCCCCGACGCCCGGAGTGAGCCAGGACACGGGAAGTGACTCAGAGGGTAAGACCCGGTCTCACCACCGGGGCGG
AGGCCCCTAGGCTCGCACGC

Downstream 100 bases:

>100_bases
GCCGACCGGAGAGACGGCTACCGGGAGACGACCGAGCGCAGGGCGCGCGCCGCACTCGGACGCTGCGGCTGGGGCCGGAG
CGGCAGCGGGATCACCACCG

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MVATATPGHDVSALHPELRPMYEKVVSRNPGEREFHQAVFEVMQSVGPIAEERSDYAQWSILQRICEPERQIIFRVPWVA
DDGKVEINRGFRVEFNSALGPFKGGLRFHPSVNLSIIKFLGFEQVFKNALTGMPIGGGKGGADFDPKGRSDGEVMRFCQS
FMTELYRHVGEYTDVPAGDIGVGGREIGYLFGQYKRITNRYESGVITGKGLTWGGSQVRTEATGYGTVFFVEQMLQARGE
HLEGKRVVVSGAGNVAIYAVEKAQALGAVVVAVSDSGGYVVDEAGIDLELLKEIKEVERGRLTEYVERRSGATHVTDGCI
WDVPCDIALPCATQNELDESAAKTLAANGVTLVAEGANMPSTPAAVQLFQAAGVLFAPGKASNAGGVATSALEMQQNASR
DSWHFDETEARLQEIMSEIHDTCLATSDHYGAPGNYVVGANLAGYVRVADAMVALGVI

Sequences:

>Translated_458_residues
MVATATPGHDVSALHPELRPMYEKVVSRNPGEREFHQAVFEVMQSVGPIAEERSDYAQWSILQRICEPERQIIFRVPWVA
DDGKVEINRGFRVEFNSALGPFKGGLRFHPSVNLSIIKFLGFEQVFKNALTGMPIGGGKGGADFDPKGRSDGEVMRFCQS
FMTELYRHVGEYTDVPAGDIGVGGREIGYLFGQYKRITNRYESGVITGKGLTWGGSQVRTEATGYGTVFFVEQMLQARGE
HLEGKRVVVSGAGNVAIYAVEKAQALGAVVVAVSDSGGYVVDEAGIDLELLKEIKEVERGRLTEYVERRSGATHVTDGCI
WDVPCDIALPCATQNELDESAAKTLAANGVTLVAEGANMPSTPAAVQLFQAAGVLFAPGKASNAGGVATSALEMQQNASR
DSWHFDETEARLQEIMSEIHDTCLATSDHYGAPGNYVVGANLAGYVRVADAMVALGVI
>Mature_458_residues
MVATATPGHDVSALHPELRPMYEKVVSRNPGEREFHQAVFEVMQSVGPIAEERSDYAQWSILQRICEPERQIIFRVPWVA
DDGKVEINRGFRVEFNSALGPFKGGLRFHPSVNLSIIKFLGFEQVFKNALTGMPIGGGKGGADFDPKGRSDGEVMRFCQS
FMTELYRHVGEYTDVPAGDIGVGGREIGYLFGQYKRITNRYESGVITGKGLTWGGSQVRTEATGYGTVFFVEQMLQARGE
HLEGKRVVVSGAGNVAIYAVEKAQALGAVVVAVSDSGGYVVDEAGIDLELLKEIKEVERGRLTEYVERRSGATHVTDGCI
WDVPCDIALPCATQNELDESAAKTLAANGVTLVAEGANMPSTPAAVQLFQAAGVLFAPGKASNAGGVATSALEMQQNASR
DSWHFDETEARLQEIMSEIHDTCLATSDHYGAPGNYVVGANLAGYVRVADAMVALGVI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=356, Percent_Identity=29.7752808988764, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4885281, Length=356, Percent_Identity=29.7752808988764, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1788059, Length=444, Percent_Identity=58.5585585585586, Blast_Score=513, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17544676, Length=372, Percent_Identity=27.9569892473118, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319256, Length=461, Percent_Identity=48.8069414316703, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324951, Length=452, Percent_Identity=47.5663716814159, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24649283, Length=368, Percent_Identity=30.4347826086957, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45549226, Length=356, Percent_Identity=28.9325842696629, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45553475, Length=356, Percent_Identity=28.9325842696629, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24649460, Length=292, Percent_Identity=28.7671232876712, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49360; Mature: 49360

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATATPGHDVSALHPELRPMYEKVVSRNPGEREFHQAVFEVMQSVGPIAEERSDYAQWS
CCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILQRICEPERQIIFRVPWVADDGKVEINRGFRVEFNSALGPFKGGLRFHPSVNLSIIKFL
HHHHHHCCCCEEEEECCEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCHHHHHHH
GFEQVFKNALTGMPIGGGKGGADFDPKGRSDGEVMRFCQSFMTELYRHVGEYTDVPAGDI
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GVGGREIGYLFGQYKRITNRYESGVITGKGLTWGGSQVRTEATGYGTVFFVEQMLQARGE
CCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
HLEGKRVVVSGAGNVAIYAVEKAQALGAVVVAVSDSGGYVVDEAGIDLELLKEIKEVERG
CCCCCEEEEECCCCEEEEEEHHHHCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHH
RLTEYVERRSGATHVTDGCIWDVPCDIALPCATQNELDESAAKTLAANGVTLVAEGANMP
HHHHHHHHCCCCCCCCCCEEECCCCCCEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
STPAAVQLFQAAGVLFAPGKASNAGGVATSALEMQQNASRDSWHFDETEARLQEIMSEIH
CCHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
DTCLATSDHYGAPGNYVVGANLAGYVRVADAMVALGVI
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVATATPGHDVSALHPELRPMYEKVVSRNPGEREFHQAVFEVMQSVGPIAEERSDYAQWS
CCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILQRICEPERQIIFRVPWVADDGKVEINRGFRVEFNSALGPFKGGLRFHPSVNLSIIKFL
HHHHHHCCCCEEEEECCEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCHHHHHHH
GFEQVFKNALTGMPIGGGKGGADFDPKGRSDGEVMRFCQSFMTELYRHVGEYTDVPAGDI
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GVGGREIGYLFGQYKRITNRYESGVITGKGLTWGGSQVRTEATGYGTVFFVEQMLQARGE
CCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
HLEGKRVVVSGAGNVAIYAVEKAQALGAVVVAVSDSGGYVVDEAGIDLELLKEIKEVERG
CCCCCEEEEECCCCEEEEEEHHHHCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHH
RLTEYVERRSGATHVTDGCIWDVPCDIALPCATQNELDESAAKTLAANGVTLVAEGANMP
HHHHHHHHCCCCCCCCCCEEECCCCCCEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
STPAAVQLFQAAGVLFAPGKASNAGGVATSALEMQQNASRDSWHFDETEARLQEIMSEIH
CCHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
DTCLATSDHYGAPGNYVVGANLAGYVRVADAMVALGVI
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]