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The map label for this gene is hemL [H]

Identifier: 119715891

GI number: 119715891

Start: 1758820

End: 1761081

Strand: Reverse

Name: hemL [H]

Synonym: Noca_1656

Alternate gene names: 119715891

Gene position: 1761081-1758820 (Counterclockwise)

Preceding gene: 119715894

Following gene: 119715890

Centisome position: 35.32

GC content: 70.82

Gene sequence:

>2262_bases
GTGCTGCACGTTCCCTCGAGGCGACACGTCGTCGACATGTGTCGCACGCTCTTGGAGCGCGGCTACCTCAAGGCCACCGA
GGGAAACATCTCCGTGCGCGTGCCCGGTCACGACCGGTTCGCCGTGACGCCGAGCAACTACGACTACGCCAAGATGCGCC
CCGAGGACATCTGCATCCTCGACTTCGAGGGGAAGGTCGTGGCGGAGGCGGGCGGCTCCGACCTCCCCCCGACCGTCGAG
TCCGGGCTCCACGCAGCGGTCTACCGCGAGCGTCCCGACGTGCATGCGGTCGTCCACACCCATCAGCCGTACGCCTCGGC
CCTGGCCTTCCTGAGGCGGCCGATCCCGGCGCTCACCGACGAGCAGGTGCGGTTCCTCGGTCGCGAGGTGGCCATCATCG
ACTACGCGCCCGCCGGCACCTCGTTCCTGGCCAAGAACGTGGCGAAGCGCCTCGGGTCCTCGGCCAACGCCTTCATCATC
GCCAACCACGGCATCCTGGCCGTCGGCACCGACCCCGACCGGGCGATCTTCAACATGGCGCTGCTCGAGAAGGTCTGCCT
CGCCTACCTCCTGGCGCTCACGACCGAGACCGGCCGGGTCTACACGATCCCCTCGGCGATCCGGGAGATCGCACTCACCA
AGCTCAAGAGTGACCAGAAGCGGATCGCGGCGCAGGTCGAGCAGTTCGTACCCGTCGACCGGGACCTGGTCGAGGAGCCG
CTGCCCAGCGCCGACGCGGTGGCCGAGCGGGTCCGGACGGCTCCGGGCGCGGGTCCGGAGGTTGCGGCGCCCGGGGCGGC
CCCGGGAGCGGCGGACCTGGGCTACGCGATCAGCGACTACCCGGACGTCGACGCCGTGATGCGGCGGATCAAGGCACTGA
CCGGTCAACCGGTCCGCGGCCTGAGGCACGACGCCCTCCTCGACGTGCTCGCCTGGTTCGACACCAAGTGCGCCGCGAGC
AAGGAGCTCACCGACCGGGCCAAGGCCCGGATCCCGGGAGGCGTGCAGCACAACCTCGCGTTCAACTACCCCTTCCCCCT
CGCCATCGACCGCGCCGATGGCGCGCACCTGACCGACCGGGACGGGAACGTCTACGTCGACTTCCTCCAAGCGGGCGGGC
CGACGATCCTCGGCAGCAACTACGGGCCGGTGAACGAGCAGGTGGCGGAGGTGATCCGCGAGTCCGGGCCGGTGACGGGC
CTCTTCCACGAGTACGAGCTCAAGCTCGCGGAGTCGATCAACCGGTACCTGCCCCACATCGAGATGTACCGGTCCCTCGG
CTCCGGCACCGAGGCCGTGATGGCCGCCGTCCGCGCGGCTCGCGTGAAGACCGGCAAGCACATGGTGATCAAGGTCGGTG
GCGCCTACCACGGCTGGTCCGACTCGATGGTCTACGGGCTCCGCGTCCCCGGGACCTTCCGGATGAACGCGAAGGGCATC
CCGTTCGGCGCCACCGCGGGGACGCGCGAGAGCTTCCCCCACGACGTGGGGCAGCTGCGCCGCAAGCTGATCGAGAACCG
GGCCCGCGGCGGCACGGCCGCGGTGATCGTGGAGCCCCTCGGGCCCGAGTCCGGGACCCGGCCGGCGCCGCGCGACTACA
ACGCCCGGGTCCGGGAGCTCTGCGACGAGTTCGGTGCGCTGCTGATCTTCGACGAGGTGGTCACCGGCTTCCGGGTCGGC
ATGGGTGGTGCCGCCGGCTACTTCGGGGTCACCCCCGACCTGACCGTCCTCGGCAAGGCCGTGGCCGGCGGGTACCCGAT
GGCGGGCGGCGTCGGCGGGAGCGCGGAGGTGATGTCGGTGTTCGGCTCCGGGCTGGACGGCAAGAACGGCGCCCACGTGC
TGGTCGGCGGCACGCTGTCGGCCAACCCGCTGTCCTGCGCGGCGGGGCACTTCGCGATCGAGGAGATGGCGCGCACCAAC
GCGCCCGTGGTCGCGGGCGCCGCGGGCGACCGCCTCGCGCGCGGGCTGCAGCGACTGATCGACCACTACGGCCTGCCGTA
CGTCGCCTACAACCAGGGCTCGATCGTGCACCTGCAGTCCAGCGGCGTGCTGCTGCTCGACATGCGCAACCCGGTCAAGC
TGCTCAAGGAGAGCAAGCCGCGCAAGCACCTGATGGAGCAGCTGGGCGCGGCGTACGCCGCCCACGGCATCATCACGCTG
GCCGGCTCCCGCCTGTACACCTCGATGGCCGACACCGACGAGGTCATCGACGACGCGCTCGAGCGGTTCGACCGGGTCTT
CGCCCTCGTCGAGGGCGTGTGA

Upstream 100 bases:

>100_bases
TGACAACTCCGGCCGACCGGATCGCTACCGGCGACGGGTCGCCAGTTCCCCCGCCTCCGGCCATCCTGGCATCAGACACC
TTTCGTGGATGGAGGCCGGT

Downstream 100 bases:

>100_bases
CGCCGCCATCGGCCCTGTCAGCGCCGGGGCCGGCACCGGGGTCGGGGCCGTACCTGATCGGCGTCGACCTCGGCACCGGC
GGACCCAAGGTCGCCCTCAC

Product: aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MLHVPSRRHVVDMCRTLLERGYLKATEGNISVRVPGHDRFAVTPSNYDYAKMRPEDICILDFEGKVVAEAGGSDLPPTVE
SGLHAAVYRERPDVHAVVHTHQPYASALAFLRRPIPALTDEQVRFLGREVAIIDYAPAGTSFLAKNVAKRLGSSANAFII
ANHGILAVGTDPDRAIFNMALLEKVCLAYLLALTTETGRVYTIPSAIREIALTKLKSDQKRIAAQVEQFVPVDRDLVEEP
LPSADAVAERVRTAPGAGPEVAAPGAAPGAADLGYAISDYPDVDAVMRRIKALTGQPVRGLRHDALLDVLAWFDTKCAAS
KELTDRAKARIPGGVQHNLAFNYPFPLAIDRADGAHLTDRDGNVYVDFLQAGGPTILGSNYGPVNEQVAEVIRESGPVTG
LFHEYELKLAESINRYLPHIEMYRSLGSGTEAVMAAVRAARVKTGKHMVIKVGGAYHGWSDSMVYGLRVPGTFRMNAKGI
PFGATAGTRESFPHDVGQLRRKLIENRARGGTAAVIVEPLGPESGTRPAPRDYNARVRELCDEFGALLIFDEVVTGFRVG
MGGAAGYFGVTPDLTVLGKAVAGGYPMAGGVGGSAEVMSVFGSGLDGKNGAHVLVGGTLSANPLSCAAGHFAIEEMARTN
APVVAGAAGDRLARGLQRLIDHYGLPYVAYNQGSIVHLQSSGVLLLDMRNPVKLLKESKPRKHLMEQLGAAYAAHGIITL
AGSRLYTSMADTDEVIDDALERFDRVFALVEGV

Sequences:

>Translated_753_residues
MLHVPSRRHVVDMCRTLLERGYLKATEGNISVRVPGHDRFAVTPSNYDYAKMRPEDICILDFEGKVVAEAGGSDLPPTVE
SGLHAAVYRERPDVHAVVHTHQPYASALAFLRRPIPALTDEQVRFLGREVAIIDYAPAGTSFLAKNVAKRLGSSANAFII
ANHGILAVGTDPDRAIFNMALLEKVCLAYLLALTTETGRVYTIPSAIREIALTKLKSDQKRIAAQVEQFVPVDRDLVEEP
LPSADAVAERVRTAPGAGPEVAAPGAAPGAADLGYAISDYPDVDAVMRRIKALTGQPVRGLRHDALLDVLAWFDTKCAAS
KELTDRAKARIPGGVQHNLAFNYPFPLAIDRADGAHLTDRDGNVYVDFLQAGGPTILGSNYGPVNEQVAEVIRESGPVTG
LFHEYELKLAESINRYLPHIEMYRSLGSGTEAVMAAVRAARVKTGKHMVIKVGGAYHGWSDSMVYGLRVPGTFRMNAKGI
PFGATAGTRESFPHDVGQLRRKLIENRARGGTAAVIVEPLGPESGTRPAPRDYNARVRELCDEFGALLIFDEVVTGFRVG
MGGAAGYFGVTPDLTVLGKAVAGGYPMAGGVGGSAEVMSVFGSGLDGKNGAHVLVGGTLSANPLSCAAGHFAIEEMARTN
APVVAGAAGDRLARGLQRLIDHYGLPYVAYNQGSIVHLQSSGVLLLDMRNPVKLLKESKPRKHLMEQLGAAYAAHGIITL
AGSRLYTSMADTDEVIDDALERFDRVFALVEGV
>Mature_753_residues
MLHVPSRRHVVDMCRTLLERGYLKATEGNISVRVPGHDRFAVTPSNYDYAKMRPEDICILDFEGKVVAEAGGSDLPPTVE
SGLHAAVYRERPDVHAVVHTHQPYASALAFLRRPIPALTDEQVRFLGREVAIIDYAPAGTSFLAKNVAKRLGSSANAFII
ANHGILAVGTDPDRAIFNMALLEKVCLAYLLALTTETGRVYTIPSAIREIALTKLKSDQKRIAAQVEQFVPVDRDLVEEP
LPSADAVAERVRTAPGAGPEVAAPGAAPGAADLGYAISDYPDVDAVMRRIKALTGQPVRGLRHDALLDVLAWFDTKCAAS
KELTDRAKARIPGGVQHNLAFNYPFPLAIDRADGAHLTDRDGNVYVDFLQAGGPTILGSNYGPVNEQVAEVIRESGPVTG
LFHEYELKLAESINRYLPHIEMYRSLGSGTEAVMAAVRAARVKTGKHMVIKVGGAYHGWSDSMVYGLRVPGTFRMNAKGI
PFGATAGTRESFPHDVGQLRRKLIENRARGGTAAVIVEPLGPESGTRPAPRDYNARVRELCDEFGALLIFDEVVTGFRVG
MGGAAGYFGVTPDLTVLGKAVAGGYPMAGGVGGSAEVMSVFGSGLDGKNGAHVLVGGTLSANPLSCAAGHFAIEEMARTN
APVVAGAAGDRLARGLQRLIDHYGLPYVAYNQGSIVHLQSSGVLLLDMRNPVKLLKESKPRKHLMEQLGAAYAAHGIITL
AGSRLYTSMADTDEVIDDALERFDRVFALVEGV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=340, Percent_Identity=28.2352941176471, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1786349, Length=436, Percent_Identity=33.4862385321101, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789016, Length=356, Percent_Identity=31.1797752808989, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI145693181, Length=326, Percent_Identity=32.8220858895706, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1787560, Length=292, Percent_Identity=30.4794520547945, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789759, Length=424, Percent_Identity=27.122641509434, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788044, Length=342, Percent_Identity=30.4093567251462, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789164, Length=186, Percent_Identity=31.1827956989247, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1789094, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=341, Percent_Identity=26.9794721407625, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=319, Percent_Identity=27.8996865203762, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=340, Percent_Identity=27.0588235294118, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 80604; Mature: 80604

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHVPSRRHVVDMCRTLLERGYLKATEGNISVRVPGHDRFAVTPSNYDYAKMRPEDICIL
CCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEECCCCCCHHHCCCCCEEEE
DFEGKVVAEAGGSDLPPTVESGLHAAVYRERPDVHAVVHTHQPYASALAFLRRPIPALTD
ECCCEEEEECCCCCCCCHHHHCCEEEHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCH
EQVRFLGREVAIIDYAPAGTSFLAKNVAKRLGSSANAFIIANHGILAVGTDPDRAIFNMA
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCHHHHHHH
LLEKVCLAYLLALTTETGRVYTIPSAIREIALTKLKSDQKRIAAQVEQFVPVDRDLVEEP
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LPSADAVAERVRTAPGAGPEVAAPGAAPGAADLGYAISDYPDVDAVMRRIKALTGQPVRG
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCH
LRHDALLDVLAWFDTKCAASKELTDRAKARIPGGVQHNLAFNYPFPLAIDRADGAHLTDR
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCEEECC
DGNVYVDFLQAGGPTILGSNYGPVNEQVAEVIRESGPVTGLFHEYELKLAESINRYLPHI
CCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHH
EMYRSLGSGTEAVMAAVRAARVKTGKHMVIKVGGAYHGWSDSMVYGLRVPGTFRMNAKGI
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEECCCCC
PFGATAGTRESFPHDVGQLRRKLIENRARGGTAAVIVEPLGPESGTRPAPRDYNARVREL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHH
CDEFGALLIFDEVVTGFRVGMGGAAGYFGVTPDLTVLGKAVAGGYPMAGGVGGSAEVMSV
HHHHCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
FGSGLDGKNGAHVLVGGTLSANPLSCAAGHFAIEEMARTNAPVVAGAAGDRLARGLQRLI
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHH
DHYGLPYVAYNQGSIVHLQSSGVLLLDMRNPVKLLKESKPRKHLMEQLGAAYAAHGIITL
HHCCCCEEEECCCCEEEEECCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
AGSRLYTSMADTDEVIDDALERFDRVFALVEGV
ECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHVPSRRHVVDMCRTLLERGYLKATEGNISVRVPGHDRFAVTPSNYDYAKMRPEDICIL
CCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEECCCCCCHHHCCCCCEEEE
DFEGKVVAEAGGSDLPPTVESGLHAAVYRERPDVHAVVHTHQPYASALAFLRRPIPALTD
ECCCEEEEECCCCCCCCHHHHCCEEEHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCH
EQVRFLGREVAIIDYAPAGTSFLAKNVAKRLGSSANAFIIANHGILAVGTDPDRAIFNMA
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCHHHHHHH
LLEKVCLAYLLALTTETGRVYTIPSAIREIALTKLKSDQKRIAAQVEQFVPVDRDLVEEP
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LPSADAVAERVRTAPGAGPEVAAPGAAPGAADLGYAISDYPDVDAVMRRIKALTGQPVRG
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCH
LRHDALLDVLAWFDTKCAASKELTDRAKARIPGGVQHNLAFNYPFPLAIDRADGAHLTDR
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCEEECC
DGNVYVDFLQAGGPTILGSNYGPVNEQVAEVIRESGPVTGLFHEYELKLAESINRYLPHI
CCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHH
EMYRSLGSGTEAVMAAVRAARVKTGKHMVIKVGGAYHGWSDSMVYGLRVPGTFRMNAKGI
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEECCCCC
PFGATAGTRESFPHDVGQLRRKLIENRARGGTAAVIVEPLGPESGTRPAPRDYNARVREL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHH
CDEFGALLIFDEVVTGFRVGMGGAAGYFGVTPDLTVLGKAVAGGYPMAGGVGGSAEVMSV
HHHHCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
FGSGLDGKNGAHVLVGGTLSANPLSCAAGHFAIEEMARTNAPVVAGAAGDRLARGLQRLI
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHH
DHYGLPYVAYNQGSIVHLQSSGVLLLDMRNPVKLLKESKPRKHLMEQLGAAYAAHGIITL
HHCCCCEEEECCCCEEEEECCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
AGSRLYTSMADTDEVIDDALERFDRVFALVEGV
ECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA