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The map label for this gene is crp [H]

Identifier: 119715876

GI number: 119715876

Start: 1745761

End: 1746564

Strand: Reverse

Name: crp [H]

Synonym: Noca_1641

Alternate gene names: 119715876

Gene position: 1746564-1745761 (Counterclockwise)

Preceding gene: 119715877

Following gene: 119715875

Centisome position: 35.03

GC content: 69.03

Gene sequence:

>804_bases
ATGGGAACCCGACCACCCCACTGCCTGACGATCACGGACCCGGAGGACCTTGCGGGAGGGGCCCGACCCTGGTCCCCCGG
GCGCAGAGAGGACGACGTGGAGATCGAGCGCGCCGCTGCCGGCCCGGACCGGCTCTGGTGCATGTCCGAGGTGGACATCT
TCTGCGACCTCGACGACACGGAGATGGATGCGCTGGCGCAGGCGGCGCCGATGCGGGCCTACGCGACAGGCGCGCTCGTC
TACACCCCACACCAGCCGCTGGAGACCCTGTTCATCCTCAAGAAGGGGCGGATCCGCATCTTCCGGGTCTCCCCCGACGG
ACGCGCACTCACGACCGCGATCATCGATCCCGGCACGATCTTCGGGGAGATGGTCATCGTGGGGCAGCAGATGCACGACA
GCTTCGCCGAGGCGCTCGACGACGTCGTCGTGTGCGTGATGACCAAGGCCGATGTGCGCCGGCTCCTCCTCGGCGACCCG
AGGATCTCAGCGCGGATCTCGGAGACCCTGGGTCGTCGCATCGGTGAGCTGGAGCAGAAGTTCTCCGACGCGGTCTTCAA
GTCCGTCCCCGAGCGGATCGCCGGGGCTCTGGTCACTCTCGCCTCCGCCACCTCGGGCCGACCGCTCGGACGGGGCATCC
AGGTCCGCCTCACCCACGAGCAGCTCGCCGCACTCGCCGCGACCTCGCGCGAGACCACGACCAAGATCCTCGGCGACCTG
GCGGACCAGGGGTTGATCACCCTCGGTCGCGGCCGGATCACCATCTTGAACCGAGAGCGCCTGCGGGTGCTCAGCGGCGA
GTAG

Upstream 100 bases:

>100_bases
CGCACTGACCCCTCGCTGACCCCACGTCCCGTCAGCCGGGTGGCGGGCTCCGCCACCCGGCTGGACGTGGTCCGCCCCAA
GCCCCGACGAGGATGACACG

Downstream 100 bases:

>100_bases
TACTCCGCACGACCGCCGTGGCGCTCGCTCAGGCACCCGACGGGGTGAGGTGATCAATGTCGGTGGGCAGTGAGGCACGC
GACGCTCACGGCACGCCAGG

Product: cyclic nucleotide-binding protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MGTRPPHCLTITDPEDLAGGARPWSPGRREDDVEIERAAAGPDRLWCMSEVDIFCDLDDTEMDALAQAAPMRAYATGALV
YTPHQPLETLFILKKGRIRIFRVSPDGRALTTAIIDPGTIFGEMVIVGQQMHDSFAEALDDVVVCVMTKADVRRLLLGDP
RISARISETLGRRIGELEQKFSDAVFKSVPERIAGALVTLASATSGRPLGRGIQVRLTHEQLAALAATSRETTTKILGDL
ADQGLITLGRGRITILNRERLRVLSGE

Sequences:

>Translated_267_residues
MGTRPPHCLTITDPEDLAGGARPWSPGRREDDVEIERAAAGPDRLWCMSEVDIFCDLDDTEMDALAQAAPMRAYATGALV
YTPHQPLETLFILKKGRIRIFRVSPDGRALTTAIIDPGTIFGEMVIVGQQMHDSFAEALDDVVVCVMTKADVRRLLLGDP
RISARISETLGRRIGELEQKFSDAVFKSVPERIAGALVTLASATSGRPLGRGIQVRLTHEQLAALAATSRETTTKILGDL
ADQGLITLGRGRITILNRERLRVLSGE
>Mature_266_residues
GTRPPHCLTITDPEDLAGGARPWSPGRREDDVEIERAAAGPDRLWCMSEVDIFCDLDDTEMDALAQAAPMRAYATGALVY
TPHQPLETLFILKKGRIRIFRVSPDGRALTTAIIDPGTIFGEMVIVGQQMHDSFAEALDDVVVCVMTKADVRRLLLGDPR
ISARISETLGRRIGELEQKFSDAVFKSVPERIAGALVTLASATSGRPLGRGIQVRLTHEQLAALAATSRETTTKILGDLA
DQGLITLGRGRITILNRERLRVLSGE

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=190, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 29097; Mature: 28966

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTRPPHCLTITDPEDLAGGARPWSPGRREDDVEIERAAAGPDRLWCMSEVDIFCDLDDT
CCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCEEEECCCCC
EMDALAQAAPMRAYATGALVYTPHQPLETLFILKKGRIRIFRVSPDGRALTTAIIDPGTI
HHHHHHHHCCCHHHCCCEEEECCCCCHHHHEEEECCCEEEEEECCCCCEEEEEEECCCHH
FGEMVIVGQQMHDSFAEALDDVVVCVMTKADVRRLLLGDPRISARISETLGRRIGELEQK
HHHHHEECHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FSDAVFKSVPERIAGALVTLASATSGRPLGRGIQVRLTHEQLAALAATSRETTTKILGDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHCCHHHHHHHHHHH
ADQGLITLGRGRITILNRERLRVLSGE
HCCCEEEECCCEEEEEEHHHEEEECCC
>Mature Secondary Structure 
GTRPPHCLTITDPEDLAGGARPWSPGRREDDVEIERAAAGPDRLWCMSEVDIFCDLDDT
CCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCEEEECCCCC
EMDALAQAAPMRAYATGALVYTPHQPLETLFILKKGRIRIFRVSPDGRALTTAIIDPGTI
HHHHHHHHCCCHHHCCCEEEECCCCCHHHHEEEECCCEEEEEECCCCCEEEEEEECCCHH
FGEMVIVGQQMHDSFAEALDDVVVCVMTKADVRRLLLGDPRISARISETLGRRIGELEQK
HHHHHEECHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FSDAVFKSVPERIAGALVTLASATSGRPLGRGIQVRLTHEQLAALAATSRETTTKILGDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHCCHHHHHHHHHHH
ADQGLITLGRGRITILNRERLRVLSGE
HCCCEEEECCCEEEEEEHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]