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The map label for this gene is cysM [H]

Identifier: 119715548

GI number: 119715548

Start: 1385045

End: 1386007

Strand: Direct

Name: cysM [H]

Synonym: Noca_1312

Alternate gene names: 119715548

Gene position: 1385045-1386007 (Clockwise)

Preceding gene: 119715547

Following gene: 119715551

Centisome position: 27.78

GC content: 71.03

Gene sequence:

>963_bases
ATGAGGTACGACAACCTCCTCGCCTCCGTCGGGAACACCCCGCTCGTCGGGTTGCCGCGGCTCTCCGCCCAACTCGCTGG
CCCCGGTGCCGACGTACGGCTCTGGGCGAAGCTGGAGGACCGCAACCCGACGGGCTCGATCAAGGACCGTCCGGCCCTGA
AGATGATCGAGGAGGCCGAGAAGGACGGCACCCTGCGGCCGGGGTGCACCATCCTCGAGCCGACCTCTGGCAACACCGGC
ATCTCGCTGGCGATGGCGGCGAAGCTCAAGGGCTACCGGATCGTCTGCGTGATGCCGGAGAACACCTCCGAGGAGCGCCG
CCAGCTGCTGCGGATGTGGGGGGCCGAGATCGTGTCCTCGCCGGCCGCCGGCGGGTCCAACGAGGCCGTCCGGGTCGCCA
AGCGGATCGCCACCGAGCACCCCGACTGGGTGATGCTCTACCAGTACGGCAACGCCGCCAACGCGCTCGCCCACGAGGAG
GGCACCGGCCCGGAGCTGCTCGCCGACCTGCCGTCGATCACCCACTTCGTCGCGGGGCTCGGGACCACGGGGACGCTGAT
GGGTGTCAGCCGCTTCTTCCGAGCCCACAAGGCGGACGTCCGGATCGTGGCGGCGGAGCCGCGCTACGGCGAGCTCGTCT
ACGGCCTGCGCAACCTCGACGAGGGCTTCGTGCCGGAGCTGTACGACGCGGACCTGATCGACTCGCGCTTCTCGGTCGGC
CCCCGCGACGCCGTACGCCGGGTCCGCGAGCTGCTCGAGCTCGAGGGCATCTTCGCGGGTATCTCGACCGGCGCGATCCT
GCACGCCGCCCTGGGCCAGGCCGCGAAGGCGGTCAAGGCCGGGGAGAGCGCCGACATCGCCTTCGTCGTCGCTGACGGCG
GCTGGAAGTACCTCTCGACCGGTGCCTACGAGGGCACCGTCGACGAGGCCGAGGACCGCCTCGAGGGCCAGCTCTGGGCC
TGA

Upstream 100 bases:

>100_bases
CGCTTCATCGGAGGGCTCGAGGCCGAGCTCGCCGACGGCGACCAGGTCGTGGTGCTCCCGGCGGTGGCCGGGGGATGAGC
TCGAACGGCTCGCACGCCGG

Downstream 100 bases:

>100_bases
GGGGTCGGGGCTCGACCCGGCTTCACGAGGTCCCGTCCAGCGTCGCCGGCTCCGCCCGGACCAGGTCGCCGGCGTCCAGC
TCGCCCTCGGCGAGCGGATC

Product: cysteine synthase

Products: NA

Alternate protein names: OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRYDNLLASVGNTPLVGLPRLSAQLAGPGADVRLWAKLEDRNPTGSIKDRPALKMIEEAEKDGTLRPGCTILEPTSGNTG
ISLAMAAKLKGYRIVCVMPENTSEERRQLLRMWGAEIVSSPAAGGSNEAVRVAKRIATEHPDWVMLYQYGNAANALAHEE
GTGPELLADLPSITHFVAGLGTTGTLMGVSRFFRAHKADVRIVAAEPRYGELVYGLRNLDEGFVPELYDADLIDSRFSVG
PRDAVRRVRELLELEGIFAGISTGAILHAALGQAAKAVKAGESADIAFVVADGGWKYLSTGAYEGTVDEAEDRLEGQLWA

Sequences:

>Translated_320_residues
MRYDNLLASVGNTPLVGLPRLSAQLAGPGADVRLWAKLEDRNPTGSIKDRPALKMIEEAEKDGTLRPGCTILEPTSGNTG
ISLAMAAKLKGYRIVCVMPENTSEERRQLLRMWGAEIVSSPAAGGSNEAVRVAKRIATEHPDWVMLYQYGNAANALAHEE
GTGPELLADLPSITHFVAGLGTTGTLMGVSRFFRAHKADVRIVAAEPRYGELVYGLRNLDEGFVPELYDADLIDSRFSVG
PRDAVRRVRELLELEGIFAGISTGAILHAALGQAAKAVKAGESADIAFVVADGGWKYLSTGAYEGTVDEAEDRLEGQLWA
>Mature_320_residues
MRYDNLLASVGNTPLVGLPRLSAQLAGPGADVRLWAKLEDRNPTGSIKDRPALKMIEEAEKDGTLRPGCTILEPTSGNTG
ISLAMAAKLKGYRIVCVMPENTSEERRQLLRMWGAEIVSSPAAGGSNEAVRVAKRIATEHPDWVMLYQYGNAANALAHEE
GTGPELLADLPSITHFVAGLGTTGTLMGVSRFFRAHKADVRIVAAEPRYGELVYGLRNLDEGFVPELYDADLIDSRFSVG
PRDAVRRVRELLELEGIFAGISTGAILHAALGQAAKAVKAGESADIAFVVADGGWKYLSTGAYEGTVDEAEDRLEGQLWA

Specific function: Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in v

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=35.048231511254, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=35.048231511254, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=35.048231511254, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=42.4749163879599, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788754, Length=325, Percent_Identity=37.8461538461538, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=36.2179487179487, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=35.4838709677419, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566674, Length=283, Percent_Identity=36.7491166077738, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI115535073, Length=328, Percent_Identity=35.0609756097561, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=310, Percent_Identity=35.1612903225806, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=34.9206349206349, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=33.4394904458599, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=220, Percent_Identity=30, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=36.1635220125786, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=32.5227963525836, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=37.1794871794872, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=37.1794871794872, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.65 [H]

Molecular weight: Translated: 34360; Mature: 34360

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDNLLASVGNTPLVGLPRLSAQLAGPGADVRLWAKLEDRNPTGSIKDRPALKMIEEAE
CCHHHHHHHCCCCCEEECCCHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHH
KDGTLRPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSEERRQLLRMWGAEIVSS
HCCCCCCCCEEECCCCCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC
PAAGGSNEAVRVAKRIATEHPDWVMLYQYGNAANALAHEEGTGPELLADLPSITHFVAGL
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GTTGTLMGVSRFFRAHKADVRIVAAEPRYGELVYGLRNLDEGFVPELYDADLIDSRFSVG
CCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHCCHHHHCCCCCC
PRDAVRRVRELLELEGIFAGISTGAILHAALGQAAKAVKAGESADIAFVVADGGWKYLST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEC
GAYEGTVDEAEDRLEGQLWA
CCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MRYDNLLASVGNTPLVGLPRLSAQLAGPGADVRLWAKLEDRNPTGSIKDRPALKMIEEAE
CCHHHHHHHCCCCCEEECCCHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHH
KDGTLRPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSEERRQLLRMWGAEIVSS
HCCCCCCCCEEECCCCCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC
PAAGGSNEAVRVAKRIATEHPDWVMLYQYGNAANALAHEEGTGPELLADLPSITHFVAGL
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GTTGTLMGVSRFFRAHKADVRIVAAEPRYGELVYGLRNLDEGFVPELYDADLIDSRFSVG
CCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHCCHHHHCCCCCC
PRDAVRRVRELLELEGIFAGISTGAILHAALGQAAKAVKAGESADIAFVVADGGWKYLST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEC
GAYEGTVDEAEDRLEGQLWA
CCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]