| Definition | Nocardioides sp. JS614 chromosome, complete genome. |
|---|---|
| Accession | NC_008699 |
| Length | 4,985,871 |
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The map label for this gene is acr1 [H]
Identifier: 119715468
GI number: 119715468
Start: 1308579
End: 1309496
Strand: Direct
Name: acr1 [H]
Synonym: Noca_1232
Alternate gene names: 119715468
Gene position: 1308579-1309496 (Clockwise)
Preceding gene: 119715465
Following gene: 119715471
Centisome position: 26.25
GC content: 73.97
Gene sequence:
>918_bases GTGTCAACGCCCGCGCGCCTCGTGCGTCCGGCTCCGCTACGGTCCTGGCCCATGGGACTGCTGCTCGCCACGCCGCGGGC GCGCGCCGCCCGGGCGCTGCGCCGACTCGTCCACGACCCGGCCAGCCCGCTCGCCGGGCGCACCGTGCTGGTCACCGGGG CGTCCTCCGGGATCGGGGAGGCGACCGCCCGCGAGGTGGCCCGGGCCGGAGCGACCGTCCTCCTCGTGGCGCGCCGCGCC GAGGAGCTCGAGCGGGTCCGGCAGGAGATCGAGGAGGCCGGCGGCCGGGCCTCGGCGTACCCCTGCGACCTGACCGACGG CGACGCCGTCGACGCGCTGGTCGCGCAGGTGCTGGCCGAGCACGGCGTCGTCGACTACCTGGTCAACAACGCCGGCCGGT CGATCCGGCGGTCACTGGACCTCACCCAGGACCGGTTCCACGACTTCGAGCGCACGATGGCGATCAACTACTTCGGACCC GTGCGCCTCACGATGGGCCTCCTGCCGGCGATGCGCGAGCAGGGCTTCGGACACGTCGTCAACGTGCTCAGCTGGGGCGT GCAGATGAAGGCACCGAAGTTCAGCGCCTACCTCGCCTCGAAGACCGCGCTCGACACGTGGAGCCGGATCGCGGGTCGGG AGACGTACGGCGACGGGGTCACCTTCACCAACATCCGGTTCTCGCTGGTGCGTACCGCGATGTCCGCGCCGACCGAGGCG TACGCCGGGCGCGGCGCCAGCCCCGAGCAGGCCGCCGCGCGGGTGCTGCGCGCGCTGGAGGACCGGCCGGTGACGCTGAA CACCCGCGCCGGGGACGTGGGCGAGCTGCTCAACATCCTCGCGCCCCGCCTCAGCGACTGGCTCTACCACCGCTTCGACG CGGTGTTCCCCGACTCCAAGGCCGCCCGCGGCGACTGA
Upstream 100 bases:
>100_bases CAGGCCCACGCGGGAGGCCAGGTCGGCCGCCTCGTCGAGGATCGCGGCACGGGTCTCGGTGCCCTTGCTCATGACCCAAG AAAAGCACGACCGTTCGGAC
Downstream 100 bases:
>100_bases CGCGACTGCTGTAACGCCGTGTTACCCCTTCCTCCCACCGTGCTGCAGCACGGTCGGTAGGACCGGTAACCGGGCGTTAC AGCAAGAAGGGGGCCGGGCG
Product: short-chain dehydrogenase/reductase SDR
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: NA
Number of amino acids: Translated: 305; Mature: 304
Protein sequence:
>305_residues MSTPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGEATAREVARAGATVLLVARRA EELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAEHGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGP VRLTMGLLPAMREQGFGHVVNVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEA YAGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSKAARGD
Sequences:
>Translated_305_residues MSTPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGEATAREVARAGATVLLVARRA EELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAEHGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGP VRLTMGLLPAMREQGFGHVVNVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEA YAGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSKAARGD >Mature_304_residues STPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGEATAREVARAGATVLLVARRAE ELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAEHGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGPV RLTMGLLPAMREQGFGHVVNVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEAY AGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSKAARGD
Specific function: Catalyzes the NADPH-dependent reduction of long chain acyl-CoA to the corresponding aldehyde [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI7706318, Length=170, Percent_Identity=40, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI20149619, Length=256, Percent_Identity=34.765625, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI32455239, Length=223, Percent_Identity=32.7354260089686, Blast_Score=90, Evalue=3e-18, Organism=Homo sapiens, GI5031765, Length=223, Percent_Identity=32.7354260089686, Blast_Score=90, Evalue=3e-18, Organism=Homo sapiens, GI4503817, Length=174, Percent_Identity=36.2068965517241, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI142976729, Length=261, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI32483357, Length=195, Percent_Identity=29.2307692307692, Blast_Score=83, Evalue=4e-16, Organism=Homo sapiens, GI210032110, Length=259, Percent_Identity=28.957528957529, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI126723191, Length=164, Percent_Identity=31.0975609756098, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI225579078, Length=228, Percent_Identity=29.8245614035088, Blast_Score=75, Evalue=9e-14, Organism=Homo sapiens, GI40254986, Length=149, Percent_Identity=32.2147651006711, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI7705855, Length=257, Percent_Identity=25.6809338521401, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI157739938, Length=170, Percent_Identity=30, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI166795268, Length=227, Percent_Identity=30.8370044052863, Blast_Score=73, Evalue=4e-13, Organism=Homo sapiens, GI40807363, Length=204, Percent_Identity=29.9019607843137, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI226371731, Length=198, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=30.4812834224599, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI5031737, Length=182, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI209862901, Length=204, Percent_Identity=30.3921568627451, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI19923983, Length=204, Percent_Identity=30.3921568627451, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI109715829, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=3e-11, Organism=Homo sapiens, GI7705925, Length=233, Percent_Identity=28.755364806867, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=31.9838056680162, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1787905, Length=147, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1786701, Length=202, Percent_Identity=32.6732673267327, Blast_Score=76, Evalue=3e-15, Organism=Escherichia coli, GI1790717, Length=166, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.6703296703297, Blast_Score=73, Evalue=3e-14, Organism=Escherichia coli, GI1789378, Length=196, Percent_Identity=29.5918367346939, Blast_Score=67, Evalue=2e-12, Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=27.8947368421053, Blast_Score=65, Evalue=5e-12, Organism=Escherichia coli, GI2367175, Length=241, Percent_Identity=28.6307053941909, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI87082160, Length=235, Percent_Identity=26.8085106382979, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17559104, Length=250, Percent_Identity=28.4, Blast_Score=88, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17565030, Length=209, Percent_Identity=33.0143540669856, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562906, Length=257, Percent_Identity=31.5175097276265, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17562904, Length=208, Percent_Identity=31.25, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17551412, Length=198, Percent_Identity=30.8080808080808, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17563726, Length=248, Percent_Identity=26.6129032258064, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI71997402, Length=301, Percent_Identity=27.5747508305648, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538486, Length=211, Percent_Identity=30.3317535545024, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538480, Length=204, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17560150, Length=254, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI72000259, Length=249, Percent_Identity=28.9156626506024, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17560332, Length=219, Percent_Identity=29.2237442922374, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17562990, Length=255, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=30.8880308880309, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17564282, Length=162, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17562908, Length=211, Percent_Identity=33.175355450237, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17544670, Length=258, Percent_Identity=29.4573643410853, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=29.4339622641509, Blast_Score=79, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17508895, Length=165, Percent_Identity=29.6969696969697, Blast_Score=76, Evalue=3e-14, Organism=Caenorhabditis elegans, GI193203117, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI193203115, Length=156, Percent_Identity=32.0512820512821, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI71982365, Length=148, Percent_Identity=33.1081081081081, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17558006, Length=153, Percent_Identity=30.0653594771242, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17570069, Length=170, Percent_Identity=33.5294117647059, Blast_Score=71, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=26.9076305220884, Blast_Score=67, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25152911, Length=198, Percent_Identity=32.3232323232323, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17538182, Length=199, Percent_Identity=32.1608040201005, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI32565532, Length=132, Percent_Identity=32.5757575757576, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI72001364, Length=127, Percent_Identity=33.8582677165354, Blast_Score=65, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=30.5, Blast_Score=81, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6322227, Length=214, Percent_Identity=29.4392523364486, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI21358495, Length=262, Percent_Identity=31.6793893129771, Blast_Score=127, Evalue=1e-29, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=34.5098039215686, Blast_Score=97, Evalue=2e-20, Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=31.0483870967742, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=31.7460317460317, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI21357673, Length=166, Percent_Identity=33.1325301204819, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI116007236, Length=197, Percent_Identity=32.994923857868, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=32.4742268041237, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI24644339, Length=178, Percent_Identity=32.5842696629214, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI116007238, Length=134, Percent_Identity=38.0597014925373, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI24641232, Length=230, Percent_Identity=30, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI28571387, Length=233, Percent_Identity=33.0472103004292, Blast_Score=73, Evalue=3e-13, Organism=Drosophila melanogaster, GI24640492, Length=165, Percent_Identity=27.8787878787879, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24647946, Length=145, Percent_Identity=30.3448275862069, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI45553409, Length=143, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24647948, Length=143, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24639444, Length=197, Percent_Identity=31.4720812182741, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI281364892, Length=162, Percent_Identity=28.3950617283951, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI161076371, Length=116, Percent_Identity=33.6206896551724, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24580925, Length=177, Percent_Identity=34.4632768361582, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI21356301, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24586328, Length=141, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24640442, Length=195, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=4e-11, Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI116007234, Length=87, Percent_Identity=42.5287356321839, Blast_Score=65, Evalue=7e-11, Organism=Drosophila melanogaster, GI116007232, Length=87, Percent_Identity=42.5287356321839, Blast_Score=65, Evalue=8e-11, Organism=Drosophila melanogaster, GI24663911, Length=191, Percent_Identity=32.4607329842932, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 33105; Mature: 32974
Theoretical pI: Translated: 10.06; Mature: 10.06
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGE CCCCHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCH ATAREVARAGATVLLVARRAEELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAE HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH HGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGPVRLTMGLLPAMREQGFGHVV CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCHHHHH NVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEA HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCHHH YAGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSK HCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC AARGD CCCCC >Mature Secondary Structure STPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGE CCCHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCH ATAREVARAGATVLLVARRAEELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAE HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH HGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGPVRLTMGLLPAMREQGFGHVV CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCHHHHH NVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEA HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCHHH YAGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSK HCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC AARGD CCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA