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The map label for this gene is gutB [H]

Identifier: 119715403

GI number: 119715403

Start: 1238590

End: 1239645

Strand: Direct

Name: gutB [H]

Synonym: Noca_1166

Alternate gene names: 119715403

Gene position: 1238590-1239645 (Clockwise)

Preceding gene: 119715399

Following gene: 119715404

Centisome position: 24.84

GC content: 68.66

Gene sequence:

>1056_bases
ATGACGCAGATCATGCAGGCCCTGGTGGTGCGCGAGCCCAATGTGCTCGAGATCGCCGAGGTGCCTGTGCCCGAGCCCGG
TCGCAACGAGGTCTTGGCGCGAGTCCGATCCGTCTCGATCTGCGGCACCGACGCCCACCTCATCAACGGTGACTACCCCG
GGTTCTGGCCGCCGCAGTTCCCCTTCACCCCCGGCCACGAATGGGCGGGTGACGTCGTGGCCCTCGGTGAGGGTGCGGAC
ACCTTCGGCTGGCGGGTCGGCGACCGGGTCGCGGGCACGAGCCACAGTGCTTGCGGCGCCTGCCAGAAGTGCGTCGAAGG
CCAGTACAACCTGTGTGAGAACTACGGCAGGCCGGCGCTCCATGCTCAGTACGGACACAACGCGCAGGGGGTCAACGCCA
CCTATGCCGTCCACAACGTCAAGTCGATCTTCCGGCTGCCCGATGAGGTGAGCTTCGATGTCGGTGCCCTGGCTGACCCG
GCCAGCATCGCCCTGCACGTAGCACGTCGCGGCAACATCAAGCCGGGGGACACCGTTGCGGTGACCGGTGCCGGCGCGAT
CGGCCTCCTCGCGGCTGACGCCGCACTGATCGATGGGGCCGCGCGGGTGATCGTGGTGGGGCGCGGCCACCGTCTGGAGC
GGGCTGCTGCGCTGGGGTTCGAGACCGTCGACACGCGCACAGGCGACCCGGTCGCCGAGGTGCGTGGACTGACGAGTGGC
CTCGGCGCCGACGTGGTCCTGGAATGTGCGGGCGTCCCCGAGACCCTGATCTGGGGGATGGCGATGCTGCGCCGCGGCGG
TCGCTGCGCGATGGTCGGCATCCCGACCGAGGACGTCAGCCTGAAGTGCCAGCCCCTCGTGCTCGATGAGCTGGAGCTGG
TCGGCTCACGCGCCTCTGCCGGTGAGATGCGCCGCGTCCTGCCCTTCATCGCCAACGGGAGGATGCGGGCCGAGGAGCTC
ATCACCCACCACTTCCCGCTCTCGGAGTACGACAAGGCGCTGGCCACGTTCAACGACCGTGCCAGCGGTGCGATCAAGAT
CATCGTCAACCCCTAG

Upstream 100 bases:

>100_bases
TGCGCCTCGGCATGACGGCGAGATCTAGTGGCTTGACTCACACTCCGAGCACCCTTACCCTCGATTATCGATAAAGGTCT
GAACCCTCGCAGGAGCGATG

Downstream 100 bases:

>100_bases
ACCCACGGTCACGCGAGCTGAGAGGAGGGTTGGTGCGCTACTACCGTCCAGCGACCACCGCACAGGCGGTGGCCGCTCTA
GCCGGCCAGCCGCACGCCTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQFPFTPGHEWAGDVVALGEGAD
TFGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPALHAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADP
ASIALHVARRGNIKPGDTVAVTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSG
LGADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASAGEMRRVLPFIANGRMRAEEL
ITHHFPLSEYDKALATFNDRASGAIKIIVNP

Sequences:

>Translated_351_residues
MTQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQFPFTPGHEWAGDVVALGEGAD
TFGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPALHAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADP
ASIALHVARRGNIKPGDTVAVTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSG
LGADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASAGEMRRVLPFIANGRMRAEEL
ITHHFPLSEYDKALATFNDRASGAIKIIVNP
>Mature_350_residues
TQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQFPFTPGHEWAGDVVALGEGADT
FGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPALHAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADPA
SIALHVARRGNIKPGDTVAVTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSGL
GADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASAGEMRRVLPFIANGRMRAEELI
THHFPLSEYDKALATFNDRASGAIKIIVNP

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=349, Percent_Identity=30.3724928366762, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI71565152, Length=358, Percent_Identity=26.8156424581006, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501929, Length=349, Percent_Identity=26.647564469914, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=24.6537396121884, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=24.6537396121884, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=26.4788732394366, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501933, Length=348, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790045, Length=335, Percent_Identity=32.8358208955224, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=30.6590257879656, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=28.448275862069, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI226510992, Length=327, Percent_Identity=31.1926605504587, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082125, Length=362, Percent_Identity=30.6629834254144, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=26.2247838616715, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=25.8720930232558, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=27.6807980049875, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790718, Length=340, Percent_Identity=23.8235294117647, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=28.0112044817927, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=27.1293375394322, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786518, Length=306, Percent_Identity=28.1045751633987, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=358, Percent_Identity=29.3296089385475, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562878, Length=359, Percent_Identity=30.3621169916435, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=314, Percent_Identity=30.5732484076433, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=312, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=303, Percent_Identity=25.0825082508251, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=352, Percent_Identity=28.9772727272727, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=24.6575342465753, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=29.0030211480363, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=327, Percent_Identity=29.6636085626911, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=384, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=367, Percent_Identity=27.5204359673025, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=314, Percent_Identity=29.6178343949045, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=311, Percent_Identity=28.6173633440514, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=30.2941176470588, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17737897, Length=340, Percent_Identity=30.8823529411765, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45550770, Length=354, Percent_Identity=28.5310734463277, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221457811, Length=354, Percent_Identity=28.5310734463277, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45551930, Length=354, Percent_Identity=28.5310734463277, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=24.9299719887955, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 37199; Mature: 37068

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQF
CHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHEEEECCCCEEECCCCCCCCCCCC
PFTPGHEWAGDVVALGEGADTFGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPAL
CCCCCCCCCCCEEEECCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCE
HAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADPASIALHVARRGNIKPGDTVA
EECCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEHHHCCCCCCCCEEE
VTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSG
EECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCEECCCCCCCHHHHHHHHHCC
LGADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASA
CCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCEEHHHHHHHCCCCCH
GEMRRVLPFIANGRMRAEELITHHFPLSEYDKALATFNDRASGAIKIIVNP
HHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
TQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQF
HHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHEEEECCCCEEECCCCCCCCCCCC
PFTPGHEWAGDVVALGEGADTFGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPAL
CCCCCCCCCCCEEEECCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCE
HAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADPASIALHVARRGNIKPGDTVA
EECCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEHHHCCCCCCCCEEE
VTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSG
EECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCEECCCCCCCHHHHHHHHHCC
LGADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASA
CCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCEEHHHHHHHCCCCCH
GEMRRVLPFIANGRMRAEELITHHFPLSEYDKALATFNDRASGAIKIIVNP
HHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10086842; 11058132 [H]