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The map label for this gene is mutT2 [H]

Identifier: 119715392

GI number: 119715392

Start: 1229066

End: 1229440

Strand: Direct

Name: mutT2 [H]

Synonym: Noca_1154

Alternate gene names: 119715392

Gene position: 1229066-1229440 (Clockwise)

Preceding gene: 119715391

Following gene: 119715393

Centisome position: 24.65

GC content: 76.53

Gene sequence:

>375_bases
GTGGTGGGTGCGGCCATCCTGCGCGACGGGCGGGTGCTGGCGGCGCGCCGTACGTTCCCCGCCGAGGCGGCCGGGCGCTG
GGAGCTCCCCGGCGGCAAGGTCGAGCCGGGGGAGACCCCGGAGGACGCGCTGGTCCGCGAGGTCGCCGAGGAGCTCGGCT
GCACCATCGAGCTGACCGGCTGGCTCCCCGAGGAGGTCGCCATCGGCGACCGACACGTGCTCCGGGTCGCGCTCGCGCGC
CTGGTGGCCGACGAGCCGACGCCACACGAGCACGACCGGGTCCGCTGGCTGGGCGCCGACGAGCTCGAGGACGTCGACTG
GCTCGACCCGGACCGGCCGTTCCTGCTCGCCGTACGGGCCGCGCTCCTGGGATGA

Upstream 100 bases:

>100_bases
ACCCGCAGCGACTGGGCGACCTGGTCGGACACCTGACCGGTGCCGAGCTGGACGAGGTCGATAGGTCCCTGCGCATCGTG
CTGGGCCTCGAGTGAGCGCA

Downstream 100 bases:

>100_bases
TCGGCGGGTGCGCGGGATCTTCTTCGACGAGGACGACGCCCGAGCCGTGGTCGCCCGCCTGATCGCGCTCGGGTACGACG
CGCACGCCGAGCGGGACCGG

Product: NUDIX hydrolase

Products: CMP; diphosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTGWLPEEVAIGDRHVLRVALAR
LVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRAALLG

Sequences:

>Translated_124_residues
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTGWLPEEVAIGDRHVLRVALAR
LVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRAALLG
>Mature_124_residues
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTGWLPEEVAIGDRHVLRVALAR
LVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRAALLG

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 13618; Mature: 13618

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTG
CCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECC
WLPEEVAIGDRHVLRVALARLVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRA
CCCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
ALLG
HHCC
>Mature Secondary Structure
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTG
CCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECC
WLPEEVAIGDRHVLRVALARLVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRA
CCCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
ALLG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]