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The map label for this gene is nuoH

Identifier: 119714791

GI number: 119714791

Start: 558711

End: 560060

Strand: Direct

Name: nuoH

Synonym: Noca_0527

Alternate gene names: 119714791

Gene position: 558711-560060 (Clockwise)

Preceding gene: 119714790

Following gene: 119714792

Centisome position: 11.21

GC content: 68.3

Gene sequence:

>1350_bases
ATGAACACCCTGACCGCACCGCTCCCGATGGCGACCGACGCCCTCTCGCAGTTCGGGCACGACGCGTGGTGGGTGATCGG
GCTCAAGGCCGTGCTGATCCTGGTCGTGCTCCTGCTGCTGACGCTGTTCAACATCTGGTTCGAGCGGCGCGTGGTCGGCC
GGATGCAGCACCGGCCCGGGCCCAACGTCAACGGACCCTTCGGGCTCCTGCAGTCGCTGGCCGACGCCCTCAAGCTGATC
TTCAAGGAGGGCATCATCCCGAAGGCGGCCGACAAGGCCGTCTACCTGATCGCCCCGGTGATCGCCGTGATCCCGTCCTT
CATCACGTTCTCGGTGATCCCGTTCGGGCCCGAGGTGACGATCCCGTTCACCGACACCCGCACGCCGCTCCAGCTCACCG
ACATGCCGGTCGCCGTGCTGTTCGTCATGGCGATCGCCTCGATCGGCATCTACGGCATCGTGCTCGGGGGATGGTCGAGC
GGTTCGACGTACTCCCTGCTCGGCGGCCTGCGCTCGAGCGCCCAGATGATCTCCTACGAGGTCGCGATGGGCCTCGCGCT
GGTCGCGGTGTTCCTGTACGCCGGCTCGATGTCGACCTCGGAGATCGTCGCGGCCCAGGACAACCTCTGGTACGGGCTGA
TCCTGGTGCCCTCGTTCGTGATCTACCTGATCGCGATGGTCGGCGAGACCAACCGCGCGCCGTTCGACCTCCCCGAGGCC
GAGGGTGAGCTGGTGGGCGGGTTCCACACCGAGTACTCCTCGATGACCTTCGCCCTGTTCTTCCTGGCCGAGTACATCAA
CATGGCGACCGTGTCCGCCGTCGCGACCACCCTGTTCCTCGGCGGCTGGCACGCGCCGTTCTGGCTCGACCACGCCTGGG
CGGGCGCGAACGAGGGCTACTGGCCACTGCTGTGGTTCCTCGGCAAGGTCTTGTTCTTCGTCTTCATCTTCATCTGGCTC
CGCGGCACCCTGCCCCGCCTGCGCTACGACCAGTTCATGGCGTTCGGGTGGAAGCGGCTGATCCCGGTCGCGCTGGTCTG
GATCGTCGCGGTCGCGACGATCCGGTCGATCTCGCTCGACGGCGGCGTCGACCGGCGCTACCTGCTGATCGGCATCGGCG
CCCTCGCCGTGGTCTTCCTGGTCCTGTTCTTCATCGGCGGGGCCGCCGAGGAGCAGCCGACCACGGTGCCGGAGGCCGCG
CCTGCCGGCGGGTACCCCGTACCCCCGATGCCGGCCGGCGGTCCGGTCCGCGGGGCCGCGGTCCCGCTCACGTTCGACCG
CAGTTCACCCATCGCCTCGTCGATGCCACAGCCCAGCGCTGCCACCCGCAGCGCGGGGGAGGAGATCTGA

Upstream 100 bases:

>100_bases
ACGGGGTGGTGTGGGTGCCTGCGAACTCCTTCGGCAACGGGGTGCTGGCCGACCTGGCCTCGCCCGGCAGTCGCGTGACC
GTCGCGAAGGGGGCCGACGC

Downstream 100 bases:

>100_bases
TGGCTGGCAGTCCCGAGCCCAAGAGCATGCGCGAGCAGTTCTGGGACCCGATCGCCGGGTTCGGCGTCACCTTCCGGACC
ATGTTCAAGAAGGTCGTCAC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNTLTAPLPMATDALSQFGHDAWWVIGLKAVLILVVLLLLTLFNIWFERRVVGRMQHRPGPNVNGPFGLLQSLADALKLI
FKEGIIPKAADKAVYLIAPVIAVIPSFITFSVIPFGPEVTIPFTDTRTPLQLTDMPVAVLFVMAIASIGIYGIVLGGWSS
GSTYSLLGGLRSSAQMISYEVAMGLALVAVFLYAGSMSTSEIVAAQDNLWYGLILVPSFVIYLIAMVGETNRAPFDLPEA
EGELVGGFHTEYSSMTFALFFLAEYINMATVSAVATTLFLGGWHAPFWLDHAWAGANEGYWPLLWFLGKVLFFVFIFIWL
RGTLPRLRYDQFMAFGWKRLIPVALVWIVAVATIRSISLDGGVDRRYLLIGIGALAVVFLVLFFIGGAAEEQPTTVPEAA
PAGGYPVPPMPAGGPVRGAAVPLTFDRSSPIASSMPQPSAATRSAGEEI

Sequences:

>Translated_449_residues
MNTLTAPLPMATDALSQFGHDAWWVIGLKAVLILVVLLLLTLFNIWFERRVVGRMQHRPGPNVNGPFGLLQSLADALKLI
FKEGIIPKAADKAVYLIAPVIAVIPSFITFSVIPFGPEVTIPFTDTRTPLQLTDMPVAVLFVMAIASIGIYGIVLGGWSS
GSTYSLLGGLRSSAQMISYEVAMGLALVAVFLYAGSMSTSEIVAAQDNLWYGLILVPSFVIYLIAMVGETNRAPFDLPEA
EGELVGGFHTEYSSMTFALFFLAEYINMATVSAVATTLFLGGWHAPFWLDHAWAGANEGYWPLLWFLGKVLFFVFIFIWL
RGTLPRLRYDQFMAFGWKRLIPVALVWIVAVATIRSISLDGGVDRRYLLIGIGALAVVFLVLFFIGGAAEEQPTTVPEAA
PAGGYPVPPMPAGGPVRGAAVPLTFDRSSPIASSMPQPSAATRSAGEEI
>Mature_449_residues
MNTLTAPLPMATDALSQFGHDAWWVIGLKAVLILVVLLLLTLFNIWFERRVVGRMQHRPGPNVNGPFGLLQSLADALKLI
FKEGIIPKAADKAVYLIAPVIAVIPSFITFSVIPFGPEVTIPFTDTRTPLQLTDMPVAVLFVMAIASIGIYGIVLGGWSS
GSTYSLLGGLRSSAQMISYEVAMGLALVAVFLYAGSMSTSEIVAAQDNLWYGLILVPSFVIYLIAMVGETNRAPFDLPEA
EGELVGGFHTEYSSMTFALFFLAEYINMATVSAVATTLFLGGWHAPFWLDHAWAGANEGYWPLLWFLGKVLFFVFIFIWL
RGTLPRLRYDQFMAFGWKRLIPVALVWIVAVATIRSISLDGGVDRRYLLIGIGALAVVFLVLFFIGGAAEEQPTTVPEAA
PAGGYPVPPMPAGGPVRGAAVPLTFDRSSPIASSMPQPSAATRSAGEEI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=314, Percent_Identity=38.5350318471338, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=40.3669724770642, Blast_Score=246, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_NOCSJ (A1SE34)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921756.1
- ProteinModelPortal:   A1SE34
- STRING:   A1SE34
- GeneID:   4596447
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0527
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- PhylomeDB:   A1SE34
- ProtClustDB:   PRK06076
- BioCyc:   NSP35761:NOCA_0527-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 48539; Mature: 48539

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2; PS00456 NA_SOLUT_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x140e9194)-; HASH(0x143d7344)-; HASH(0x157f0cbc)-; HASH(0x1460c15c)-; HASH(0x1406b924)-; HASH(0x152e4398)-; HASH(0x10dff7bc)-; HASH(0x15836fbc)-; HASH(0x15bd5390)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLTAPLPMATDALSQFGHDAWWVIGLKAVLILVVLLLLTLFNIWFERRVVGRMQHRPG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNVNGPFGLLQSLADALKLIFKEGIIPKAADKAVYLIAPVIAVIPSFITFSVIPFGPEVT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCEEE
IPFTDTRTPLQLTDMPVAVLFVMAIASIGIYGIVLGGWSSGSTYSLLGGLRSSAQMISYE
EEECCCCCCCEECCCHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VAMGLALVAVFLYAGSMSTSEIVAAQDNLWYGLILVPSFVIYLIAMVGETNRAPFDLPEA
HHHHHHHHHHHHHHCCCCCHHHEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EGELVGGFHTEYSSMTFALFFLAEYINMATVSAVATTLFLGGWHAPFWLDHAWAGANEGY
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
WPLLWFLGKVLFFVFIFIWLRGTLPRLRYDQFMAFGWKRLIPVALVWIVAVATIRSISLD
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGVDRRYLLIGIGALAVVFLVLFFIGGAAEEQPTTVPEAAPAGGYPVPPMPAGGPVRGAA
CCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VPLTFDRSSPIASSMPQPSAATRSAGEEI
EEEEECCCCCCHHCCCCCCHHHCCCCCCH
>Mature Secondary Structure
MNTLTAPLPMATDALSQFGHDAWWVIGLKAVLILVVLLLLTLFNIWFERRVVGRMQHRPG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNVNGPFGLLQSLADALKLIFKEGIIPKAADKAVYLIAPVIAVIPSFITFSVIPFGPEVT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCEEE
IPFTDTRTPLQLTDMPVAVLFVMAIASIGIYGIVLGGWSSGSTYSLLGGLRSSAQMISYE
EEECCCCCCCEECCCHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VAMGLALVAVFLYAGSMSTSEIVAAQDNLWYGLILVPSFVIYLIAMVGETNRAPFDLPEA
HHHHHHHHHHHHHHCCCCCHHHEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EGELVGGFHTEYSSMTFALFFLAEYINMATVSAVATTLFLGGWHAPFWLDHAWAGANEGY
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
WPLLWFLGKVLFFVFIFIWLRGTLPRLRYDQFMAFGWKRLIPVALVWIVAVATIRSISLD
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGVDRRYLLIGIGALAVVFLVLFFIGGAAEEQPTTVPEAAPAGGYPVPPMPAGGPVRGAA
CCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VPLTFDRSSPIASSMPQPSAATRSAGEEI
EEEEECCCCCCHHCCCCCCHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA