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The map label for this gene is ubiE

Identifier: 119714783

GI number: 119714783

Start: 550120

End: 550809

Strand: Direct

Name: ubiE

Synonym: Noca_0519

Alternate gene names: 119714783

Gene position: 550120-550809 (Clockwise)

Preceding gene: 119714781

Following gene: 119714784

Centisome position: 11.03

GC content: 73.33

Gene sequence:

>690_bases
GTGGTCCGTGCCGAGCTCGACAAGCAGCCCTCCGACGTCCGTCGCATGTTCGATGCGGTCGCCCGGCGCTACGACGTCAC
CAACGACGTGCTCTCGATGGGGCAGGACCGCCGCTGGCGCAGGGCCGTCATCGCGGCCGTCGACCCGCAGCCCGGCGAGC
GGGTCCTCGACCTCGCGGCGGGCACCGGTACGTCGAGCCAGCCGTTCGCCGACCGCGGCGCGAGCGTGGTGCCGTGCGAC
TTCTCGCTCGGCATGCTGCGGGTCGGCAAGTCGGCGCTGCCGCACCTGCCGTTCACGGCCGGTGACGGCACCCGGCTGCC
GTTCGCCGACGCGACCTTCGACGCGGTCACCATCTCCTTCGGGCTGCGCAACATCGTCGACCCGCTTTCCGGCCTGCGCG
AGCTGCACCGGGTGACCCGGCCCGGTGGCCGGCTGGTCGTGTGCGAGTTCAGCCATCCGACGTTCGCGCCGTTCCGCACC
GTCTACCTCGAGTACCTGATGCGGGCCCTGCCGTCGATCGCCCGCGCCGTCTCCTCCGCACCGGACGCCTACGTCTACCT
CGCCGAGTCGATCCGTGCCTGGCCCGACCAGGAGGGCCTGGCCGCGATGGTCGCCGAGGCGGGCTGGCGGGCTCCGGCCT
GGCGCAACCTCTCCGGCGGCATCGTCGCCCTGCACCGCGCCACCCGGTAG

Upstream 100 bases:

>100_bases
CGCTCGGTTGCACCCGCGCGGCGAGTTCCCGCGGTCGTGACCAAGCTGTGACCCGGGACGCGGAGGGCGGGGCGAGCCGG
CCGGGTCGTAGTCTCTGCCC

Downstream 100 bases:

>100_bases
GTCCGACGGCTCGGCCGACGCCCTCGGGGGTGCTCCGGCGTCCCGTCTCGGGACCCGTCCGGGACCCGTCTCGGGGCCCG
TTTCAGGGCCCGGTGAGAGC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAAGTGTSSQPFADRGASVVPCD
FSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISFGLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRT
VYLEYLMRALPSIARAVSSAPDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR

Sequences:

>Translated_229_residues
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAAGTGTSSQPFADRGASVVPCD
FSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISFGLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRT
VYLEYLMRALPSIARAVSSAPDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR
>Mature_229_residues
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAAGTGTSSQPFADRGASVVPCD
FSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISFGLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRT
VYLEYLMRALPSIARAVSSAPDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=31.6981132075472, Blast_Score=148, Evalue=4e-36,
Organism=Escherichia coli, GI48994983, Length=232, Percent_Identity=41.3793103448276, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17557039, Length=232, Percent_Identity=30.1724137931034, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323526, Length=236, Percent_Identity=31.3559322033898, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24641702, Length=240, Percent_Identity=34.1666666666667, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_NOCSJ (A1SE26)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921748.1
- ProteinModelPortal:   A1SE26
- SMR:   A1SE26
- STRING:   A1SE26
- GeneID:   4596439
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0519
- eggNOG:   COG2226
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- PhylomeDB:   A1SE26
- ProtClustDB:   PRK00216
- BioCyc:   NSP35761:NOCA_0519-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 25050; Mature: 25050

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAA
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHEEEECCCCCCHHHHHHHC
GTGTSSQPFADRGASVVPCDFSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISF
CCCCCCCCHHHCCCEEEECCCCHHHHHHCHHHCCCCCEECCCCCCCCCCCCCHHHHHHHH
GLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRTVYLEYLMRALPSIARAVSSA
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR
CCCEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAA
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHEEEECCCCCCHHHHHHHC
GTGTSSQPFADRGASVVPCDFSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISF
CCCCCCCCHHHCCCEEEECCCCHHHHHHCHHHCCCCCEECCCCCCCCCCCCCHHHHHHHH
GLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRTVYLEYLMRALPSIARAVSSA
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR
CCCEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA