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The map label for this gene is hemL

Identifier: 119714763

GI number: 119714763

Start: 530333

End: 531670

Strand: Direct

Name: hemL

Synonym: Noca_0499

Alternate gene names: 119714763

Gene position: 530333-531670 (Clockwise)

Preceding gene: 119714761

Following gene: 119714764

Centisome position: 10.64

GC content: 74.74

Gene sequence:

>1338_bases
GTGACCGCCGGAGCAACCCTGCCCACCGCCGCCTCCGCGGCGCTCTTCGAGCGCGCCCGGGCGGTGACGCCGGGCGGCGT
GAACTCCCCGGTCCGCGCGTTCAACGCGGTCGGTGGCACGCCCCGCTTCATCCGCTCGGCGCGCGGCGCATGGCTGACCG
ACGCCGACGGCAACGAGTACGTCGACCTGATCTGCTCCTGGGGCCCGATGCTGCTCGGCCACGCCCACCCCGAGGTGCAG
GCGGCGGTGTCCGCCGCGGTCGCCCGCGGCACGTCGTACGGCGCTCCCACCGAGCCGGAGGTCGAGCTGGCCGAGGAGAT
CGCGGCCCGGGCGCCGGTCGAGCGGGTCCGGTTCGTGTCCTCGGGCACCGAGGCCACCATGTCGGCGATCCGGCTGGCCC
GCGGGTTCACCGGCCGCGACGTCGTGGTCAAGTTCGCCGGCTGCTACCACGGGCACGTCGACTCGCTGCTCGCCTCGGCC
GGTTCCGGCCTCGCGACGTTCGCGGTGCCAGGCACCCCCGGCGTCCCGGAGTCGTCGACGGCCCTGACCCTGGTGCTGCC
GTACAACGACCGGGCCGCGGTGGAGAAGGCGTTCGCCGAGCACGGCGACCGGATCGCCTGCCTGATCACCGAGGCTGCCC
CCGGCAACATGGGCGTCGTCCCTCCGGACGCCGACGGGTCGGGAGGAGGCTTCAACGGCTTCCTGGCCGAGACCTGCGCC
CGGCACGGCGCACTGTTCGTCAGCGACGAGGTGATGACCGGGTTCCGGGCCTCCCGGCAGGGCCAGTGGGGACTGGACGG
CGCGGTCGAGGGCTGGCGCCCCGACCTGATGACGTTCGGCAAGGTGATGGGCGGCGGCTTCCCGGCGGCGGCGTTCGGCG
GTCGCGCCGACGTGATGTCACGGCTGGCGCCCGAGGGCCCCGTCTACCAGGCCGGCACGCTCTCCGGGAACCCGATCGCG
ACGACCGCCGGCCTGGCGACCCTGCGGCTGGCCACCGACGACGTCTACGCCCACATCGGTGCCGCCGCCGACACCATCAA
GACCGCGGCCTCCGACGCGTTGAGCCGGGCCGGGGTCGAGCACGTCGTCCAGGCCGCTGGCACGATGTTCTCGGTGTTCC
TCACCGCCGGCCCCGTGCGCGACTTCGCGGACGCCTCCCGCACCGACGTCGCGGCGTACGCCGCCTTCTTCCACGCGATG
CTCGACCAGGGCGTCTACCTGCCGCCCTCGGCGTACGAGGCGTGGTTCCTGTCCTCCGCCCACGACGACCGGGCCGTCCA
GACCGTGCTCGACGCCCTGCCCACCGCGGCCCGCGCCGCGGCTGCCGCCCAGACGTAG

Upstream 100 bases:

>100_bases
TCCCCCAGGTCATGACGCTGAAACACGTTCTCGCGGTTCCGGGCGGCCCGAGACGCGACCCTGGACGCCGCCGGTTGGCG
TGCTCGGGGACAATGAGGCG

Downstream 100 bases:

>100_bases
GAGCCTCCTGCTGTGAACCAGACCCCTGACACGATCGTCCACCTGCTGCGCCACGGCGAGGTGCACAACCCCGAGGGCGT
CCTCTACGGGCGCCGGGACG

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEYVDLICSWGPMLLGHAHPEVQ
AAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASA
GSGLATFAVPGTPGVPESSTALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCA
RHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMSRLAPEGPVYQAGTLSGNPIA
TTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVEHVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAM
LDQGVYLPPSAYEAWFLSSAHDDRAVQTVLDALPTAARAAAAAQT

Sequences:

>Translated_445_residues
MTAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEYVDLICSWGPMLLGHAHPEVQ
AAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASA
GSGLATFAVPGTPGVPESSTALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCA
RHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMSRLAPEGPVYQAGTLSGNPIA
TTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVEHVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAM
LDQGVYLPPSAYEAWFLSSAHDDRAVQTVLDALPTAARAAAAAQT
>Mature_444_residues
TAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEYVDLICSWGPMLLGHAHPEVQA
AVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASAG
SGLATFAVPGTPGVPESSTALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCAR
HGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMSRLAPEGPVYQAGTLSGNPIAT
TAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVEHVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAML
DQGVYLPPSAYEAWFLSSAHDDRAVQTVLDALPTAARAAAAAQT

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=25.7831325301205, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI4557809, Length=328, Percent_Identity=27.4390243902439, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI37574042, Length=356, Percent_Identity=26.123595505618, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI226442705, Length=355, Percent_Identity=25.6338028169014, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442709, Length=326, Percent_Identity=26.3803680981595, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI284507298, Length=248, Percent_Identity=28.2258064516129, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=50.2347417840376, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789016, Length=313, Percent_Identity=32.2683706070287, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787560, Length=297, Percent_Identity=31.6498316498317, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788044, Length=342, Percent_Identity=29.2397660818713, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693181, Length=294, Percent_Identity=28.9115646258503, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789759, Length=287, Percent_Identity=29.616724738676, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786991, Length=270, Percent_Identity=25.5555555555556, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71992977, Length=336, Percent_Identity=26.1904761904762, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=304, Percent_Identity=27.9605263157895, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25144274, Length=176, Percent_Identity=28.9772727272727, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=311, Percent_Identity=23.7942122186495, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=322, Percent_Identity=24.223602484472, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574759, Length=328, Percent_Identity=26.219512195122, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161085790, Length=328, Percent_Identity=26.219512195122, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_NOCSJ (A1SE06)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921728.1
- ProteinModelPortal:   A1SE06
- SMR:   A1SE06
- STRING:   A1SE06
- GeneID:   4597398
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0499
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   NENAVRD
- PhylomeDB:   A1SE06
- BioCyc:   NSP35761:NOCA_0499-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45632; Mature: 45500

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEY
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCEEECCCCCCE
VDLICSWGPMLLGHAHPEVQAAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVS
EHEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
SGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASAGSGLATFAVPGTPGVPESST
CCHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
ALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCA
EEEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMS
HCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHH
RLAPEGPVYQAGTLSGNPIATTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVE
HHCCCCCCEECCCCCCCCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAMLDQGVYLPPSAYEAWFLSSA
HHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
HDDRAVQTVLDALPTAARAAAAAQT
CCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCEEECCCCCCE
VDLICSWGPMLLGHAHPEVQAAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVS
EHEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
SGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASAGSGLATFAVPGTPGVPESST
CCHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
ALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCA
EEEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMS
HCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHH
RLAPEGPVYQAGTLSGNPIATTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVE
HHCCCCCCEECCCCCCCCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAMLDQGVYLPPSAYEAWFLSSA
HHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
HDDRAVQTVLDALPTAARAAAAAQT
CCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA