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The map label for this gene is hemB [H]

Identifier: 119714761

GI number: 119714761

Start: 527693

End: 528694

Strand: Direct

Name: hemB [H]

Synonym: Noca_0497

Alternate gene names: 119714761

Gene position: 527693-528694 (Clockwise)

Preceding gene: 119714760

Following gene: 119714763

Centisome position: 10.58

GC content: 73.35

Gene sequence:

>1002_bases
ATGAGCGAGGTCCCGGTCCCGCCGGTCGTCGGGCCGACCGTCCGGCCGCGACGGCTGCGCACCACCGCGGCCCTGCGGCG
GATGGTGTCCGAGACCTCGCTCGAGGCCCGGCAGTTGGTGCTGCCGGTGTTCGTCTGCGAGGGCCTCGACGAGCCGCGAC
CGATCTCGTCGATGCCGGGCGTGGTCCAGCACACCCGGTCCTCGCTGCTCGCCGCCGTCACCGAGGCCGCCGAGCTGGGG
CTCGGCGGGGTGATGCTCTTCGGCATCCCGGAGCGCAAGGACGCCGTCGGCTCCGGCGCGGTCGACCCGGCCGGGATCCT
CAACCTCGCGATCACCGACGTGGTCGGCGAGGTGGGCGACGCGCTGACGGTGATGAGCGACCTGTGCCTCGACGAGTTCA
CCGACCACGGGCACTGCGGGGTGCTCACCCCGGACGGCAAGGTCGACAACGACCGCACGCTGAGCCGGTACGCCGAGATG
GCGCTCGCCCAGGCCCACGCAGGCGTCGACATGGTCGGGCCGAGCGGCATGATGGACGGTCAGGTCGCGGTGGTCCGGCG
GGCGCTGGACGCGGCCGGGCACACGGACGTGTCGATCCTGGCGTACTCCGCGAAGTACGCCTCGGCGTTCTTCGGCCCGT
TCCGTGAGGCCGTGGACTCCTCGCTCGAGGGCGACCGCCGCACCTACCAGCAGGACCCCGCCAACGCCCGCGAGGGCGTC
CGGGAGGCCATGCTCGACGTCGAGGAGGGCGCCGACCTGGTGATGGTCAAGCCCGCGCTCGCCTACCTCGACGTGCTGCA
CCGGGTCCGCGACGCCGTCGACGTCCCGGTGGCGGCGTACAACGTCTCCGGCGAGTACGCCATGCTCGAGGCCGCCGCGG
CGAAGGGCTGGATCGACCGCGAGCCCGCGATCCTGGAGGCGCTCACCTCGATCCGCCGGGCCGGCGCCGACGTGGTGCTG
ACCTATTGGGCCGCCGAGGTCGCGCGGATCCTCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGAGGCCGGCCAGCCGGTGACCAAGCCGTCGGACCGCAAGCCGTCCGGCCGCCGGAAGACGACCTCGGCGCGATGAGCCC
GGTCCGATGAGCGAGGTCCG

Downstream 100 bases:

>100_bases
GCGGCCAGCCAGTTTCATCGGCCGGCCGACAGATCTCGACCCTGGACGACAAAGCTTCATCGTCCAGGCGCGAGGTTCAT
CGGCCGGCCGATGAAACTCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPGVVQHTRSSLLAAVTEAAELG
LGGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGDALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEM
ALAQAHAGVDMVGPSGMMDGQVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGV
REAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDREPAILEALTSIRRAGADVVL
TYWAAEVARILAR

Sequences:

>Translated_333_residues
MSEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPGVVQHTRSSLLAAVTEAAELG
LGGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGDALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEM
ALAQAHAGVDMVGPSGMMDGQVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGV
REAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDREPAILEALTSIRRAGADVVL
TYWAAEVARILAR
>Mature_332_residues
SEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPGVVQHTRSSLLAAVTEAAELGL
GGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGDALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEMA
LAQAHAGVDMVGPSGMMDGQVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGVR
EAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDREPAILEALTSIRRAGADVVLT
YWAAEVARILAR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=42.6229508196721, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI87081728, Length=314, Percent_Identity=47.4522292993631, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=39.4230769230769, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21358291, Length=313, Percent_Identity=38.9776357827476, Blast_Score=208, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35419; Mature: 35288

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
VVQHTRSSLLAAVTEAAELGLGGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGD
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEMALAQAHAGVDMVGPSGMMDG
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
QVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGV
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHH
REAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDR
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCC
EPAILEALTSIRRAGADVVLTYWAAEVARILAR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
VVQHTRSSLLAAVTEAAELGLGGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGD
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEMALAQAHAGVDMVGPSGMMDG
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
QVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGV
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHH
REAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDR
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCC
EPAILEALTSIRRAGADVVLTYWAAEVARILAR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]