Click here to switch to the map view.

The map label for this gene is hemA1

Identifier: 119714758

GI number: 119714758

Start: 523685

End: 524977

Strand: Direct

Name: hemA1

Synonym: Noca_0494

Alternate gene names: 119714758

Gene position: 523685-524977 (Clockwise)

Preceding gene: 119714757

Following gene: 119714759

Centisome position: 10.5

GC content: 73.86

Gene sequence:

>1293_bases
GTGAGCGTCCTCGTCGTGGGCATCTCCCACAAGTCGGCGCCCGTCGCCCTGCTCGAGCAGCTGGCCCTCGACGGCCCCGG
GCTGCACAAGCTGATCGACGACGTCGCCGCCAGCGAGCACGTCACCGAGGCCACCGTCATCGCGACCTGCAACCGGCTGG
AGATCTACGCCGAGGTGGACCGCTTCCACGGCAGCGTGGAGGAGGTCTCCCGGCTGGTCGTCGACCGGGCCGGAGAGCGC
ACCGAGGCGATGCTCCCGCACCTCTACGTCCACTACGACGACGGCGCCGTGTCCCACCTGTTCCAGGTGGTCGCCGGCCT
CGACTCGATGGCGGTCGGCGAGGGGCAGATCCTGGGGCAGACGCGCGCGGCACTCAACGCCGGCCAGGAGATCGGGACGG
TCGGGCCGGCCCTCAACGTGTTGTTCCAGCAGGCCCTCCGAGTCGGCAAGCGGGCCCGGGCCGAGACCGGCATCGACCGG
GCCGCGCCGTCGCTCGTCAGCGCCGCCCTGGACCGCAGCCGCGCCACCGTCGGCGAGCTCTCCGGCAAGCGGGTCCTGGT
CGTCGGCGCCGGCTCGATGGCGGGCCTGGCCACCTCCACGGTCGCCGCGCGCGGCACCGCCAGCGTCACGGTCGTCAACC
GGACCTCCGGGAACGCCGACCGGCTCGCCGAGGAGTACGGCGCGCGCTCCGCGACGCTCGCGGAACTGGCGGCCGAGCTC
GCCGTCGCGGACGTGGTGATCTCCTGCACCGGCGCGACCGGCACCCTGATCACCCGCGACATGGTCGCCGCGGCGACCGT
CGACGGGCGCGAGCTGTCCATCCTCGACCTGGCCCTCCCGCACGACGTCGACCCGACGGTCGCCGACCTGCCCGGGGTCA
GCCTCGTCGGCCTCACCGACCTCGCCGACGAGCTGCGCGACTCCGACGCCGGCCAGGAGGTCGAGGCCGTGCGCCAGATC
GTGACCCAGGAGGTCGCGGCGTTCCTCTCGGCCCGCCGCCAGGCGAGCGTCACCCCCACGGTCGTCGCGCTGCGGTCGAT
GGCGACCTCCGTGGTGGAAGCGGAGATGGAGCGCCTCACCAGTCGGGTCCCCGGCCTCGACGACGACATCCGCGCCGAGG
TGCTGCACACCGTCCGCCGGGTCGCGGACAAGCTGCTGCACCAGCCGACCGTGCGGGTCCGCGAGCTGGCGAACGAGACC
GGTGCCGTGTCGTACGCCGCCGCACTCGCCGAGCTGTTCGCGCTCGACCAGGAGGCCGTCGACGCCGTCACCCGACCGGA
GGGCCTGACGTGA

Upstream 100 bases:

>100_bases
TGCTGACCGTGCCCGCGGAGGTCGACGTGCGCAAGGTCGACCTGTCCATCGAGCTGCAGATCCTCGCCTACCACGAGCAG
CGCAAGGGTGCGGTGACAGC

Downstream 100 bases:

>100_bases
GCGCGCCGCTGCGGGTCGGGACCCGCGCCTCCGTCCTGGCGACCACGCAGTCCGGGCTGGTCGCCGACCAGCTCCGCGAG
GCCTTGGGCCGCGAGGTCGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 1

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVDRFHGSVEEVSRLVVDRAGER
TEAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQTRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDR
AAPSLVSAALDRSRATVGELSGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAEL
AVADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTDLADELRDSDAGQEVEAVRQI
VTQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLTSRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANET
GAVSYAAALAELFALDQEAVDAVTRPEGLT

Sequences:

>Translated_430_residues
MSVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVDRFHGSVEEVSRLVVDRAGER
TEAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQTRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDR
AAPSLVSAALDRSRATVGELSGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAEL
AVADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTDLADELRDSDAGQEVEAVRQI
VTQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLTSRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANET
GAVSYAAALAELFALDQEAVDAVTRPEGLT
>Mature_429_residues
SVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVDRFHGSVEEVSRLVVDRAGERT
EAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQTRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDRA
APSLVSAALDRSRATVGELSGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAELA
VADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTDLADELRDSDAGQEVEAVRQIV
TQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLTSRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANETG
AVSYAAALAELFALDQEAVDAVTRPEGLT

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=406, Percent_Identity=32.512315270936, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM11_NOCSJ (A1SE01)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921723.1
- ProteinModelPortal:   A1SE01
- SMR:   A1SE01
- STRING:   A1SE01
- GeneID:   4597393
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0494
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A1SE01
- BioCyc:   NSP35761:NOCA_0494-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 44973; Mature: 44842

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVD
CCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RFHGSVEEVSRLVVDRAGERTEAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQ
HHCCCHHHHHHHHHHCCCCHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHCCCCCHHHHH
TRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDRAAPSLVSAALDRSRATVGEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
SGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAEL
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHH
AVADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTD
HHHHHHEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEHHH
LADELRDSDAGQEVEAVRQIVTQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANETGAVSYAAALAELFALDQEAV
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
DAVTRPEGLT
HHHCCCCCCC
>Mature Secondary Structure 
SVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVD
CEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RFHGSVEEVSRLVVDRAGERTEAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQ
HHCCCHHHHHHHHHHCCCCHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHCCCCCHHHHH
TRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDRAAPSLVSAALDRSRATVGEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
SGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAEL
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHH
AVADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTD
HHHHHHEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEHHH
LADELRDSDAGQEVEAVRQIVTQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANETGAVSYAAALAELFALDQEAV
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
DAVTRPEGLT
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA