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The map label for this gene is nadC [H]

Identifier: 119714727

GI number: 119714727

Start: 493205

End: 494107

Strand: Direct

Name: nadC [H]

Synonym: Noca_0463

Alternate gene names: 119714727

Gene position: 493205-494107 (Clockwise)

Preceding gene: 119714726

Following gene: 119714728

Centisome position: 9.89

GC content: 74.97

Gene sequence:

>903_bases
GTGACCCCGGCGACGCCGTACGACGAGGAGCTCCGCGCCGCCGGCCTCGACCCGGAGGCGATCCGGGCCCAGGTCGCGCG
GGCGCTCGCGGAGGACCTGCCCGGCGGGCTCGCGCGGGGCGACGTCACCTCGGTCGCGACGATCGCCGCCGATGCGCGCG
GCACGGGGGTCTTCGCCGCTCGCGAGGCAGGCGTCGTTGCAGGCCTCGGGGTCGCCGCACTGGTCTTCCACGAGGTCCTG
GGCGACGCGGTCGAGGTGACCGACCGGGTGCCCGACGGCACCCGTGTCGCGCCGGGTGACGTCGTGATGCGGGTCGCCGG
CCCCACCCGCGGGCTGCTCACCGCTGAGCGCACGGCGCTCAACTACGCCAGCCACCTCTCGGGCGTCGCGACCGCCACCG
CGCACTGGGTCGACGCGCTGGCCGGCACCCGCGCCCGGGTGCTCGACACCCGCAAGACGCTCCCGACCTTCCGGGCGCTG
CAGAAGTACGCGGTGCGCTGCGGCGGCGGGGTCAACCACCGGTTCAGCCTCGGCGACCGCGCGATGGTCAAGGACAACCA
CGTGGTCGCCGCCGGCGGTGTGGTGCCGGCGTACGACGCGGTCCGCAGGGCCTATCCGGACCTGCGTGTGGAGGTCGAGG
TCACCGGCCTCGACGAGCTGCGCGAGCTGCTCGACGCGGGCTGCACCGAGATCCTGCTCGACAACATGGACACCGCCACC
ATGGCCGAGGCCGTGCGCCTCACCGCGGGCCGGGCGACCCTCGAGGCGTCCGGCGGCCTGACCATCGAGCGCGCGCGCGA
GGTGGCCGAGACCGGCGTCGACTTCATCTCCGTCGGCGCGCTCACCCATTCGGTCCAGGTCTTCGACCTCGGCCTGGACC
TCTCCTCGGGCAGCGAGGGCTGA

Upstream 100 bases:

>100_bases
GCGACGACGCCGGGTACGCCGGGCACTTCGACGTGGTGATGGCGGACGGCGCCAGCACCCTGCAGCTGGTCCCCGCACCT
CCGACCGACCGGGACGACCG

Downstream 100 bases:

>100_bases
GCGGTGCCGCTGCTCTGTGCCGACATCGGCAACAGCCACACGGTCCTCGGCCTGGTCTCCGGGGGCAGCGTGCTCGCCGA
CTGGCGGGTGGCCACCGACG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTPATPYDEELRAAGLDPEAIRAQVARALAEDLPGGLARGDVTSVATIAADARGTGVFAAREAGVVAGLGVAALVFHEVL
GDAVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTALNYASHLSGVATATAHWVDALAGTRARVLDTRKTLPTFRAL
QKYAVRCGGGVNHRFSLGDRAMVKDNHVVAAGGVVPAYDAVRRAYPDLRVEVEVTGLDELRELLDAGCTEILLDNMDTAT
MAEAVRLTAGRATLEASGGLTIERAREVAETGVDFISVGALTHSVQVFDLGLDLSSGSEG

Sequences:

>Translated_300_residues
MTPATPYDEELRAAGLDPEAIRAQVARALAEDLPGGLARGDVTSVATIAADARGTGVFAAREAGVVAGLGVAALVFHEVL
GDAVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTALNYASHLSGVATATAHWVDALAGTRARVLDTRKTLPTFRAL
QKYAVRCGGGVNHRFSLGDRAMVKDNHVVAAGGVVPAYDAVRRAYPDLRVEVEVTGLDELRELLDAGCTEILLDNMDTAT
MAEAVRLTAGRATLEASGGLTIERAREVAETGVDFISVGALTHSVQVFDLGLDLSSGSEG
>Mature_299_residues
TPATPYDEELRAAGLDPEAIRAQVARALAEDLPGGLARGDVTSVATIAADARGTGVFAAREAGVVAGLGVAALVFHEVLG
DAVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTALNYASHLSGVATATAHWVDALAGTRARVLDTRKTLPTFRALQ
KYAVRCGGGVNHRFSLGDRAMVKDNHVVAAGGVVPAYDAVRRAYPDLRVEVEVTGLDELRELLDAGCTEILLDNMDTATM
AEAVRLTAGRATLEASGGLTIERAREVAETGVDFISVGALTHSVQVFDLGLDLSSGSEG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=293, Percent_Identity=35.4948805460751, Blast_Score=134, Evalue=9e-32,
Organism=Escherichia coli, GI1786299, Length=292, Percent_Identity=46.2328767123288, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321162, Length=292, Percent_Identity=30.1369863013699, Blast_Score=122, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31181; Mature: 31049

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPATPYDEELRAAGLDPEAIRAQVARALAEDLPGGLARGDVTSVATIAADARGTGVFAA
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEE
REAGVVAGLGVAALVFHEVLGDAVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTAL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCHHHHHHHH
NYASHLSGVATATAHWVDALAGTRARVLDTRKTLPTFRALQKYAVRCGGGVNHRFSLGDR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
AMVKDNHVVAAGGVVPAYDAVRRAYPDLRVEVEVTGLDELRELLDAGCTEILLDNMDTAT
EEECCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHCCCCHHH
MAEAVRLTAGRATLEASGGLTIERAREVAETGVDFISVGALTHSVQVFDLGLDLSSGSEG
HHHHHHHHCCCEEEECCCCEEHHHHHHHHHCCCCCEEHHHHHHEEEEEEEEEECCCCCCC
>Mature Secondary Structure 
TPATPYDEELRAAGLDPEAIRAQVARALAEDLPGGLARGDVTSVATIAADARGTGVFAA
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEE
REAGVVAGLGVAALVFHEVLGDAVEVTDRVPDGTRVAPGDVVMRVAGPTRGLLTAERTAL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCHHHHHHHH
NYASHLSGVATATAHWVDALAGTRARVLDTRKTLPTFRALQKYAVRCGGGVNHRFSLGDR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
AMVKDNHVVAAGGVVPAYDAVRRAYPDLRVEVEVTGLDELRELLDAGCTEILLDNMDTAT
EEECCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHCCCCHHH
MAEAVRLTAGRATLEASGGLTIERAREVAETGVDFISVGALTHSVQVFDLGLDLSSGSEG
HHHHHHHHCCCEEEECCCCEEHHHHHHHHHCCCCCEEHHHHHHEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 9862811 [H]