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The map label for this gene is fadH [C]

Identifier: 119714689

GI number: 119714689

Start: 454784

End: 455962

Strand: Direct

Name: fadH [C]

Synonym: Noca_0425

Alternate gene names: 119714689

Gene position: 454784-455962 (Clockwise)

Preceding gene: 119714688

Following gene: 119714690

Centisome position: 9.12

GC content: 72.43

Gene sequence:

>1179_bases
ATGACCGCCGACGTCTTCGCCCCGACCACCCTGGGTCCGGTGCGGCTGCGCAACCGGACGGTGAAGGCGGCGACCTTCGA
GGGCCGGGCGCCGCACGGGCAGGTGACCGACGAGCTGATCGACTACCACCTCGCGGTGACCCACGGCGGCGTCGGGCTGA
CCACCGTCGCCTACCTCGCGGTCGCGCCGGAGGGGCGCACGCACCGCGAGCAGATCGTCGTGGGCGAGCCGACGCTCGCG
GGGCTGACCCGGCTCGCGGACGCGATCCACGAGTCGGGTGCCGCGATCGCGGGTCAGGTCGGACACGCCGGGCCGGTGGC
CAACGGCCGCTCGAACGGCGTCAAGGCGATCAGCGCCAGCCGGATGCCGAGCCCGCTGTCGATGCAGCTGATCCGCTCGG
CGACCGAGGCGGACCTGACCCGGGTCACCAAGGCGTACGTCGCCGCCTCGCGGCTGCTGGTCCGGGCCGGCTTCGACGTG
CTCGAGCTGCACATGGCCCACAGCTACCTGATCTCCTCCTTCCTCGCGCCCGGGCTGAACCGCCGCAAGGACGGCTGGGG
CGGCTCGCTGGCGAACCGAGCGCGGCTGGGCCGCCAGGTCGCCCGCGCCGTACGTGACGAGATCGGGTCGGACGCCGCGA
TCACCGCGAAGGTCAGCGTCGGCGACGGGTTCCGCGGTGGCGTGACGACCGACGAGGGGATCGAGTACGCGCAGCTGCTC
GAGGCCGACGGCACCCTCGACGCGCTGCAGCTCAGCGGCGGCTCGTCGCTCATGAACCCGATGTACCTGTTCCGCGGCGA
GGCCCCGGTCCGGGAGTTCGCGGCCACGATGCCGCTCGTCGTCCGTCTCGGGATGAAGACCCCGGTGGGCCAGAGCTTCC
TCAAGGCCTACCCGTTCGAGGAGGCGTACTTCCGGGAGAAGGCGCTGCGGTTCCGGGAGGCCGTGTCGATGCCGCTGATG
CTGCTCGGCGGCATCAACCGGCTCGCGACCATGGAGCAGGCGATGGCCGAGGGCTTCGACTTCGTCGCCATGGGCCGCGC
CCTGCTCCGCGAGCCCGACCTGGTCGACCGACTCCAGTCCGGCCGAGCCACCGCCGGCGTGTGCATCCACTGCAACCGCT
GCATGCCCACCATCTACTCCGGCACTCGCTGCCCGGTGATCGCCCCCGAGCCGGCCTGA

Upstream 100 bases:

>100_bases
CTTCGTGCCGGCGGCGCTCCCCGTCGCGGGGCTGCTCTGGCTGCGCCGGCAGAAGCGGCCGGCCCTCGCCGCTGACTGAA
ACGTGTTCTAGATTGCCGTC

Downstream 100 bases:

>100_bases
GCCGCCCCGCGCTGGCCTGGCGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGT
TCCGGTTTCCCCGGTTAACC

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLAVAPEGRTHREQIVVGEPTLA
GLTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISASRMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDV
LELHMAHSYLISSFLAPGLNRRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLL
EADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFEEAYFREKALRFREAVSMPLM
LLGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQSGRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA

Sequences:

>Translated_392_residues
MTADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLAVAPEGRTHREQIVVGEPTLA
GLTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISASRMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDV
LELHMAHSYLISSFLAPGLNRRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLL
EADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFEEAYFREKALRFREAVSMPLM
LLGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQSGRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA
>Mature_391_residues
TADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLAVAPEGRTHREQIVVGEPTLAG
LTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISASRMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDVL
ELHMAHSYLISSFLAPGLNRRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLLE
ADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFEEAYFREKALRFREAVSMPLML
LGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQSGRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=388, Percent_Identity=25.5154639175258, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1787939, Length=205, Percent_Identity=34.1463414634146, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564188, Length=409, Percent_Identity=26.161369193154, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559804, Length=410, Percent_Identity=25.609756097561, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559802, Length=380, Percent_Identity=24.7368421052632, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17566914, Length=343, Percent_Identity=27.6967930029155, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72001454, Length=391, Percent_Identity=25.3196930946292, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17565138, Length=390, Percent_Identity=24.6153846153846, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540738, Length=387, Percent_Identity=25.8397932816537, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321973, Length=385, Percent_Identity=24.4155844155844, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325086, Length=83, Percent_Identity=37.3493975903614, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 41814; Mature: 41682

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLA
CCCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHH
VAPEGRTHREQIVVGEPTLAGLTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISAS
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEECC
RMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDVLELHMAHSYLISSFLAPGLN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
RRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
EADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFE
HCCCCEEEEEECCCCHHHCCHHEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
EAYFREKALRFREAVSMPLMLLGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQS
HHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC
GRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA
CCCCCEEEEEECCCCCHHCCCCCCCEECCCCC
>Mature Secondary Structure 
TADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLA
CCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHH
VAPEGRTHREQIVVGEPTLAGLTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISAS
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEECC
RMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDVLELHMAHSYLISSFLAPGLN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
RRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
EADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFE
HCCCCEEEEEECCCCHHHCCHHEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
EAYFREKALRFREAVSMPLMLLGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQS
HHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC
GRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA
CCCCCEEEEEECCCCCHHCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]