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The map label for this gene is menB [H]

Identifier: 119714525

GI number: 119714525

Start: 276111

End: 277028

Strand: Direct

Name: menB [H]

Synonym: Noca_0258

Alternate gene names: 119714525

Gene position: 276111-277028 (Clockwise)

Preceding gene: 119714521

Following gene: 119714526

Centisome position: 5.54

GC content: 69.83

Gene sequence:

>918_bases
ATGAGCGCGATCGACGGGGTGTCGGAGATCTTCGACGCCGACGCCTGGGACGTCGTCCCCGGCTTCGAGGACCTGACCGA
CCTCACCTACCACCGGGCCCGGGAGCACGGCACCGTGCGGGTCGCCTTCGACCGACCCGACGTGCTGAACGCGTTCCGGC
CGCACACGGTCGACGAGCTGCTGCGGGTGCTCGAGCACGCGCGCACGTCCAGCGACGTCGGCTGCGTCCTCCTGACCGGC
AACGGACCGAGCGCGAAGAACGGGAAGTGGGCGTTCTGCACCGGCGGCGACCAGCGGATCCGCGGGCGCGCCGGCTATCA
GTACGCGGAGGGCGAGACCGCCGAGACGGTCGACAAGGCCAAGCTGGGGAGGCTGCACATCCTCGAGGTGCAGCGGCTGA
TCCGATTCATGCCCAAGATCGTCATCTGCGTGGTGCCCGGCTGGACGGCGGGCGGTGGCCACAGCCTGCACGTGGTCTGC
GACCTCACGCTCGCGAGTGCCGAGGAGGCCCGGTTCAAGCAGACCGACGCGGACGTCGGGTCGTTCGACGGCGGGTTCGG
ATCGGCGTACCTCGCCCGCCAGGTCGGCCAGAAGTTCGCCCGCGAGATCTTCTTCCTCGGCCAGGAGTACTCCGCCGAGG
ACGGCGTGCGGATGGGCACCGTCAACCGCGCGGTCCCGCACGCCGAGCTCGAGGCGACCGCGCTGGAGTGGGGCCGGATC
GTCAACGGCAAGTCGCCGACGGCGCAGCGGATGCTCAAGTACTCCTTCAACGCCATCGACGACGGCCTGGTCGGTCAGCA
GCTCTTCGCCGGCGAGACCACCCGCCTGGCGTACATGACCGACGAGGCCCAGGAGGGCCGCGACCAGTTCCTGGAGAAGC
GCGACCCTGACTGGTCGCCGTTCCCCTGGTACTACTGA

Upstream 100 bases:

>100_bases
GACCCATTGCTGGGGGTTGGGCTCGTACTCGCCGTCAAGTGTCATATCTGGTCAATGCCCAGTCGGCCTCGCGGCATTCC
CCGGCGATAGCCTCGCCCGC

Downstream 100 bases:

>100_bases
TGCCGCGCGACCGGGGCAGGTCACCGACGCTGGTCGGACTCTGCGCGCCGAGCAGTTGCGGGCCGTGCCCGGTCGCATGC
TCCGGGGTCAGGACGGACCA

Product: 1,4-dihydroxy-2-naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDELLRVLEHARTSSDVGCVLLTG
NGPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKAKLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVC
DLTLASAEEARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRI
VNGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSPFPWYY

Sequences:

>Translated_305_residues
MSAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDELLRVLEHARTSSDVGCVLLTG
NGPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKAKLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVC
DLTLASAEEARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRI
VNGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSPFPWYY
>Mature_304_residues
SAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDELLRVLEHARTSSDVGCVLLTGN
GPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKAKLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVCD
LTLASAEEARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRIV
NGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSPFPWYY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=277, Percent_Identity=26.3537906137184, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI31542718, Length=268, Percent_Identity=26.1194029850746, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788597, Length=286, Percent_Identity=45.4545454545455, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1787659, Length=275, Percent_Identity=25.8181818181818, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=23.5955056179775, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI221142681, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787660, Length=268, Percent_Identity=27.6119402985075, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=27.4131274131274, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=265, Percent_Identity=26.0377358490566, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 33798; Mature: 33667

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDEL
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCHHHH
LRVLEHARTSSDVGCVLLTGNGPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKA
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHCCCCCCCEECCCCCHHHHHHH
KLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVCDLTLASAEEARFKQTDADVG
HCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEEECCHHHHHHHHCCCCCC
SFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHCCCCCHHHHHHHHHHHH
VNGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSP
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
FPWYY
CCCCC
>Mature Secondary Structure 
SAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDEL
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCHHHH
LRVLEHARTSSDVGCVLLTGNGPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKA
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHCCCCCCCEECCCCCHHHHHHH
KLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVCDLTLASAEEARFKQTDADVG
HCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEEECCHHHHHHHHCCCCCC
SFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHCCCCCHHHHHHHHHHHH
VNGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSP
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
FPWYY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]