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The map label for this gene is hsaA [H]

Identifier: 119714473

GI number: 119714473

Start: 221618

End: 222793

Strand: Direct

Name: hsaA [H]

Synonym: Noca_0206

Alternate gene names: 119714473

Gene position: 221618-222793 (Clockwise)

Preceding gene: 119714462

Following gene: 119714474

Centisome position: 4.44

GC content: 71.09

Gene sequence:

>1176_bases
ATGACAGTCCTCGACGAGATCCGTCGGCTCGAGCCCGAGTTCCGGGCCGGCGAGGAGGAGGCCGCCGAGCTGCGCCGCCT
CCCCGACCAGACCTGGAAGCAGATGCTGGAGAGCGGCCTGCTCCGCGGCCTCCAGCCCCGGCGCTGGGGTGGCGGCGAGC
TGTCGCTGCGCGAGCACCTGACCGGGGTCTACGAGCTCGGCCGGATCGCCCCGTCCGCGGGCTGGGTCTCCGGCGTCGTC
GGCTCGCACCCCTGGCAGGTGGCGCTCTACGACGAGGAGACCCAGCAGGAGGTGTGGGGCGAGGACCCGACGTTCCTGCC
GTCCTCCTCCTACGCGCCGACCGGCAAGATCGTGCCGGTCGACGGCGGCTACCGGGTCAGCGGCCGCTGGTCGTTCTCCT
CCGGCAGCGACCACTGCCAGGGCGTGATCCTGGGCGGCTTCGCCGGCACCATCGAGGTCGCGCCGGGCGTCGAGGTCCCC
AACTTCGGCTCGGCGCTGCTGCTGCGCGACCAGTACGTCATCGAGGACACCTGGCACGTCGCCGGCAGCCGCGGGACCGG
CAGCAAGGACATCGTGGTCGACGACGCGTTCCTGCCGGCCCGCCGGTTCCTCTCCAGCCCGCTCTACGAGTACAACGCCG
ACCGGCCCGCGCCGGGGATCGCGACCAACCCGAACCCGCTCTACCAGGTGCCGTGGGCGGTCATGTTCAACCTGGTGCTG
GTCGCACCGATGCTCGGACTCGGCCGCCGCTTCCTCGACGACTGGACCGCCGAGACCACCACCCGGCGCGCCAACTGGGG
CGGCATGGTCAAGGACGACGCGCTGATGCAGATGCACCTGGCCGAGGCGGAGTGGGTCCACGACGCCGCGGTCAAGAAGA
TGTACGACGCCATCGACACGATCACCGAGGCTGCGGAGGCCGGCGTACGCCTCGACAAGCGCGAGCGGGCCCGGATGCGC
TGGAACATCACCCGCGGCTGCCAGCAGGTCGGGTTCGCCATCAACGACCTGATGCGCGTCGCCAGCGGTCGCACCGTCTT
CACCAGTCACCCCCTGCACCGCCTCTACCAGGACGTCACGGCCGAGCTCGGCCACGCGTTCCTGGTCTCCGACGGCGTCG
GCCAGTACTACGGCGCCTCCCTTCTCGACTCGTCCGCTCCGGAGGTCATGCTGTGA

Upstream 100 bases:

>100_bases
TTGCCAGAACGGTCACTCCAGGGTTACGGTGCCGTACCTGTAGTGATCGTTACAGAGACCTCGGTCACTTCGAACGTTCC
TGAGGGAGAGGCAGCCACGC

Downstream 100 bases:

>100_bases
TCACTCAACTCGCCTACCTGGGGATCGCCTCCCCGAACTACCAGCAGTGGCGCGACTACGGCACCCGCCTGCTCGGCACC
CAGCTCGCCGCGGACGGCCC

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTVLDEIRRLEPEFRAGEEEAAELRRLPDQTWKQMLESGLLRGLQPRRWGGGELSLREHLTGVYELGRIAPSAGWVSGVV
GSHPWQVALYDEETQQEVWGEDPTFLPSSSYAPTGKIVPVDGGYRVSGRWSFSSGSDHCQGVILGGFAGTIEVAPGVEVP
NFGSALLLRDQYVIEDTWHVAGSRGTGSKDIVVDDAFLPARRFLSSPLYEYNADRPAPGIATNPNPLYQVPWAVMFNLVL
VAPMLGLGRRFLDDWTAETTTRRANWGGMVKDDALMQMHLAEAEWVHDAAVKKMYDAIDTITEAAEAGVRLDKRERARMR
WNITRGCQQVGFAINDLMRVASGRTVFTSHPLHRLYQDVTAELGHAFLVSDGVGQYYGASLLDSSAPEVML

Sequences:

>Translated_391_residues
MTVLDEIRRLEPEFRAGEEEAAELRRLPDQTWKQMLESGLLRGLQPRRWGGGELSLREHLTGVYELGRIAPSAGWVSGVV
GSHPWQVALYDEETQQEVWGEDPTFLPSSSYAPTGKIVPVDGGYRVSGRWSFSSGSDHCQGVILGGFAGTIEVAPGVEVP
NFGSALLLRDQYVIEDTWHVAGSRGTGSKDIVVDDAFLPARRFLSSPLYEYNADRPAPGIATNPNPLYQVPWAVMFNLVL
VAPMLGLGRRFLDDWTAETTTRRANWGGMVKDDALMQMHLAEAEWVHDAAVKKMYDAIDTITEAAEAGVRLDKRERARMR
WNITRGCQQVGFAINDLMRVASGRTVFTSHPLHRLYQDVTAELGHAFLVSDGVGQYYGASLLDSSAPEVML
>Mature_390_residues
TVLDEIRRLEPEFRAGEEEAAELRRLPDQTWKQMLESGLLRGLQPRRWGGGELSLREHLTGVYELGRIAPSAGWVSGVVG
SHPWQVALYDEETQQEVWGEDPTFLPSSSYAPTGKIVPVDGGYRVSGRWSFSSGSDHCQGVILGGFAGTIEVAPGVEVPN
FGSALLLRDQYVIEDTWHVAGSRGTGSKDIVVDDAFLPARRFLSSPLYEYNADRPAPGIATNPNPLYQVPWAVMFNLVLV
APMLGLGRRFLDDWTAETTTRRANWGGMVKDDALMQMHLAEAEWVHDAAVKKMYDAIDTITEAAEAGVRLDKRERARMRW
NITRGCQQVGFAINDLMRVASGRTVFTSHPLHRLYQDVTAELGHAFLVSDGVGQYYGASLLDSSAPEVML

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43263; Mature: 43132

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLDEIRRLEPEFRAGEEEAAELRRLPDQTWKQMLESGLLRGLQPRRWGGGELSLREHL
CCHHHHHHHCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
TGVYELGRIAPSAGWVSGVVGSHPWQVALYDEETQQEVWGEDPTFLPSSSYAPTGKIVPV
HHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEEC
DGGYRVSGRWSFSSGSDHCQGVILGGFAGTIEVAPGVEVPNFGSALLLRDQYVIEDTWHV
CCCEEEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEEEECCEEECCHHEE
AGSRGTGSKDIVVDDAFLPARRFLSSPLYEYNADRPAPGIATNPNPLYQVPWAVMFNLVL
CCCCCCCCCCEEEECCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
VAPMLGLGRRFLDDWTAETTTRRANWGGMVKDDALMQMHLAEAEWVHDAAVKKMYDAIDT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEAAEAGVRLDKRERARMRWNITRGCQQVGFAINDLMRVASGRTVFTSHPLHRLYQDVT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
AELGHAFLVSDGVGQYYGASLLDSSAPEVML
HHHCCEEEEECCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVLDEIRRLEPEFRAGEEEAAELRRLPDQTWKQMLESGLLRGLQPRRWGGGELSLREHL
CHHHHHHHCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
TGVYELGRIAPSAGWVSGVVGSHPWQVALYDEETQQEVWGEDPTFLPSSSYAPTGKIVPV
HHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEEC
DGGYRVSGRWSFSSGSDHCQGVILGGFAGTIEVAPGVEVPNFGSALLLRDQYVIEDTWHV
CCCEEEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEEEECCEEECCHHEE
AGSRGTGSKDIVVDDAFLPARRFLSSPLYEYNADRPAPGIATNPNPLYQVPWAVMFNLVL
CCCCCCCCCCEEEECCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
VAPMLGLGRRFLDDWTAETTTRRANWGGMVKDDALMQMHLAEAEWVHDAAVKKMYDAIDT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEAAEAGVRLDKRERARMRWNITRGCQQVGFAINDLMRVASGRTVFTSHPLHRLYQDVT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
AELGHAFLVSDGVGQYYGASLLDSSAPEVML
HHHCCEEEEECCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]