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The map label for this gene is trxC [H]

Identifier: 119714410

GI number: 119714410

Start: 156987

End: 157367

Strand: Reverse

Name: trxC [H]

Synonym: Noca_0143

Alternate gene names: 119714410

Gene position: 157367-156987 (Counterclockwise)

Preceding gene: 119714420

Following gene: 119714409

Centisome position: 3.16

GC content: 70.87

Gene sequence:

>381_bases
ATGACCACCACCACGCTGACTGCCGCGCAGTTCGAGGAGACCGTGACCGGGAACGACATCGTCCTGGTCGACTTCTGGGC
CTCCTGGTGCGGCCCGTGCCGCCAGTTCGCCCCCGTCTTCGAGGCCGCGTCGGAGAAGCACCCCGACGTCGTGTTCGGCA
AGGTCGACACCGAGGCCGAGCGCGAGCTCGCCGCGGCCGCGCAGATCACCTCGATCCCGACGCTGATGGCCTTCCGCGAG
GGCGTGCTCGTCTTCGCCCAGCCGGGCGCCCTGCCGGCGACCTCGCTGGAGCAGGTGATCGGCGCCGTCCGCGAGCTCGA
CATGGACGACGTCCGCGCCCAGCTCGCCGCCCAGAGCCAGGACCAGGAGGAGAACCAGTGA

Upstream 100 bases:

>100_bases
GTTTCGGTACGAGGTCCGGAATACCCCAGGGGGTATCCGCCGTTCGGTACGATAACACCCCGGGGGGTATCGTATTCCCG
GGACGACCAGAGGAGAGCCC

Downstream 100 bases:

>100_bases
GCTTCACGCTGAGCGCGACGGTCGAGCGGCCGTACGACGAGACCGTTGCCGAGGTCCGCGAGGCGCTCGCGGGTCAGGGC
TTCGGGGTCCTCACCGAGAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 126; Mature: 125

Protein sequence:

>126_residues
MTTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAERELAAAAQITSIPTLMAFRE
GVLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQDQEENQ

Sequences:

>Translated_126_residues
MTTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAERELAAAAQITSIPTLMAFRE
GVLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQDQEENQ
>Mature_125_residues
TTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAERELAAAAQITSIPTLMAFREG
VLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQDQEENQ

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=42.1686746987952, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI50592994, Length=90, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788936, Length=78, Percent_Identity=52.5641025641026, Blast_Score=87, Evalue=4e-19,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=35.3535353535354, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=87, Percent_Identity=41.3793103448276, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=80, Percent_Identity=36.25, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=81, Percent_Identity=37.037037037037, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=80, Percent_Identity=36.25, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=80, Percent_Identity=36.25, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=80, Percent_Identity=37.5, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=82, Percent_Identity=36.5853658536585, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115532254, Length=82, Percent_Identity=36.5853658536585, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=102, Percent_Identity=37.2549019607843, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=103, Percent_Identity=34.9514563106796, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=97, Percent_Identity=35.0515463917526, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658597, Length=64, Percent_Identity=42.1875, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13658; Mature: 13527

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAE
CCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
RELAAAAQITSIPTLMAFREGVLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQ
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
DQEENQ
CCCCCC
>Mature Secondary Structure 
TTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAE
CCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
RELAAAAQITSIPTLMAFREGVLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQ
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
DQEENQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]