Click here to switch to the map view.

The map label for this gene is nadB [C]

Identifier: 119714304

GI number: 119714304

Start: 35225

End: 36823

Strand: Direct

Name: nadB [C]

Synonym: Noca_0032

Alternate gene names: 119714304

Gene position: 35225-36823 (Clockwise)

Preceding gene: 119714303

Following gene: 119714305

Centisome position: 0.71

GC content: 73.61

Gene sequence:

>1599_bases
ATGAGCGCGCCCGGAGTGGACCGGGTCGAGGTCGACCTGGTGGTCGCGGGTGGCGGTGTCGGTGGCGCGATGGCGGCATA
CCACGCCGCGCGCGTGGGCGCCAGGGTGCTCTACCTCGGTGGCTCTGGTGGCGCCTCCGCACGCATCAGCAGCTTCAACA
CCGCCCTGGGCTACGACGATCCCGACACCCCCGACGGGATCGTCGAGGACATGCTCCGGGCCGGCCGGCACGTCAACCAT
CCCGGCGTGGTCCGGGCGCTCGCCGACCGCGTCGCGGAGGAGACGATGCGCCTGGTCGAGATGGACGTCCCCTTCGTGCG
CGACGGGGACCGGCTGGCCAGGCGGCAGGCGGCCGGCAGCACGTGGACCCGCGCCGTGTTCTCGCGAGGGATGATCGGCG
CCGACATCGTCCGGGCGCTGACCGAGCGGCTCGTCGCGGACGAATCAGTGACGGTGGTGAACGGCGGCCTGCTGGTCGAC
GTCGAGACCGCGGACGGTGCGGTGTGCGGTGTCCTCGCCTGGAGCCCCCGCGACGAGCGGTGGATGCAGATCGGAACGCG
CGCGGTCGTGATGGCGACCGGTGGGGCGGGCCAGCTGTGGGCGTCGACGACCAACCCGCGCGGCAGCCTGGGCACCGGGT
ACGCCGTGGCCCTCGAGGCCGGCGCCGAGCTGATGGACATGGAGTTCACCTCCTTCGAGCCGTTCATCACGTCGGCGCCC
CCCGAGCACGCGGGTCACGACCTCCCCACGACCGTGTTGCGGGAGGGCGCGCGCCTGCTCAACGCTCGAGGCGAGGCCTT
CCTGCCCGAGCAGAGCCCCACCAAGGACATCATCTGCCGGGCGATGGTCCGTGAGGTGCTGGAGGGGCGCGGCACCGCCT
CGGGCTCGGTCGTCTTCGACCTGACGGAGATGGACCCGGACAACGCCGAGCGCTACGTCGGCATCGTCGAGGCGTTGCGC
AAGCGCGGGATCACGAGCCGTGAGGCGCAGCTCGAGGTGATGCCGGCCCAGCACTACGTCATGGGCGGGATCCGGATCGA
CGAGCGCGGCCGCTCCACGTTGCCGGGGATGTACGCGGTCGGAGAGGCGGCCGGCGGGGCGCACGGTGCCCACCGGCTCG
CCGCCGGCGGTGGCCTCGAGGTGGTCGCCGGGGGCGCGGTGGTGGGCGAGGCCGCAGGCCTGGATGCCCTGTCCGCGACC
GGCGACCGGCGCTGCTCGCTGGCGCCGAACCCGGACCTGCTCAGCGTCCGGCTGGCGGCCGAGGCGCAGGCCGACCTCGG
CCTGATCCGTGGGGCCATGGACTCGGGGTGCGGCATCCTGCGGACCGCCACCGACCTCGAGGACACCGTGACGGCCGTCG
AGGAGGTCCACCAGCGGCACCGGGTGCCGGGCGGGCACCCGTTCGTCCGGCGGGCCGCGATGGTCGCACTCTCGATCGCC
CGGTCGGCCGCGATGCGCGAGGAGTCGCGCGGCGACCACTTCCGCACCGATCACCCCCACAGCTCCGAGGAATGGCTCGC
CAACATCGTGGTGACGGCCCCGGCGGGCGAGATGGAGTTCACGACCGCGCCCGTCCCGACCGCGACGACCGTGGCCTAG

Upstream 100 bases:

>100_bases
GCAACCAGGATGGCGTCCTGGTGCAGGAGGCCGAGCACCGGCGGATGGTGCGGCGTCGTCCGGCCGACGGCGAGCCCGGG
GCGCCCGAGGGCGGCCGCGG

Downstream 100 bases:

>100_bases
TGCCGCCGAAGGAGACCTGATGAAGCCCGAGGAGCTCAGACCCCACCTGGCGGGCGTCGCGTCGGTGGCGATCACGCCGT
TCGACGAGGACCGGCGCGTG

Product: fumarate reductase/succinate dehydrogenase flavoprotein domain-containing protein

Products: fumarate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSAPGVDRVEVDLVVAGGGVGGAMAAYHAARVGARVLYLGGSGGASARISSFNTALGYDDPDTPDGIVEDMLRAGRHVNH
PGVVRALADRVAEETMRLVEMDVPFVRDGDRLARRQAAGSTWTRAVFSRGMIGADIVRALTERLVADESVTVVNGGLLVD
VETADGAVCGVLAWSPRDERWMQIGTRAVVMATGGAGQLWASTTNPRGSLGTGYAVALEAGAELMDMEFTSFEPFITSAP
PEHAGHDLPTTVLREGARLLNARGEAFLPEQSPTKDIICRAMVREVLEGRGTASGSVVFDLTEMDPDNAERYVGIVEALR
KRGITSREAQLEVMPAQHYVMGGIRIDERGRSTLPGMYAVGEAAGGAHGAHRLAAGGGLEVVAGGAVVGEAAGLDALSAT
GDRRCSLAPNPDLLSVRLAAEAQADLGLIRGAMDSGCGILRTATDLEDTVTAVEEVHQRHRVPGGHPFVRRAAMVALSIA
RSAAMREESRGDHFRTDHPHSSEEWLANIVVTAPAGEMEFTTAPVPTATTVA

Sequences:

>Translated_532_residues
MSAPGVDRVEVDLVVAGGGVGGAMAAYHAARVGARVLYLGGSGGASARISSFNTALGYDDPDTPDGIVEDMLRAGRHVNH
PGVVRALADRVAEETMRLVEMDVPFVRDGDRLARRQAAGSTWTRAVFSRGMIGADIVRALTERLVADESVTVVNGGLLVD
VETADGAVCGVLAWSPRDERWMQIGTRAVVMATGGAGQLWASTTNPRGSLGTGYAVALEAGAELMDMEFTSFEPFITSAP
PEHAGHDLPTTVLREGARLLNARGEAFLPEQSPTKDIICRAMVREVLEGRGTASGSVVFDLTEMDPDNAERYVGIVEALR
KRGITSREAQLEVMPAQHYVMGGIRIDERGRSTLPGMYAVGEAAGGAHGAHRLAAGGGLEVVAGGAVVGEAAGLDALSAT
GDRRCSLAPNPDLLSVRLAAEAQADLGLIRGAMDSGCGILRTATDLEDTVTAVEEVHQRHRVPGGHPFVRRAAMVALSIA
RSAAMREESRGDHFRTDHPHSSEEWLANIVVTAPAGEMEFTTAPVPTATTVA
>Mature_531_residues
SAPGVDRVEVDLVVAGGGVGGAMAAYHAARVGARVLYLGGSGGASARISSFNTALGYDDPDTPDGIVEDMLRAGRHVNHP
GVVRALADRVAEETMRLVEMDVPFVRDGDRLARRQAAGSTWTRAVFSRGMIGADIVRALTERLVADESVTVVNGGLLVDV
ETADGAVCGVLAWSPRDERWMQIGTRAVVMATGGAGQLWASTTNPRGSLGTGYAVALEAGAELMDMEFTSFEPFITSAPP
EHAGHDLPTTVLREGARLLNARGEAFLPEQSPTKDIICRAMVREVLEGRGTASGSVVFDLTEMDPDNAERYVGIVEALRK
RGITSREAQLEVMPAQHYVMGGIRIDERGRSTLPGMYAVGEAAGGAHGAHRLAAGGGLEVVAGGAVVGEAAGLDALSATG
DRRCSLAPNPDLLSVRLAAEAQADLGLIRGAMDSGCGILRTATDLEDTVTAVEEVHQRHRVPGGHPFVRRAAMVALSIAR
SAAMREESRGDHFRTDHPHSSEEWLANIVVTAPAGEMEFTTAPVPTATTVA

Specific function: Catalyzes The Oxidation Of L-Aspartate To Iminoaspartate. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=506, Percent_Identity=25.6916996047431, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1788928, Length=525, Percent_Identity=28, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1790597, Length=491, Percent_Identity=26.4765784114053, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786942, Length=515, Percent_Identity=26.7961165048544, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550100, Length=391, Percent_Identity=26.5984654731458, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17505833, Length=379, Percent_Identity=25.065963060686, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322701, Length=400, Percent_Identity=28.25, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322416, Length=508, Percent_Identity=26.9685039370079, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17137288, Length=388, Percent_Identity=29.1237113402062, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24655642, Length=388, Percent_Identity=29.1237113402062, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24655647, Length=388, Percent_Identity=29.1237113402062, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663005, Length=384, Percent_Identity=27.0833333333333, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: 1.3.99.1

Molecular weight: Translated: 55807; Mature: 55675

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGVDRVEVDLVVAGGGVGGAMAAYHAARVGARVLYLGGSGGASARISSFNTALGYDD
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCC
PDTPDGIVEDMLRAGRHVNHPGVVRALADRVAEETMRLVEMDVPFVRDGDRLARRQAAGS
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
TWTRAVFSRGMIGADIVRALTERLVADESVTVVNGGLLVDVETADGAVCGVLAWSPRDER
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCEEEEEEECCCCHH
WMQIGTRAVVMATGGAGQLWASTTNPRGSLGTGYAVALEAGAELMDMEFTSFEPFITSAP
HHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCC
PEHAGHDLPTTVLREGARLLNARGEAFLPEQSPTKDIICRAMVREVLEGRGTASGSVVFD
CCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEE
LTEMDPDNAERYVGIVEALRKRGITSREAQLEVMPAQHYVMGGIRIDERGRSTLPGMYAV
EECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCEEECCCCCCCCCCCEEE
GEAAGGAHGAHRLAAGGGLEVVAGGAVVGEAAGLDALSATGDRRCSLAPNPDLLSVRLAA
CCCCCCCCCHHHHCCCCCEEEEECCEEEECCCCCCHHHCCCCCEECCCCCCCEEEEEEEH
EAQADLGLIRGAMDSGCGILRTATDLEDTVTAVEEVHQRHRVPGGHPFVRRAAMVALSIA
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RSAAMREESRGDHFRTDHPHSSEEWLANIVVTAPAGEMEFTTAPVPTATTVA
HHHHHHHHHCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
SAPGVDRVEVDLVVAGGGVGGAMAAYHAARVGARVLYLGGSGGASARISSFNTALGYDD
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCC
PDTPDGIVEDMLRAGRHVNHPGVVRALADRVAEETMRLVEMDVPFVRDGDRLARRQAAGS
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
TWTRAVFSRGMIGADIVRALTERLVADESVTVVNGGLLVDVETADGAVCGVLAWSPRDER
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCEEEEEEECCCCHH
WMQIGTRAVVMATGGAGQLWASTTNPRGSLGTGYAVALEAGAELMDMEFTSFEPFITSAP
HHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCC
PEHAGHDLPTTVLREGARLLNARGEAFLPEQSPTKDIICRAMVREVLEGRGTASGSVVFD
CCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEE
LTEMDPDNAERYVGIVEALRKRGITSREAQLEVMPAQHYVMGGIRIDERGRSTLPGMYAV
EECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCEEECCCCCCCCCCCEEE
GEAAGGAHGAHRLAAGGGLEVVAGGAVVGEAAGLDALSATGDRRCSLAPNPDLLSVRLAA
CCCCCCCCCHHHHCCCCCEEEEECCEEEECCCCCCHHHCCCCCEECCCCCCCEEEEEEEH
EAQADLGLIRGAMDSGCGILRTATDLEDTVTAVEEVHQRHRVPGGHPFVRRAAMVALSIA
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RSAAMREESRGDHFRTDHPHSSEEWLANIVVTAPAGEMEFTTAPVPTATTVA
HHHHHHHHHCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]