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The map label for this gene is gyrB [H]

Identifier: 119714278

GI number: 119714278

Start: 6391

End: 8526

Strand: Direct

Name: gyrB [H]

Synonym: Noca_0006

Alternate gene names: 119714278

Gene position: 6391-8526 (Clockwise)

Preceding gene: 119714277

Following gene: 119714279

Centisome position: 0.13

GC content: 68.68

Gene sequence:

>2136_bases
GTGTCGGACGAGACCCCGATCGAGAACCCGGCGGAGGGCGGCTCCGGCACAGCCGCCGCAGAGGCCACCGACCGTCGCCC
CAACGGGGTCGACTACGACGCCTCGGCCATCCAGGTCCTCGAGGGCCTCGAAGCCGTTCGCAAGCGTCCCGGGATGTACA
TCGGCTCGACCGGTGAGCGCGGCCTGCACCACCTGATCTGGGAGATCGTGGACAACGCGGTCGACGAGGCGCTCGCGGGC
TACTGCGACCGCATCGTGCTGACGCTCCTGGCCGACGGCGGCATCCGCGTCGAGGACAACGGGCGCGGCATCCCGACCGG
CACCGCGCCGGGACAGGAGCTGCCGGCGCTCACGCTGGCCCTGACCGTGCTCCACGCCGGCGGCAAGTTCGGCGGCGGCG
GCTACAAGGTCTCCGGCGGCCTGCACGGCGTCGGCGTCTCGGTGGTGAACGCCCTCTCCACCCGCCTGGTCGCCGAGGTC
AAGAACCGCGGCCACCTGTGGCGGCAGAGCTTCTCGGCCGGTGTGCCCGACGGCGAGCTCGAGCAGGTCCGGCCGGTGGA
GCCCGACGAGGGCACCGGCACCACGATCACGTACTGGGCCTCCCCCGACATCTTCGAGACCACGACCCACTCGCTGGAGA
CCATCACCTCGCGGATCCGCGAGTACGCCTTCCTCAACAAGGGCCTGGAGATCGTCGTACGCGACGAGCGCCCGGCGGCC
GCCGAGATCGTCGACGCGGTCGAGGACGACACCGTCGACCCGGATCACCGCGGGGGGATCGACGACGCCGGGCACGACGC
GATCAAGCGTGGGGAGGGCGGCGCGCTCGAGCAGATCTTCAAGTACGACCGCGGCCTGATCGACTATGTCGAGCACCTCA
ACCGCCGCAAGACCGCCGCGAACCCGACGGTGATCGCGTTCGAGGCGGAGACGCCGGAGTCGGTCGAGAACCACATGAGC
CTCGAGGTGGCGATGCAGTGGAACACCTCCTTCTCGGAGTCGGTCCACACCTTCGCCAACACCATCAACACCCACGAGGG
CGGCACCCACGAGGAGGGGTTCCGCGCCGCGCTCACCTCCCTGGTCAACAACTGGGGGTTCGAGTGGGGGCTGATGAAGA
AGCCGGAGGACCGGGTCTCCGGTGACGACATCCGCGAGGGCCTGACCGCGATCATCTCGATCAAGCTCGGTGAACCCCAG
TTCGAGGGCCAGACCAAGACCAAGCTCGGCAACACCGAGGCCAAGGGCTTCGTGCAGCGACTGGTCAACGACCAGCTCGG
CGCCTGGCTCGAGCAGAACCCGGCCGAGGGCCGCGACATCGTCCGCAAGGCCCAGGCCGCGGCGTCCGCCCGGATCGCGG
CGCGCAAGGCCCGCGACCTGGCTCGCTCCCGCAAGGGTCTGCTCGGTGGCGGTGGCCTGCCCGGCAAGCTCTCGGACTGC
CAGTCGACCAACCCCGCCGAGTGCGAGGTGTTCATCGTCGAGGGTGACTCCGCCGGTGGGTCGGCCCGCCAGGGCCGGGA
CCCCCGGATCCAGGCGATCCTCCCGATCCGCGGCAAGATCCTCAACGTCGAGAAGGCCCGCATCGACAAGGTCCTGAGCA
ACCAGGAGGTCCAGTCGATCATCTCGGCGCTGGGCACCGGCATCCAGGACGAGTTCGACATCGAGAAGCTGCGCTACCAC
AAGGTGGTGCTGATGGCCGACGCCGACGTCGACGGCCACCACATCAACACCCTGCTGCTCACCTTGCTGTTCCGGTTCAT
GAAGCCGCTGATCGAAGGCGGCTACGTCTACATGGCCCAGCCGCCGCTGTACCGGCTGCGCTGGAACAAGCCGCACGAGC
ACGAGTTCGTCTACTCCGACGCCGAGCGCGACGCCTTGCTGCGCGCGGGCCAGGAGGCCGGCAAGAAGCTGCCGAAGGAG
AACCCGGTCCAGCGCTACAAGGGTCTGGGCGAGATGAACGCCAAGGAGCTGTGGGAGACCACCATGGACCCGGAGCAGCG
GCTGATGCTCCAGGTCACGCTCGACGACGCGGCGCACGCCGACGAGATCTTCTCGATCCTCATGGGTGAGGACGTCGAGC
AGCGCCGCTCCTTCATCCAGCGCAACGCCAAGGACGTCCGATTCCTGGATATCTAG

Upstream 100 bases:

>100_bases
TCGTGCGACGACCCTGCGCATGTTCAGTGCGTGTCCCAGGTGCGTGTGTGTCCACGCCTCCCCGACGCTGCTCGGGGCGG
CCCGTCGCGAAGAGGTGTGT

Downstream 100 bases:

>100_bases
CCGTCTAGGAAGAGCGCTAGATACCAGTAGAAGCGACCAGAAAGAAGCATCGTGACCGAGACCCCCACCGACGGCGGCAG
CACTCCCCCCTCGGACGGCG

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MSDETPIENPAEGGSGTAAAEATDRRPNGVDYDASAIQVLEGLEAVRKRPGMYIGSTGERGLHHLIWEIVDNAVDEALAG
YCDRIVLTLLADGGIRVEDNGRGIPTGTAPGQELPALTLALTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTRLVAEV
KNRGHLWRQSFSAGVPDGELEQVRPVEPDEGTGTTITYWASPDIFETTTHSLETITSRIREYAFLNKGLEIVVRDERPAA
AEIVDAVEDDTVDPDHRGGIDDAGHDAIKRGEGGALEQIFKYDRGLIDYVEHLNRRKTAANPTVIAFEAETPESVENHMS
LEVAMQWNTSFSESVHTFANTINTHEGGTHEEGFRAALTSLVNNWGFEWGLMKKPEDRVSGDDIREGLTAIISIKLGEPQ
FEGQTKTKLGNTEAKGFVQRLVNDQLGAWLEQNPAEGRDIVRKAQAAASARIAARKARDLARSRKGLLGGGGLPGKLSDC
QSTNPAECEVFIVEGDSAGGSARQGRDPRIQAILPIRGKILNVEKARIDKVLSNQEVQSIISALGTGIQDEFDIEKLRYH
KVVLMADADVDGHHINTLLLTLLFRFMKPLIEGGYVYMAQPPLYRLRWNKPHEHEFVYSDAERDALLRAGQEAGKKLPKE
NPVQRYKGLGEMNAKELWETTMDPEQRLMLQVTLDDAAHADEIFSILMGEDVEQRRSFIQRNAKDVRFLDI

Sequences:

>Translated_711_residues
MSDETPIENPAEGGSGTAAAEATDRRPNGVDYDASAIQVLEGLEAVRKRPGMYIGSTGERGLHHLIWEIVDNAVDEALAG
YCDRIVLTLLADGGIRVEDNGRGIPTGTAPGQELPALTLALTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTRLVAEV
KNRGHLWRQSFSAGVPDGELEQVRPVEPDEGTGTTITYWASPDIFETTTHSLETITSRIREYAFLNKGLEIVVRDERPAA
AEIVDAVEDDTVDPDHRGGIDDAGHDAIKRGEGGALEQIFKYDRGLIDYVEHLNRRKTAANPTVIAFEAETPESVENHMS
LEVAMQWNTSFSESVHTFANTINTHEGGTHEEGFRAALTSLVNNWGFEWGLMKKPEDRVSGDDIREGLTAIISIKLGEPQ
FEGQTKTKLGNTEAKGFVQRLVNDQLGAWLEQNPAEGRDIVRKAQAAASARIAARKARDLARSRKGLLGGGGLPGKLSDC
QSTNPAECEVFIVEGDSAGGSARQGRDPRIQAILPIRGKILNVEKARIDKVLSNQEVQSIISALGTGIQDEFDIEKLRYH
KVVLMADADVDGHHINTLLLTLLFRFMKPLIEGGYVYMAQPPLYRLRWNKPHEHEFVYSDAERDALLRAGQEAGKKLPKE
NPVQRYKGLGEMNAKELWETTMDPEQRLMLQVTLDDAAHADEIFSILMGEDVEQRRSFIQRNAKDVRFLDI
>Mature_710_residues
SDETPIENPAEGGSGTAAAEATDRRPNGVDYDASAIQVLEGLEAVRKRPGMYIGSTGERGLHHLIWEIVDNAVDEALAGY
CDRIVLTLLADGGIRVEDNGRGIPTGTAPGQELPALTLALTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTRLVAEVK
NRGHLWRQSFSAGVPDGELEQVRPVEPDEGTGTTITYWASPDIFETTTHSLETITSRIREYAFLNKGLEIVVRDERPAAA
EIVDAVEDDTVDPDHRGGIDDAGHDAIKRGEGGALEQIFKYDRGLIDYVEHLNRRKTAANPTVIAFEAETPESVENHMSL
EVAMQWNTSFSESVHTFANTINTHEGGTHEEGFRAALTSLVNNWGFEWGLMKKPEDRVSGDDIREGLTAIISIKLGEPQF
EGQTKTKLGNTEAKGFVQRLVNDQLGAWLEQNPAEGRDIVRKAQAAASARIAARKARDLARSRKGLLGGGGLPGKLSDCQ
STNPAECEVFIVEGDSAGGSARQGRDPRIQAILPIRGKILNVEKARIDKVLSNQEVQSIISALGTGIQDEFDIEKLRYHK
VVLMADADVDGHHINTLLLTLLFRFMKPLIEGGYVYMAQPPLYRLRWNKPHEHEFVYSDAERDALLRAGQEAGKKLPKEN
PVQRYKGLGEMNAKELWETTMDPEQRLMLQVTLDDAAHADEIFSILMGEDVEQRRSFIQRNAKDVRFLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=356, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI19913406, Length=369, Percent_Identity=26.8292682926829, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI48994957, Length=586, Percent_Identity=46.9283276450512, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789408, Length=675, Percent_Identity=37.037037037037, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=599, Percent_Identity=23.3722871452421, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17535065, Length=725, Percent_Identity=22.7586206896552, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212645657, Length=197, Percent_Identity=29.9492385786802, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=427, Percent_Identity=25.7611241217799, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=693, Percent_Identity=21.7893217893218, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 77867; Mature: 77736

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDETPIENPAEGGSGTAAAEATDRRPNGVDYDASAIQVLEGLEAVRKRPGMYIGSTGER
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCH
GLHHLIWEIVDNAVDEALAGYCDRIVLTLLADGGIRVEDNGRGIPTGTAPGQELPALTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHH
LTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTRLVAEVKNRGHLWRQSFSAGVPDGEL
HHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCH
EQVRPVEPDEGTGTTITYWASPDIFETTTHSLETITSRIREYAFLNKGLEIVVRDERPAA
HHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHH
AEIVDAVEDDTVDPDHRGGIDDAGHDAIKRGEGGALEQIFKYDRGLIDYVEHLNRRKTAA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
NPTVIAFEAETPESVENHMSLEVAMQWNTSFSESVHTFANTINTHEGGTHEEGFRAALTS
CCEEEEEECCCCHHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVNNWGFEWGLMKKPEDRVSGDDIREGLTAIISIKLGEPQFEGQTKTKLGNTEAKGFVQR
HHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEEECCCCCCCCCHHCCCCHHHHHHHHH
LVNDQLGAWLEQNPAEGRDIVRKAQAAASARIAARKARDLARSRKGLLGGGGLPGKLSDC
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QSTNPAECEVFIVEGDSAGGSARQGRDPRIQAILPIRGKILNVEKARIDKVLSNQEVQSI
CCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCHHHHHHH
ISALGTGIQDEFDIEKLRYHKVVLMADADVDGHHINTLLLTLLFRFMKPLIEGGYVYMAQ
HHHHCCCCCCCHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPLYRLRWNKPHEHEFVYSDAERDALLRAGQEAGKKLPKENPVQRYKGLGEMNAKELWET
CCCEEEECCCCCCCCEEECCCHHHHHHHCCHHHHHCCCCCCHHHHHCCCCCCCHHHHHHH
TMDPEQRLMLQVTLDDAAHADEIFSILMGEDVEQRRSFIQRNAKDVRFLDI
CCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
SDETPIENPAEGGSGTAAAEATDRRPNGVDYDASAIQVLEGLEAVRKRPGMYIGSTGER
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCH
GLHHLIWEIVDNAVDEALAGYCDRIVLTLLADGGIRVEDNGRGIPTGTAPGQELPALTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHH
LTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTRLVAEVKNRGHLWRQSFSAGVPDGEL
HHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCH
EQVRPVEPDEGTGTTITYWASPDIFETTTHSLETITSRIREYAFLNKGLEIVVRDERPAA
HHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHH
AEIVDAVEDDTVDPDHRGGIDDAGHDAIKRGEGGALEQIFKYDRGLIDYVEHLNRRKTAA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
NPTVIAFEAETPESVENHMSLEVAMQWNTSFSESVHTFANTINTHEGGTHEEGFRAALTS
CCEEEEEECCCCHHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVNNWGFEWGLMKKPEDRVSGDDIREGLTAIISIKLGEPQFEGQTKTKLGNTEAKGFVQR
HHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEEECCCCCCCCCHHCCCCHHHHHHHHH
LVNDQLGAWLEQNPAEGRDIVRKAQAAASARIAARKARDLARSRKGLLGGGGLPGKLSDC
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QSTNPAECEVFIVEGDSAGGSARQGRDPRIQAILPIRGKILNVEKARIDKVLSNQEVQSI
CCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCHHHHHHH
ISALGTGIQDEFDIEKLRYHKVVLMADADVDGHHINTLLLTLLFRFMKPLIEGGYVYMAQ
HHHHCCCCCCCHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPLYRLRWNKPHEHEFVYSDAERDALLRAGQEAGKKLPKENPVQRYKGLGEMNAKELWET
CCCEEEECCCCCCCCEEECCCHHHHHHHCCHHHHHCCCCCCHHHHHCCCCCCCHHHHHHH
TMDPEQRLMLQVTLDDAAHADEIFSILMGEDVEQRRSFIQRNAKDVRFLDI
CCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7828880; 12000953 [H]