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The map label for this gene is mutM

Identifier: 119387217

GI number: 119387217

Start: 1727837

End: 1728682

Strand: Direct

Name: mutM

Synonym: Pden_4512

Alternate gene names: 119387217

Gene position: 1727837-1728682 (Clockwise)

Preceding gene: 119387212

Following gene: 119387218

Centisome position: 99.87

GC content: 71.39

Gene sequence:

>846_bases
ATGCCAGAACTGCCAGAGGTCGAAACCGTCCGACGCGGCCTTCAGCCGCATCTCGAAGGCCGGGTGATCGCCCGTGCCGA
AGCCCGCCGCCCCGACCTGCGCTGGCCCCTGCCGCCCGATCTGGTGCAGGTGCTGACCGGCGCGCGGGTCGTCGCCCTGC
GGCGGCGCTCGAAATACATCCTGGCCGAGCTGGAGGATCGCGGCAGCCTGCTTCTGCATCTGGGCATGTCGGGGCGGATG
CTAATCGAGGGGGAAAGCCAGGGCGATTTCCACCGCGACCCGGCGATCCTGCCGCGCCACGACCATGTGGTGCTGTGGAA
CGACCAGGGCACGCGCATCACCTTCAACGACGCGCGGCGATTCGGCATGGTCGATCTGGTGCCGCCGGGGGCCGAGCATC
CGCTGCTGGCGCATCTGGGGCCCGAGCCGCTGTCGGACGCCTTCACCGCCGAGGCGCTGGCGGCGGCCTTCGCCGGGCGG
CGCATGCCGGTCAAGGCAGCGCTGCTCGACCAGCGAATCGTGGCGGGGCTGGGCAATATCTACGTCTCCGAGGCGCTCTA
TCGCGCCGGCATCGACCCGCGCCGTCTGGCCGGAGCGGTCACCGCCCCCGAGGTGGCGGCGCTGGTCGGCCATGTCCGTG
CCGTTCTGGAGGAGGCGATCGCGGCCGGGGGCTCCAGCCTGCGCGACCACCGGCAGGCGACCGGAGAGCTGGGCTATTTC
CAGCACTCCTTCCGCGTCTATGGCCGCGAGGGTGCGCCCTGCCCGACGCCGGGCTGCACGGGCACGGTCCAGCGCATCGT
GCAGTCCGGGCGGTCGAGCTTTTTCTGCCCGCTCTGCCAGCAGTGA

Upstream 100 bases:

>100_bases
GTCGCTTGTCCATCCGTCGTTTCGCGCCCAGATAGTCCGAAAGCGCGCCGCGCGCCATAGCTGGGGACGCGGGCCGCACC
ATGCGACGAACGGGAAGAAA

Downstream 100 bases:

>100_bases
AGGGGCTCCTTCCCCACGCCTGAGCCGGTGATATCGGCAGGCGCTGGCCTTGGCCTCGCGCATTTGTTACGAGTCGCGGT
CAGCTTGTTTGCGAAAGGCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MPELPEVETVRRGLQPHLEGRVIARAEARRPDLRWPLPPDLVQVLTGARVVALRRRSKYILAELEDRGSLLLHLGMSGRM
LIEGESQGDFHRDPAILPRHDHVVLWNDQGTRITFNDARRFGMVDLVPPGAEHPLLAHLGPEPLSDAFTAEALAAAFAGR
RMPVKAALLDQRIVAGLGNIYVSEALYRAGIDPRRLAGAVTAPEVAALVGHVRAVLEEAIAAGGSSLRDHRQATGELGYF
QHSFRVYGREGAPCPTPGCTGTVQRIVQSGRSSFFCPLCQQ

Sequences:

>Translated_281_residues
MPELPEVETVRRGLQPHLEGRVIARAEARRPDLRWPLPPDLVQVLTGARVVALRRRSKYILAELEDRGSLLLHLGMSGRM
LIEGESQGDFHRDPAILPRHDHVVLWNDQGTRITFNDARRFGMVDLVPPGAEHPLLAHLGPEPLSDAFTAEALAAAFAGR
RMPVKAALLDQRIVAGLGNIYVSEALYRAGIDPRRLAGAVTAPEVAALVGHVRAVLEEAIAAGGSSLRDHRQATGELGYF
QHSFRVYGREGAPCPTPGCTGTVQRIVQSGRSSFFCPLCQQ
>Mature_280_residues
PELPEVETVRRGLQPHLEGRVIARAEARRPDLRWPLPPDLVQVLTGARVVALRRRSKYILAELEDRGSLLLHLGMSGRML
IEGESQGDFHRDPAILPRHDHVVLWNDQGTRITFNDARRFGMVDLVPPGAEHPLLAHLGPEPLSDAFTAEALAAAFAGRR
MPVKAALLDQRIVAGLGNIYVSEALYRAGIDPRRLAGAVTAPEVAALVGHVRAVLEEAIAAGGSSLRDHRQATGELGYFQ
HSFRVYGREGAPCPTPGCTGTVQRIVQSGRSSFFCPLCQQ

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=283, Percent_Identity=40.9893992932862, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1786932, Length=290, Percent_Identity=24.4827586206897, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PARDP (A1BAN2)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_918272.1
- ProteinModelPortal:   A1BAN2
- SMR:   A1BAN2
- STRING:   A1BAN2
- GeneID:   4583062
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_4512
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   FLKVHTK
- PhylomeDB:   A1BAN2
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30670; Mature: 30538

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 271-271 BINDING 100-100 BINDING 119-119 BINDING 160-160

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLQPHLEGRVIARAEARRPDLRWPLPPDLVQVLTGARVVALRRRSKYI
CCCCCCHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCHHHHHHHCCCHHEEHHHCCCEE
LAELEDRGSLLLHLGMSGRMLIEGESQGDFHRDPAILPRHDHVVLWNDQGTRITFNDARR
EEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCC
FGMVDLVPPGAEHPLLAHLGPEPLSDAFTAEALAAAFAGRRMPVKAALLDQRIVAGLGNI
CCCEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YVSEALYRAGIDPRRLAGAVTAPEVAALVGHVRAVLEEAIAAGGSSLRDHRQATGELGYF
HHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHH
QHSFRVYGREGAPCPTPGCTGTVQRIVQSGRSSFFCPLCQQ
HHEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLQPHLEGRVIARAEARRPDLRWPLPPDLVQVLTGARVVALRRRSKYI
CCCCCHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCHHHHHHHCCCHHEEHHHCCCEE
LAELEDRGSLLLHLGMSGRMLIEGESQGDFHRDPAILPRHDHVVLWNDQGTRITFNDARR
EEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCC
FGMVDLVPPGAEHPLLAHLGPEPLSDAFTAEALAAAFAGRRMPVKAALLDQRIVAGLGNI
CCCEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YVSEALYRAGIDPRRLAGAVTAPEVAALVGHVRAVLEEAIAAGGSSLRDHRQATGELGYF
HHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHH
QHSFRVYGREGAPCPTPGCTGTVQRIVQSGRSSFFCPLCQQ
HHEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA