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The map label for this gene is metA

Identifier: 119387204

GI number: 119387204

Start: 1714056

End: 1714982

Strand: Direct

Name: metA

Synonym: Pden_4499

Alternate gene names: 119387204

Gene position: 1714056-1714982 (Clockwise)

Preceding gene: 119387203

Following gene: 119387205

Centisome position: 99.07

GC content: 63.65

Gene sequence:

>927_bases
ATGCCCATCACCCTGCCCAATGACCTGCCCGCCTATGACATCCTGTCGAACGAAGGCGTCATGGTCATGTCGCCGGGCCG
GGCGGCGACGCAGGACATCCGGCCGCTGCGCATCGGGCTGCTGAACCTGATGCCCAAGAAGATCCAGACCGAGAACCAGT
TCGCCCGGCTGATCGGCGCCACGCCCCTGCAGATCGACTTCCAGCTGATCCGCATGTCGGACCACGAAAGCCGCAACACG
GCGGCCGATCACCTGCAATCCTTCTACCGCCGCTTCTGCGAGGTCGAGGAGACGGGCGAGAAGTTCGACGGTCTCATCAT
CACCGGCGCGCCCATCGAGCACCTGCCCTTCGAAGAGGTGACCTATTGGGAGGAACTGACGCGGGTCTTTCGATGGACGC
AAAGCCATGTGCATTCGACCTTCGGCGTCTGCTGGGGCGGCATGGCGATGGCGTGGCATTTCCATCGCCTCGAAAAGCAC
ATGCTGGACCACAAGGCCTTCGGCTGCTTCCGCCACCGCAACCTGGTGCCGGCCAGCCCCTATCTGCGCGGCTTTTCCGA
CGACGTGCTGGTCCCGGTCAGCCGCTGGACCGAGGTGCGCCAGGACGAGGTGGATGCCATCCCGGCGCTGCAGACGCTGA
TCGCCTCGGACCAGGTCGGGCCGTGCCTGCTGCAGGACACGGGCCATCGCGCGCTCTATGTCTTCAACCATTTCGAATAT
GACAGCACGACGCTGAAGGACGAATACGACCGCGACGTGGTCTCGGGCAAGCCGATCAACGTGCCGGTGAACTACTACCC
GGACGACGATCCCTCGCGCGCGCCGACGAACCGCTGGCGCAGCCATGCGCATCTGCTCTACGGTAACTGGATCAACGAGA
TCTACCAGACCACCCATTTCGACCTGAACCGCATCGGCGAGGCGTAA

Upstream 100 bases:

>100_bases
TGACAAACCCGGCCGACCTGATCGCCCTGATCGGCCATGCCATCGAAAGACGGCCCGCCGGCGCAACCGCCGCCGGAAAG
ATCGACAGAAAGGACGCATG

Downstream 100 bases:

>100_bases
GCATGAGCAAGAACGGCAATGGCGGAAAGAACGGGACCAAGGGGGCGAAATCGCTGCCCGACCTGCCCTTTGTCGGCGCG
ATCACCCGCTATCTGGAAAA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGATPLQIDFQLIRMSDHESRNT
AADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEVTYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKH
MLDHKAFGCFRHRNLVPASPYLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEY
DSTTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHFDLNRIGEA

Sequences:

>Translated_308_residues
MPITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGATPLQIDFQLIRMSDHESRNT
AADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEVTYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKH
MLDHKAFGCFRHRNLVPASPYLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEY
DSTTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHFDLNRIGEA
>Mature_307_residues
PITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGATPLQIDFQLIRMSDHESRNTA
ADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEVTYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKHM
LDHKAFGCFRHRNLVPASPYLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEYD
STTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHFDLNRIGEA

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=307, Percent_Identity=41.3680781758958, Blast_Score=252, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_PARDP (A1BAL9)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_918259.1
- ProteinModelPortal:   A1BAL9
- SMR:   A1BAL9
- STRING:   A1BAL9
- GeneID:   4583049
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_4499
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   A1BAL9
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35552; Mature: 35420

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGA
CCCCCCCCCCCHHEECCCCEEEECCCCHHHHCCCHHHHHHHHHCHHHHCCHHHHHHHHCC
TPLQIDFQLIRMSDHESRNTAADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEV
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCCHHHH
TYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKHMLDHKAFGCFRHRNLVPASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEY
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECC
DSTTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHF
CCCCCCCHHCCHHHCCCCEEECEECCCCCCCCCCCHHHHHHHHHEEHHHHHHHHHHHHCC
DLNRIGEA
CHHHCCCC
>Mature Secondary Structure 
PITLPNDLPAYDILSNEGVMVMSPGRAATQDIRPLRIGLLNLMPKKIQTENQFARLIGA
CCCCCCCCCCHHEECCCCEEEECCCCHHHHCCCHHHHHHHHHCHHHHCCHHHHHHHHCC
TPLQIDFQLIRMSDHESRNTAADHLQSFYRRFCEVEETGEKFDGLIITGAPIEHLPFEEV
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCCHHHH
TYWEELTRVFRWTQSHVHSTFGVCWGGMAMAWHFHRLEKHMLDHKAFGCFRHRNLVPASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YLRGFSDDVLVPVSRWTEVRQDEVDAIPALQTLIASDQVGPCLLQDTGHRALYVFNHFEY
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECC
DSTTLKDEYDRDVVSGKPINVPVNYYPDDDPSRAPTNRWRSHAHLLYGNWINEIYQTTHF
CCCCCCCHHCCHHHCCCCEEECEECCCCCCCCCCCHHHHHHHHHEEHHHHHHHHHHHHCC
DLNRIGEA
CHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA