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The map label for this gene is cobW [H]

Identifier: 119386993

GI number: 119386993

Start: 1463935

End: 1464846

Strand: Direct

Name: cobW [H]

Synonym: Pden_4288

Alternate gene names: 119386993

Gene position: 1463935-1464846 (Clockwise)

Preceding gene: 119386992

Following gene: 119386994

Centisome position: 84.62

GC content: 69.85

Gene sequence:

>912_bases
ATGGCCGCCCCGCTTCCGGTCAACATCCTGTGCGGCTATCTGGGGGCCGGCAAGACCACCTTGCTCAACCGGCTCCTGGA
GCGGCAGGACGAGCGCATCCTGGTCATGGTCAACGATTTCGGCGACATCGCGGTCGATGCGGCGCTGGTCTCGCGCCGCT
CGGCCGACACGATCCAGCTCAGCAACGGCTGCATCTGCTGTTCCATGGCGGGTGGGCTGTTCGATGCCTTCGAGCGGGCG
CTGGACCTTCGCGGCCGGGTCGATCGCCTGATCGTCGAGGCCAGCGGCGTCGCCGAGCCCCGGCGGCTGGCAGGCATCGC
CCTGGCCGAGCCCGACCTGGATTGTCGGGCAATCGTCGCCGTGGCCGATCCGCAAAGCCTGGCCGAACGCCTGGCCGACC
CGAGGATCGGCGGCGTGGCGGAAAGCCAGGTCCGGGGCGCGGATATGGTGTTCCTGTCGCGCGGCGACATCGCCAGCCGC
GCCGCGCTGCGCCGCACCGCCCGGCTGGTCGCCGGGATCAATCCGCTGGCCAGCCTGCACATGGCCCTGGACAGCGGTCT
GCTGAAGGCGCTGAGGGCACCCCACGACGCCCGAAGCTTTTCGGCCCTTGCCCCGCATCGCGACCACCGGCACCTGTTCG
CCAGCCGCACCATCACGCTTGCATCGCCGCCGGATCGTCAGCGCCTGCTCGGAATCATGGCGCGCCATACGCAGTCGATC
CATCGCCTGAAGGGGTATGTCCGCCTGCCCGATCTGCCCCGGCCCCATCTGCTGCAACTGGCCGGGGGCATGCTGTCCCT
GGAACCGGCCGAGGCGCCCGACGCCCCGTTCCTGAACCGCCTGGTTGCCATTTCGCCGGACAAGCATGCGCTGGTGAACC
TGGTGGCCGAGTTGGAGCAGGTGCGGGCCTGA

Upstream 100 bases:

>100_bases
GGACGACCCGCACGCGCTTGGCCCCGAACGTCTGCGCGAGGCGCGGGTCTGGGGCACCGTCTTCGGCGGCCGGCCGGTCC
CGGCCGGATCGTTCTAAGCC

Downstream 100 bases:

>100_bases
AATACCCGTCCCCGAACGGCTGCAAGCTTGGCCGAAACCCGAATCGGCATGGAGAGCCGATCCGCGGCCCGACGCGACCG
GCCGGGCGGGATGACCGCCT

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MAAPLPVNILCGYLGAGKTTLLNRLLERQDERILVMVNDFGDIAVDAALVSRRSADTIQLSNGCICCSMAGGLFDAFERA
LDLRGRVDRLIVEASGVAEPRRLAGIALAEPDLDCRAIVAVADPQSLAERLADPRIGGVAESQVRGADMVFLSRGDIASR
AALRRTARLVAGINPLASLHMALDSGLLKALRAPHDARSFSALAPHRDHRHLFASRTITLASPPDRQRLLGIMARHTQSI
HRLKGYVRLPDLPRPHLLQLAGGMLSLEPAEAPDAPFLNRLVAISPDKHALVNLVAELEQVRA

Sequences:

>Translated_303_residues
MAAPLPVNILCGYLGAGKTTLLNRLLERQDERILVMVNDFGDIAVDAALVSRRSADTIQLSNGCICCSMAGGLFDAFERA
LDLRGRVDRLIVEASGVAEPRRLAGIALAEPDLDCRAIVAVADPQSLAERLADPRIGGVAESQVRGADMVFLSRGDIASR
AALRRTARLVAGINPLASLHMALDSGLLKALRAPHDARSFSALAPHRDHRHLFASRTITLASPPDRQRLLGIMARHTQSI
HRLKGYVRLPDLPRPHLLQLAGGMLSLEPAEAPDAPFLNRLVAISPDKHALVNLVAELEQVRA
>Mature_302_residues
AAPLPVNILCGYLGAGKTTLLNRLLERQDERILVMVNDFGDIAVDAALVSRRSADTIQLSNGCICCSMAGGLFDAFERAL
DLRGRVDRLIVEASGVAEPRRLAGIALAEPDLDCRAIVAVADPQSLAERLADPRIGGVAESQVRGADMVFLSRGDIASRA
ALRRTARLVAGINPLASLHMALDSGLLKALRAPHDARSFSALAPHRDHRHLFASRTITLASPPDRQRLLGIMARHTQSIH
RLKGYVRLPDLPRPHLLQLAGGMLSLEPAEAPDAPFLNRLVAISPDKHALVNLVAELEQVRA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI223941779, Length=335, Percent_Identity=25.3731343283582, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI33469141, Length=321, Percent_Identity=25.5451713395639, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI126722884, Length=345, Percent_Identity=24.6376811594203, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI148727351, Length=345, Percent_Identity=24.6376811594203, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI146231952, Length=345, Percent_Identity=24.6376811594203, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI119120938, Length=324, Percent_Identity=24.6913580246914, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI223941776, Length=331, Percent_Identity=23.5649546827795, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87082430, Length=196, Percent_Identity=33.1632653061224, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788499, Length=232, Percent_Identity=29.3103448275862, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324356, Length=202, Percent_Identity=27.2277227722772, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 32649; Mature: 32518

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPLPVNILCGYLGAGKTTLLNRLLERQDERILVMVNDFGDIAVDAALVSRRSADTIQL
CCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEE
SNGCICCSMAGGLFDAFERALDLRGRVDRLIVEASGVAEPRRLAGIALAEPDLDCRAIVA
CCCEEEEEHHHHHHHHHHHHHHHHCHHHHHEEECCCCCCCHHHCEEEECCCCCCCEEEEE
VADPQSLAERLADPRIGGVAESQVRGADMVFLSRGDIASRAALRRTARLVAGINPLASLH
ECCHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
MALDSGLLKALRAPHDARSFSALAPHRDHRHLFASRTITLASPPDRQRLLGIMARHTQSI
HHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHH
HRLKGYVRLPDLPRPHLLQLAGGMLSLEPAEAPDAPFLNRLVAISPDKHALVNLVAELEQ
HHHHCCEECCCCCCHHHHHHCCCCEEECCCCCCCCHHHHHEEEECCCHHHHHHHHHHHHH
VRA
HCC
>Mature Secondary Structure 
AAPLPVNILCGYLGAGKTTLLNRLLERQDERILVMVNDFGDIAVDAALVSRRSADTIQL
CCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEE
SNGCICCSMAGGLFDAFERALDLRGRVDRLIVEASGVAEPRRLAGIALAEPDLDCRAIVA
CCCEEEEEHHHHHHHHHHHHHHHHCHHHHHEEECCCCCCCHHHCEEEECCCCCCCEEEEE
VADPQSLAERLADPRIGGVAESQVRGADMVFLSRGDIASRAALRRTARLVAGINPLASLH
ECCHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
MALDSGLLKALRAPHDARSFSALAPHRDHRHLFASRTITLASPPDRQRLLGIMARHTQSI
HHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHH
HRLKGYVRLPDLPRPHLLQLAGGMLSLEPAEAPDAPFLNRLVAISPDKHALVNLVAELEQ
HHHHCCEECCCCCCHHHHHHCCCCEEECCCCCCCCHHHHHEEEECCCHHHHHHHHHHHHH
VRA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]