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The map label for this gene is hmuU [H]

Identifier: 119386909

GI number: 119386909

Start: 1364245

End: 1365321

Strand: Direct

Name: hmuU [H]

Synonym: Pden_4204

Alternate gene names: 119386909

Gene position: 1364245-1365321 (Clockwise)

Preceding gene: 119386908

Following gene: 119386910

Centisome position: 78.85

GC content: 72.52

Gene sequence:

>1077_bases
ATGGTGGCCGTGACGCCCGACCTTCGCCCCGAACGGCTGGAAGGGGACCGCAGCCACCGCGCCCGGCGCCTGGGCCTGTT
CCTGGCGCTGCTGCTGGCCGTGGTGGCGGTGATCTCGCTGGGCTGGGGGGCCTCGGGGACGTCGCTCACGCGGGCGGTCT
CGGACCTGATGGCGGGGCGCGAGCTTGCGGTGCAGGACCGGGTGGTGCTGATGGACATCCGCCTGCCGCGCGTGCTGATG
GGCATCTTCGTCGGTGCCTCGCTGGCGGTCTCGGGCGCGGTGATGCAGGGGCTGTTTCGCAACCCGCTGGCCGATCCGGG
CATCGTCGGCGTCAGCTCGGGCGCCTCGCTGGGCGCGATCCTGGCCATCGTGCTGGGCAGCGCGCTGCCCGCCGGGATCG
CGGCGTTCTTCGGCTGGTATCTGGTGCCCGTCGCGGCCTTTGCCGGCGGCTGGCTGACCACCATCGCGCTTTACCGCATC
GCCACGCGGCGCGGGCGCACCTCGGTCGCGACCATGCTGCTGGCCGGCATCGCGCTGGCCGCGATCATGGGGGCGCTTTC
GGGCGTGGTGATCCTGCGCGCCAGTGACCGGGAATTGCGCGACCTGACCTTCTGGGGGCTGGGCTCGCTTGCCGGGGCGA
ACTGGCCCAAGCTGCTGGCCGGGGCGCCGATCATGGCGCTGGCGCTGCTTTACGCCCCCTGGCTGGCGCGCGGTCTGAAC
GCGCTGGCGCTGGGAGAGGCGGCAGCCGGCCATGTCGGCATCCGGGTGCAAAAGGTCAAGAACCGCGCCATCCTGACCGT
CGCCGCCGCCACCGGCGCCGCCGTTGCGGTCTCGGGCGGCATCGGCTTCGTCGGCATCGTCGTGCCGCACCTCTTGCGGC
TGGCCAGCGGGCCGGACCACCGCTGGCTGCTGGTCAACTCGGCGCTTCTGGGCGCGGTGACGCTGCTGCTGGCCGACATG
GTCAGCCGCACCGTCATCGCCCCGGCCGAACTGCCGATCGGCATCGTCACCGCCATCATGGGCGGGCCCTTCTTCCTGTG
GATCCTGCTGCGCAACCGGGGGGTGCTGGACCTGTGA

Upstream 100 bases:

>100_bases
GCCGGCTGGTGATGATGGACGGGCTGAAACTGCTGGGCTTCGGCCCCCGCACCGGCGAAGCCGCGGTCGAGCTGCACGAC
CTGATCTATACGGGGTCGTG

Downstream 100 bases:

>100_bases
GCCTGATCGCCACCGACATCCGGGTCAGCCTTGGCCGCAAGGAAATCCTGCACGCCGTCTCGGTCGAGGCGCGCGCGGGC
GAGATCACCGCCATCGTCGG

Product: transport system permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVAVTPDLRPERLEGDRSHRARRLGLFLALLLAVVAVISLGWGASGTSLTRAVSDLMAGRELAVQDRVVLMDIRLPRVLM
GIFVGASLAVSGAVMQGLFRNPLADPGIVGVSSGASLGAILAIVLGSALPAGIAAFFGWYLVPVAAFAGGWLTTIALYRI
ATRRGRTSVATMLLAGIALAAIMGALSGVVILRASDRELRDLTFWGLGSLAGANWPKLLAGAPIMALALLYAPWLARGLN
ALALGEAAAGHVGIRVQKVKNRAILTVAAATGAAVAVSGGIGFVGIVVPHLLRLASGPDHRWLLVNSALLGAVTLLLADM
VSRTVIAPAELPIGIVTAIMGGPFFLWILLRNRGVLDL

Sequences:

>Translated_358_residues
MVAVTPDLRPERLEGDRSHRARRLGLFLALLLAVVAVISLGWGASGTSLTRAVSDLMAGRELAVQDRVVLMDIRLPRVLM
GIFVGASLAVSGAVMQGLFRNPLADPGIVGVSSGASLGAILAIVLGSALPAGIAAFFGWYLVPVAAFAGGWLTTIALYRI
ATRRGRTSVATMLLAGIALAAIMGALSGVVILRASDRELRDLTFWGLGSLAGANWPKLLAGAPIMALALLYAPWLARGLN
ALALGEAAAGHVGIRVQKVKNRAILTVAAATGAAVAVSGGIGFVGIVVPHLLRLASGPDHRWLLVNSALLGAVTLLLADM
VSRTVIAPAELPIGIVTAIMGGPFFLWILLRNRGVLDL
>Mature_358_residues
MVAVTPDLRPERLEGDRSHRARRLGLFLALLLAVVAVISLGWGASGTSLTRAVSDLMAGRELAVQDRVVLMDIRLPRVLM
GIFVGASLAVSGAVMQGLFRNPLADPGIVGVSSGASLGAILAIVLGSALPAGIAAFFGWYLVPVAAFAGGWLTTIALYRI
ATRRGRTSVATMLLAGIALAAIMGALSGVVILRASDRELRDLTFWGLGSLAGANWPKLLAGAPIMALALLYAPWLARGLN
ALALGEAAAGHVGIRVQKVKNRAILTVAAATGAAVAVSGGIGFVGIVVPHLLRLASGPDHRWLLVNSALLGAVTLLLADM
VSRTVIAPAELPIGIVTAIMGGPFFLWILLRNRGVLDL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=330, Percent_Identity=38.7878787878788, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1788004, Length=297, Percent_Identity=42.4242424242424, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1790741, Length=316, Percent_Identity=36.0759493670886, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786804, Length=338, Percent_Identity=33.7278106508876, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786805, Length=300, Percent_Identity=38, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786347, Length=352, Percent_Identity=32.1022727272727, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37006; Mature: 37006

Theoretical pI: Translated: 11.98; Mature: 11.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVTPDLRPERLEGDRSHRARRLGLFLALLLAVVAVISLGWGASGTSLTRAVSDLMAGR
CEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
ELAVQDRVVLMDIRLPRVLMGIFVGASLAVSGAVMQGLFRNPLADPGIVGVSSGASLGAI
HHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHH
LAIVLGSALPAGIAAFFGWYLVPVAAFAGGWLTTIALYRIATRRGRTSVATMLLAGIALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AIMGALSGVVILRASDRELRDLTFWGLGSLAGANWPKLLAGAPIMALALLYAPWLARGLN
HHHHHHCCEEEEEECCCHHHHHHHHCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCC
ALALGEAAAGHVGIRVQKVKNRAILTVAAATGAAVAVSGGIGFVGIVVPHLLRLASGPDH
HHHHCCHHCCCCCEEEEEECCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
RWLLVNSALLGAVTLLLADMVSRTVIAPAELPIGIVTAIMGGPFFLWILLRNRGVLDL
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAVTPDLRPERLEGDRSHRARRLGLFLALLLAVVAVISLGWGASGTSLTRAVSDLMAGR
CEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
ELAVQDRVVLMDIRLPRVLMGIFVGASLAVSGAVMQGLFRNPLADPGIVGVSSGASLGAI
HHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHH
LAIVLGSALPAGIAAFFGWYLVPVAAFAGGWLTTIALYRIATRRGRTSVATMLLAGIALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AIMGALSGVVILRASDRELRDLTFWGLGSLAGANWPKLLAGAPIMALALLYAPWLARGLN
HHHHHHCCEEEEEECCCHHHHHHHHCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCC
ALALGEAAAGHVGIRVQKVKNRAILTVAAATGAAVAVSGGIGFVGIVVPHLLRLASGPDH
HHHHCCHHCCCCCEEEEEECCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
RWLLVNSALLGAVTLLLADMVSRTVIAPAELPIGIVTAIMGGPFFLWILLRNRGVLDL
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]