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The map label for this gene is ccmE

Identifier: 119386681

GI number: 119386681

Start: 1113790

End: 1114233

Strand: Direct

Name: ccmE

Synonym: Pden_3974

Alternate gene names: 119386681

Gene position: 1113790-1114233 (Clockwise)

Preceding gene: 119386680

Following gene: 119386682

Centisome position: 64.38

GC content: 64.41

Gene sequence:

>444_bases
ATGAAGTCTTTGAAGAAAAAGCGCCGTATCCAGATCCTCGTCGCCGCTGCCGTGGCCCTTGTCCTGGCCGTCGGGCTGAT
CGGCTATGGATTTCGCGACGGCATCAACCTGTATCGCTCGCCCAGCCAGATGGCCGAGAACCCGCCCGAGGCCGGCGAGG
TCTTTCGCCTTGGCGGGCTGGTCGAGGATGGCAGCCTGGTGCGCGGCGCCAGCGAGACGGTGACTTTTCGCGTGACCGAC
GGCGGCGCCACCGTCCCGGTGCGCTTTACCGGCGTGCTGCCCGACCTTTTCTCCGAGGGCCAGGGCATGATCGGCACCGG
GCGGATGGAGGGCGAAACCTTCGTTGCCTCCGAGATCCTGGCCAAGCACGACGAGAATTACATGCCGCGCGAGGTCATGG
ATTCGCTCAAGGAGCAGGGCGTCTATCAGGAGCCGAATTCCTGA

Upstream 100 bases:

>100_bases
CCTGACCACCGGCGATCCTGAGCGGGTCTCGGGCAAGGCCACTCAATTCCTCCGCCATCCGATCAGGTTCGAAAGCGCCT
GAAGCAGGAAAGCTTGCACC

Downstream 100 bases:

>100_bases
CGCAACGCACGCCCGGTTAACGGCCGGTTAACCGGATTTCTCCAGCCTCGGTCCGCTTCAGGATTGGGGGCTGGAATGAA
GACAGTGACGCAGATCGCGG

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGLVEDGSLVRGASETVTFRVTD
GGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEILAKHDENYMPREVMDSLKEQGVYQEPNS

Sequences:

>Translated_147_residues
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGLVEDGSLVRGASETVTFRVTD
GGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEILAKHDENYMPREVMDSLKEQGVYQEPNS
>Mature_147_residues
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGLVEDGSLVRGASETVTFRVTD
GGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEILAKHDENYMPREVMDSLKEQGVYQEPNS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=158, Percent_Identity=37.9746835443038, Blast_Score=108, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_PARDP (A1B946)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917736.1
- ProteinModelPortal:   A1B946
- SMR:   A1B946
- STRING:   A1B946
- GeneID:   4582525
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3974
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   ICFCSAC
- PhylomeDB:   A1B946
- ProtClustDB:   PRK13254
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15892; Mature: 15892

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0x16686660)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHCCCHHHHCCCCCCCCEEHCCCC
VEDGSLVRGASETVTFRVTDGGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEIL
CCCCCEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHCCCCCEECCCCCCCHHHHHHHH
AKHDENYMPREVMDSLKEQGVYQEPNS
HHCCCCCCCHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHCCCHHHHCCCCCCCCEEHCCCC
VEDGSLVRGASETVTFRVTDGGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEIL
CCCCCEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHCCCCCEECCCCCCCHHHHHHHH
AKHDENYMPREVMDSLKEQGVYQEPNS
HHCCCCCCCHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA