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The map label for this gene is degQ [H]

Identifier: 119385870

GI number: 119385870

Start: 325116

End: 326492

Strand: Direct

Name: degQ [H]

Synonym: Pden_3148

Alternate gene names: 119385870

Gene position: 325116-326492 (Clockwise)

Preceding gene: 119385869

Following gene: 119385873

Centisome position: 18.79

GC content: 69.57

Gene sequence:

>1377_bases
ATGTCGATGAAAATCCCCCGACTGCGCGCGGCCGTCATCACGCTGTGCACGATCCTGGCGCTGGTCGCGCCGCCCCAAGC
GGCTGTCGGGCAGCCCATGCCCGAGGCTGGGGGCGGTATTCCCACCATTGCCCCGATGCTGTCGCGCGTGACCCCGGCGG
TGGTCAATATCGCGGTGGTCTCGGAAACCCCGGTAGTATCGAACCCGCTTTACAACGATCCCTATTTCCGCCGCTTCTTC
GATCTTCGCGACCCGCCGATGCGGCGGCAGATGAGCGCCGGCTCCGGCGTGATCGTCGATGCCGAAAACGGCTATGTGCT
GACCAACCATCACGTCGTCGCCGAGGCCAGCGCGATCAGCGTCACCCTGAAGGACGGGCGCCAGTTCCGGGCCGAGCTCG
TCGGCGCCGACCAGGCCACGGAAATCGCCCTGCTGCGGATCGAGGCCGAGGATCTGGTCGCGCTGGAGATCGGCGATTCC
GACCGCCTTCAGGTCGGCGATTTCGTCGCCGCCATCGGCAACCCCTTCGGCCTGGGCCAGACGGTGACCTCGGGCATCGT
CAGCGCGCTGGGGCGCAGCGGCATCAGCCGCGAGGGCTATGAGGATTTCATCCAGACCGACGCCTCGATCAACCCGGGCA
ATTCGGGCGGCGCGCTGGTGACGCTGGACGGCCGGCTGGTCGGCATCAACACCGCCATCCTGACCCCGGCAGGGGGCAAT
ATCGGCATCGGCTTCGCGGTGCCCAGCAACATGGCCGTCGCGGTGATGCGGCAGCTGATCGAGCACGGCGAGGTGCGGCG
CGGCAGGCTGGGCATCGGCATGCACGATCTGACGCCCGACCTGGCCGAGGCGCTGGAGCTGGGCGGCATCCACGGCGCGG
TGATCGCGAATGTCGAGCCCGGCTCTCCCGCCGAGAAGGCGGGGCTGAAGGCGGGGGACGTGGTGACCGCTGTCGACGGC
GCCCCGGTGCAGGGCGCCACGCATCTGCGAAACCGGCTGGGCCTGACGCCCGTCGGCAGCACCATCCGCCTGACGGTCAG
GCGCGAGGGGGATGCGCGGGAGGTCGACCTGACCATCACCGCCGATGCGACCTCCTCCGGTGATTTCGCCGGCACGCCGC
TGGATGGCGCCCGGCTGCGCAACGCCTCGGCGGAGGAGGCGCGCCGGGCGGGGGGTGCCGGGATCATGGTCGACAGCGTC
GAGCCGGACAGCCTTGCGGCCTGGATCGGCCTGCGCCGCGGCGACATGATCGTCGCCGTCAACCGGACGCCGGTTTCCTC
GGTCGCGGATTTGCGTGACATGCTTGCCGGCCACCGAGCCGTCGCGGCGCTGGAACTGATCCGCGACGGCAGCCGTCTTT
TCATCGTCGCAAGGTGA

Upstream 100 bases:

>100_bases
GACGTCCCGAACGGCCCGGCAACCCGCCGGGCCGTTTTCTTGTTCTCCGTCTGGTCTCGGGCGAGAAAGGAAATCACCAC
CGATCAAACGGAGATTGCCG

Downstream 100 bases:

>100_bases
ACGACGGCGGCGGCATGGAGAGGGCCAGGAAGACGCAGGGTGTCGTCACCGATGCCTGGGCGTCGCTCATCTGACGCAGC
CCCGGACCTTGCCGGTTTCA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSMKIPRLRAAVITLCTILALVAPPQAAVGQPMPEAGGGIPTIAPMLSRVTPAVVNIAVVSETPVVSNPLYNDPYFRRFF
DLRDPPMRRQMSAGSGVIVDAENGYVLTNHHVVAEASAISVTLKDGRQFRAELVGADQATEIALLRIEAEDLVALEIGDS
DRLQVGDFVAAIGNPFGLGQTVTSGIVSALGRSGISREGYEDFIQTDASINPGNSGGALVTLDGRLVGINTAILTPAGGN
IGIGFAVPSNMAVAVMRQLIEHGEVRRGRLGIGMHDLTPDLAEALELGGIHGAVIANVEPGSPAEKAGLKAGDVVTAVDG
APVQGATHLRNRLGLTPVGSTIRLTVRREGDAREVDLTITADATSSGDFAGTPLDGARLRNASAEEARRAGGAGIMVDSV
EPDSLAAWIGLRRGDMIVAVNRTPVSSVADLRDMLAGHRAVAALELIRDGSRLFIVAR

Sequences:

>Translated_458_residues
MSMKIPRLRAAVITLCTILALVAPPQAAVGQPMPEAGGGIPTIAPMLSRVTPAVVNIAVVSETPVVSNPLYNDPYFRRFF
DLRDPPMRRQMSAGSGVIVDAENGYVLTNHHVVAEASAISVTLKDGRQFRAELVGADQATEIALLRIEAEDLVALEIGDS
DRLQVGDFVAAIGNPFGLGQTVTSGIVSALGRSGISREGYEDFIQTDASINPGNSGGALVTLDGRLVGINTAILTPAGGN
IGIGFAVPSNMAVAVMRQLIEHGEVRRGRLGIGMHDLTPDLAEALELGGIHGAVIANVEPGSPAEKAGLKAGDVVTAVDG
APVQGATHLRNRLGLTPVGSTIRLTVRREGDAREVDLTITADATSSGDFAGTPLDGARLRNASAEEARRAGGAGIMVDSV
EPDSLAAWIGLRRGDMIVAVNRTPVSSVADLRDMLAGHRAVAALELIRDGSRLFIVAR
>Mature_457_residues
SMKIPRLRAAVITLCTILALVAPPQAAVGQPMPEAGGGIPTIAPMLSRVTPAVVNIAVVSETPVVSNPLYNDPYFRRFFD
LRDPPMRRQMSAGSGVIVDAENGYVLTNHHVVAEASAISVTLKDGRQFRAELVGADQATEIALLRIEAEDLVALEIGDSD
RLQVGDFVAAIGNPFGLGQTVTSGIVSALGRSGISREGYEDFIQTDASINPGNSGGALVTLDGRLVGINTAILTPAGGNI
GIGFAVPSNMAVAVMRQLIEHGEVRRGRLGIGMHDLTPDLAEALELGGIHGAVIANVEPGSPAEKAGLKAGDVVTAVDGA
PVQGATHLRNRLGLTPVGSTIRLTVRREGDAREVDLTITADATSSGDFAGTPLDGARLRNASAEEARRAGGAGIMVDSVE
PDSLAAWIGLRRGDMIVAVNRTPVSSVADLRDMLAGHRAVAALELIRDGSRLFIVAR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=36.4485981308411, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22129776, Length=327, Percent_Identity=34.5565749235474, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7019477, Length=305, Percent_Identity=36.3934426229508, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=35.2, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1789629, Length=424, Percent_Identity=46.4622641509434, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1786356, Length=452, Percent_Identity=43.8053097345133, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1789630, Length=318, Percent_Identity=40.5660377358491, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=34.0909090909091, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47616; Mature: 47485

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMKIPRLRAAVITLCTILALVAPPQAAVGQPMPEAGGGIPTIAPMLSRVTPAVVNIAVV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHCCHHHEEEEEE
SETPVVSNPLYNDPYFRRFFDLRDPPMRRQMSAGSGVIVDAENGYVLTNHHVVAEASAIS
ECCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCEEEECCEEEEECEEEE
VTLKDGRQFRAELVGADQATEIALLRIEAEDLVALEIGDSDRLQVGDFVAAIGNPFGLGQ
EEECCCHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCCEEHHHHHHHHCCCCCCCH
TVTSGIVSALGRSGISREGYEDFIQTDASINPGNSGGALVTLDGRLVGINTAILTPAGGN
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCC
IGIGFAVPSNMAVAVMRQLIEHGEVRRGRLGIGMHDLTPDLAEALELGGIHGAVIANVEP
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCC
GSPAEKAGLKAGDVVTAVDGAPVQGATHLRNRLGLTPVGSTIRLTVRREGDAREVDLTIT
CCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEEEE
ADATSSGDFAGTPLDGARLRNASAEEARRAGGAGIMVDSVEPDSLAAWIGLRRGDMIVAV
ECCCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCEEEEECCCCHHHHHHHEECCCCEEEEE
NRTPVSSVADLRDMLAGHRAVAALELIRDGSRLFIVAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure 
SMKIPRLRAAVITLCTILALVAPPQAAVGQPMPEAGGGIPTIAPMLSRVTPAVVNIAVV
CCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHCCHHHEEEEEE
SETPVVSNPLYNDPYFRRFFDLRDPPMRRQMSAGSGVIVDAENGYVLTNHHVVAEASAIS
ECCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCEEEECCEEEEECEEEE
VTLKDGRQFRAELVGADQATEIALLRIEAEDLVALEIGDSDRLQVGDFVAAIGNPFGLGQ
EEECCCHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCCEEHHHHHHHHCCCCCCCH
TVTSGIVSALGRSGISREGYEDFIQTDASINPGNSGGALVTLDGRLVGINTAILTPAGGN
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCC
IGIGFAVPSNMAVAVMRQLIEHGEVRRGRLGIGMHDLTPDLAEALELGGIHGAVIANVEP
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCC
GSPAEKAGLKAGDVVTAVDGAPVQGATHLRNRLGLTPVGSTIRLTVRREGDAREVDLTIT
CCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEEEE
ADATSSGDFAGTPLDGARLRNASAEEARRAGGAGIMVDSVEPDSLAAWIGLRRGDMIVAV
ECCCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCEEEEECCCCHHHHHHHEECCCCEEEEE
NRTPVSSVADLRDMLAGHRAVAALELIRDGSRLFIVAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]