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The map label for this gene is pdhR [H]

Identifier: 119385654

GI number: 119385654

Start: 92529

End: 93302

Strand: Direct

Name: pdhR [H]

Synonym: Pden_2929

Alternate gene names: 119385654

Gene position: 92529-93302 (Clockwise)

Preceding gene: 119385646

Following gene: 119385655

Centisome position: 5.35

GC content: 70.41

Gene sequence:

>774_bases
ATGCCCAGCGAAGTGAACAAGGGAGCCCCTGCCGCGGAAACCACCGCCCGGCACATCGAGGACCTGATTCTCGAAGGCTC
GCTGCGCCCCGGCGACCCCTTGCTGCCCGAGCGCGAGATGGCGCTGCGGCTGAACGTCTCGCGCCCGACCTTGCGGCAGG
GCATCCGCATGCTGGAGGAGAGGGGGCTGATCGTCGCCGATCCGGGCGGCGGGCGGCGGGTGGCGCCGCTGGCCACCAGC
ATCACCGATCCGCTGATCGAGCTGATGGCCTCGCGCGGGGAGGTGGTGGACGACTATCTGGAACTGCGCGGCACGCTGGA
GGGCATGGCGGCGAGCCTGGCCGCGACGCGGGCGAGCGACGTGGACCGCGCGACGCTGACCCGCTGCATGGAGCGCATCG
ACCTGGCCCATGACGAGGCGGATTTCCGCGACGAGGCCGAGGCGGATGTCGACCTGCATGTCGCGGTCTACGAGGCCAGC
CACAACGTCGTGCTGCTGCAGATCATGCGGGCGCTGTCGGGCATGCTGCGCAAGGGCGTGTTCCACAACCGCGAAAAGCT
GTATGCCCGGCCCGAGGTGCGCGACGTGCTGCGCGCCCAGCACCGCGCCATCTATGACGCGATCATGGTCCGCGACCCCG
AGGCGGCGGCCCGCGCCGCCCAGGACCACATGACCTATACCAAGCGCGTGCGCGCCGAGATCATTGCCGCCGAGGCGCGG
CTGGAAATCTCGTTGCGGCGGATCGAGGGCGGCAGCCTGACCGCGCGGAACTGA

Upstream 100 bases:

>100_bases
GAAAATCCATTGCGCCCGATCCGGGACTGCGGGTAATCTTTGGGACCGGGTGCCGCCGCCTAACCCCCTGAATTTCCGGC
AGCCCCGCAAGGAGTCGAGC

Downstream 100 bases:

>100_bases
ACGGCTTTGCGGGTTCCGGCATCTGTGCCATCATGATTCCCCAGCAACCGCAGGGAGATGGCGCATGGACATGATGGACA
GGCTGGCCGCCCGGATCGAC

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MPSEVNKGAPAAETTARHIEDLILEGSLRPGDPLLPEREMALRLNVSRPTLRQGIRMLEERGLIVADPGGGRRVAPLATS
ITDPLIELMASRGEVVDDYLELRGTLEGMAASLAATRASDVDRATLTRCMERIDLAHDEADFRDEAEADVDLHVAVYEAS
HNVVLLQIMRALSGMLRKGVFHNREKLYARPEVRDVLRAQHRAIYDAIMVRDPEAAARAAQDHMTYTKRVRAEIIAAEAR
LEISLRRIEGGSLTARN

Sequences:

>Translated_257_residues
MPSEVNKGAPAAETTARHIEDLILEGSLRPGDPLLPEREMALRLNVSRPTLRQGIRMLEERGLIVADPGGGRRVAPLATS
ITDPLIELMASRGEVVDDYLELRGTLEGMAASLAATRASDVDRATLTRCMERIDLAHDEADFRDEAEADVDLHVAVYEAS
HNVVLLQIMRALSGMLRKGVFHNREKLYARPEVRDVLRAQHRAIYDAIMVRDPEAAARAAQDHMTYTKRVRAEIIAAEAR
LEISLRRIEGGSLTARN
>Mature_256_residues
PSEVNKGAPAAETTARHIEDLILEGSLRPGDPLLPEREMALRLNVSRPTLRQGIRMLEERGLIVADPGGGRRVAPLATSI
TDPLIELMASRGEVVDDYLELRGTLEGMAASLAATRASDVDRATLTRCMERIDLAHDEADFRDEAEADVDLHVAVYEASH
NVVLLQIMRALSGMLRKGVFHNREKLYARPEVRDVLRAQHRAIYDAIMVRDPEAAARAAQDHMTYTKRVRAEIIAAEARL
EISLRRIEGGSLTARN

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=220, Percent_Identity=40, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789353, Length=224, Percent_Identity=37.0535714285714, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790032, Length=210, Percent_Identity=36.1904761904762, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI48994961, Length=208, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790780, Length=238, Percent_Identity=27.3109243697479, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789621, Length=229, Percent_Identity=28.82096069869, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082208, Length=209, Percent_Identity=29.1866028708134, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI48994955, Length=227, Percent_Identity=30.3964757709251, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28473; Mature: 28342

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSEVNKGAPAAETTARHIEDLILEGSLRPGDPLLPEREMALRLNVSRPTLRQGIRMLEE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
RGLIVADPGGGRRVAPLATSITDPLIELMASRGEVVDDYLELRGTLEGMAASLAATRASD
CCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDRATLTRCMERIDLAHDEADFRDEAEADVDLHVAVYEASHNVVLLQIMRALSGMLRKGV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
FHNREKLYARPEVRDVLRAQHRAIYDAIMVRDPEAAARAAQDHMTYTKRVRAEIIAAEAR
HCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEISLRRIEGGSLTARN
HEEEEEEECCCCCCCCC
>Mature Secondary Structure 
PSEVNKGAPAAETTARHIEDLILEGSLRPGDPLLPEREMALRLNVSRPTLRQGIRMLEE
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
RGLIVADPGGGRRVAPLATSITDPLIELMASRGEVVDDYLELRGTLEGMAASLAATRASD
CCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDRATLTRCMERIDLAHDEADFRDEAEADVDLHVAVYEASHNVVLLQIMRALSGMLRKGV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
FHNREKLYARPEVRDVLRAQHRAIYDAIMVRDPEAAARAAQDHMTYTKRVRAEIIAAEAR
HCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEISLRRIEGGSLTARN
HEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]