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The map label for this gene is dnaA [H]

Identifier: 119385558

GI number: 119385558

Start: 405

End: 1751

Strand: Direct

Name: dnaA [H]

Synonym: Pden_2833

Alternate gene names: 119385558

Gene position: 405-1751 (Clockwise)

Preceding gene: NA

Following gene: 119385559

Centisome position: 0.02

GC content: 65.03

Gene sequence:

>1347_bases
ATGGACAGACTTTGGGGGCAGGCGCGTGAAGAACTTCAGAAAATCGTCGGAACCGACAGTTTCTCGACCTGGATCGAGCC
CCTTCGCCTGACCGGCGTTGCGGACGGCACCGCCACCATCGCCTGCCCGACCCGCTTCTTGTCCGACTGGGTCTCGCGCC
ATTACAGCGACGACATTCTCAAGGTGCTGGACCGGATGGGCGGCCCCGTGCAGCGCCTGAGCTTCGAGACCCGCAGCCAG
ACTGCCCGCCAGGCTGCGGCACCCGTCGTCAAGCGCCCCGCGCCCCCGCGCGTCTCTGGCGAGGAAGAGCTGGCGGCACC
GCTGGACAGCCGCTTCACCTTCGAGAATTTCGTGGTCGGCAAGCCGAACGAGCTGGCCCACGCCGCCGCCCGCCGCGTGG
CCGAGGGCGGGCCGGTTACCTTCAACCCGCTGTTCCTTTACGGCGGGGTCGGGCTGGGCAAGACCCACCTGATGCACGCC
ATCGCCCGCGAGATCCAGATCCGCCAACCCGAGGCGCGCGTGCTGTATCTTTCGGCCGAGCAGTTCATGTATCGCTTCGT
CCAGGCGCTGCGCGACCGCACCGTGATGGATTTCAAGGAGCTGTTCCGCACCGTCTCGGTGCTGATGGTCGATGACGTCC
AGTTCATCGCCGGCAAGGATTCCACGCAGGAGGAATTCTTCCACACTTTCAACACGCTGGTCGATCAGGGCAAGCAGATC
GTCATCTCGGCCGACCGCGCGCCGGGCGAGATCAAGGACATGGAAGAGCGTATCAAGTCGCGCCTGCAATGCGGCCTGGT
CGTGGACCTGCATCCGACCGATTACGAACTGCGCCTGGGCATCCTGCAAAGCAAGACCGACAGTTTCCGCGCGCAATATC
CGGGCCTGCTGATCGCGCCCGGGGTGCTGGAATTCCTGGCCCATCGCATCACCTCGAATGTCCGGGTGCTGGAAGGCGCG
CTGCAGCGGCTCTTCGCCTTTGCCAGCCTGATGGGGCGCGAGATCACGCTGGACATGACCCAGGAATGCCTGGCCGACAT
CCTGCGCGCCAACGACCGCAAGGTCTCGATCGAGGAGATCCAGCGGAAGGTGGCCGAGCATTACAACATCCGCCTGGCCG
ACATGATCGGACCCAAGCGCGTGCGCACCGTCGCCCGGCCGCGACAGATCGCCATGTATCTGGCCAAGCAGATGACCTCG
CGCAGCCTGCCCGAGATCGGGCGCCGCTTCGGCGGCCGCGATCACACCACCATCATGCATGGCGTGAAGAAGATCGAAGA
ACTACGCGGCTCGGATCGCAGCCTCTCCGAGGATATCGACCTGCTGCGCCGCCTGCTGGAGGCCTGA

Upstream 100 bases:

>100_bases
TCTGTTGCCGAAACTGCTGTCGTTCAGGCTGCGGCATCCGAATCGCCTCACGCCGGAAAATCCCGGCGGCATGTGGGGAA
AAGAGACGGAATTGGGCGAG

Downstream 100 bases:

>100_bases
ACGCATCCGCTTGACCTTGCGCGGGATTATGCCACATTGGCGCCCCGCGAGGCGGGTGCGAGACGAGGCCGGAACGACAT
AAGGGTTGACCATGAAATTC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MDRLWGQAREELQKIVGTDSFSTWIEPLRLTGVADGTATIACPTRFLSDWVSRHYSDDILKVLDRMGGPVQRLSFETRSQ
TARQAAAPVVKRPAPPRVSGEEELAAPLDSRFTFENFVVGKPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHA
IAREIQIRQPEARVLYLSAEQFMYRFVQALRDRTVMDFKELFRTVSVLMVDDVQFIAGKDSTQEEFFHTFNTLVDQGKQI
VISADRAPGEIKDMEERIKSRLQCGLVVDLHPTDYELRLGILQSKTDSFRAQYPGLLIAPGVLEFLAHRITSNVRVLEGA
LQRLFAFASLMGREITLDMTQECLADILRANDRKVSIEEIQRKVAEHYNIRLADMIGPKRVRTVARPRQIAMYLAKQMTS
RSLPEIGRRFGGRDHTTIMHGVKKIEELRGSDRSLSEDIDLLRRLLEA

Sequences:

>Translated_448_residues
MDRLWGQAREELQKIVGTDSFSTWIEPLRLTGVADGTATIACPTRFLSDWVSRHYSDDILKVLDRMGGPVQRLSFETRSQ
TARQAAAPVVKRPAPPRVSGEEELAAPLDSRFTFENFVVGKPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHA
IAREIQIRQPEARVLYLSAEQFMYRFVQALRDRTVMDFKELFRTVSVLMVDDVQFIAGKDSTQEEFFHTFNTLVDQGKQI
VISADRAPGEIKDMEERIKSRLQCGLVVDLHPTDYELRLGILQSKTDSFRAQYPGLLIAPGVLEFLAHRITSNVRVLEGA
LQRLFAFASLMGREITLDMTQECLADILRANDRKVSIEEIQRKVAEHYNIRLADMIGPKRVRTVARPRQIAMYLAKQMTS
RSLPEIGRRFGGRDHTTIMHGVKKIEELRGSDRSLSEDIDLLRRLLEA
>Mature_448_residues
MDRLWGQAREELQKIVGTDSFSTWIEPLRLTGVADGTATIACPTRFLSDWVSRHYSDDILKVLDRMGGPVQRLSFETRSQ
TARQAAAPVVKRPAPPRVSGEEELAAPLDSRFTFENFVVGKPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHA
IAREIQIRQPEARVLYLSAEQFMYRFVQALRDRTVMDFKELFRTVSVLMVDDVQFIAGKDSTQEEFFHTFNTLVDQGKQI
VISADRAPGEIKDMEERIKSRLQCGLVVDLHPTDYELRLGILQSKTDSFRAQYPGLLIAPGVLEFLAHRITSNVRVLEGA
LQRLFAFASLMGREITLDMTQECLADILRANDRKVSIEEIQRKVAEHYNIRLADMIGPKRVRTVARPRQIAMYLAKQMTS
RSLPEIGRRFGGRDHTTIMHGVKKIEELRGSDRSLSEDIDLLRRLLEA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=469, Percent_Identity=42.8571428571429, Blast_Score=381, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 50703; Mature: 50703

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLWGQAREELQKIVGTDSFSTWIEPLRLTGVADGTATIACPTRFLSDWVSRHYSDDIL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHCCHHHH
KVLDRMGGPVQRLSFETRSQTARQAAAPVVKRPAPPRVSGEEELAAPLDSRFTFENFVVG
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHCCCCCCCCCCCEECC
KPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAREIQIRQPEARVLYLSAE
CCHHHHHHHHHHHHCCCCEEECHHHEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHH
QFMYRFVQALRDRTVMDFKELFRTVSVLMVDDVQFIAGKDSTQEEFFHTFNTLVDQGKQI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHCCCEE
VISADRAPGEIKDMEERIKSRLQCGLVVDLHPTDYELRLGILQSKTDSFRAQYPGLLIAP
EEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHCCCHHHHHHCCCEEECH
GVLEFLAHRITSNVRVLEGALQRLFAFASLMGREITLDMTQECLADILRANDRKVSIEEI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEECHHHH
QRKVAEHYNIRLADMIGPKRVRTVARPRQIAMYLAKQMTSRSLPEIGRRFGGRDHTTIMH
HHHHHHHHCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
GVKKIEELRGSDRSLSEDIDLLRRLLEA
HHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRLWGQAREELQKIVGTDSFSTWIEPLRLTGVADGTATIACPTRFLSDWVSRHYSDDIL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHCCHHHH
KVLDRMGGPVQRLSFETRSQTARQAAAPVVKRPAPPRVSGEEELAAPLDSRFTFENFVVG
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHCCCCCCCCCCCEECC
KPNELAHAAARRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAREIQIRQPEARVLYLSAE
CCHHHHHHHHHHHHCCCCEEECHHHEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHH
QFMYRFVQALRDRTVMDFKELFRTVSVLMVDDVQFIAGKDSTQEEFFHTFNTLVDQGKQI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHCCCEE
VISADRAPGEIKDMEERIKSRLQCGLVVDLHPTDYELRLGILQSKTDSFRAQYPGLLIAP
EEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHCCCHHHHHHCCCEEECH
GVLEFLAHRITSNVRVLEGALQRLFAFASLMGREITLDMTQECLADILRANDRKVSIEEI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEECHHHH
QRKVAEHYNIRLADMIGPKRVRTVARPRQIAMYLAKQMTSRSLPEIGRRFGGRDHTTIMH
HHHHHHHHCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
GVKKIEELRGSDRSLSEDIDLLRRLLEA
HHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA