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The map label for this gene is murC

Identifier: 119358484

GI number: 119358484

Start: 3109613

End: 3111013

Strand: Reverse

Name: murC

Synonym: Cpha266_2720

Alternate gene names: 119358484

Gene position: 3111013-3109613 (Counterclockwise)

Preceding gene: 119358485

Following gene: 119358483

Centisome position: 99.27

GC content: 52.25

Gene sequence:

>1401_bases
ATGGAGCTCGGAAAAACAAAAAGTGTTCATATCGTAGGAATCGGCGGAGCGGGAATGAGCGCCATTGCCGAACTTCTGTT
AACCTCGGGTTTCGGGGTAACGGGCTCAGACCTCTCTTCAGGAGAGGTAACCGAGAGGCTCTCGGAACGGGGAGCTGTAA
TTTACCAGGGGCATAAAGCGGAACAGGTCGGAGAAAGCGACGTTGTCGTTTACTCCTCTGCTATCAGACCGGCAGAAAAC
GTCGAGATCGTTGCAGCCGAGCAGGCGGGTATTCCTGTGATCAAACGAGACGAGATGCTCGGAGAGCTCATGCGCTATAA
CTACGGGGTCTGCGTTTCCGGAACACACGGAAAGACAACCACAACGGCAATGATTGCCACCATGCTCATCGAAGCGGGTG
AGTCGCCGACGGTCATGATCGGCGGCGTTTCCGACTATCTCAAAGGGAGCACGGTCGTTGGCAGCGGCAAATACCTCGTT
ATTGAGGCTGACGAGTTTGATCGGGCGTTTTTAAAGCTGACACCAACAATCGCCGTGATCAACAGTCTTGAGTCAGAGCA
TATGGATACCTATGGGACGATAGAAGAGCTGCGTAAAGCCTTTATCGCTTTTGCCAACAAAGTGCCTTTTTACGGACGAG
TCATCTGCTGCGTCGACTGGCCGGAAATCAGGAAACTCATTCCGCATCTCAACCGTCGATACACCACCTTTGGCATTGAT
GAGCCGGCAGATGTGATGGCCTCGGATATGGTTATGGATAAAAACAGATCCCGTTTCACGGTGCGAGCTTCAGGCAAGGA
GTATCCCGGAGTCAGCCTCAATGTTCCTGGCCGGCATAACGTCATGAATGCGCTGGCGGCTTTCGCTTCCGGGCTTGAGC
TGGGAATTGCGCCCGAGCGCATTATCGCAGGCCTTACCCGGTACAGCGGCATGAGACGACGGTTTCAGATCAAGTATGAC
AATAGTGCTGGAGTTCTCGTCGTTGACGATTACGCCCACCATCCCTCAGAAGTCAAGGCTGCGGTAAAAGCAGCAAGAGA
TGGCTGGCCGAATGCAGAAATTGTCGCTGTTTTTCAGCCTCATCTTTTTTCAAGAACCAGAGAATTTGCGGATGAATATG
GTTGGGCGCTTCTTCGAGCCGATAAAATATATGTTGCCGACATCTATCCTTCCAGAGAAAAAGCGGCAGATTATCCCGGT
GTGAGCGGGAGTCTGGTTGCCGCGGCGGTACACAAGGCAGGGGGAAAGCATGCCGAATTTATAGCCGACAGGGAACTTTT
GTACCAAACGGTCGAAACATGCCCGCAAAAGAGTACGGTCGTACTGTTTATGGGGGCGGGGGATATTACCCATCTGTCTA
CAAGGCTTGCCGGGGAGTGGATCAATAAATTTTCAGCATGA

Upstream 100 bases:

>100_bases
CTCCGCCATGAGCAAGGCCGCTCTTTTGCTTGCTTATCCGGATGCGACGGCAGCGCTTGTTGACAGAATCATCCGCCTTG
CAAAATCATAAAGGAAAAAC

Downstream 100 bases:

>100_bases
TGGAGCAAAAGAGCAATGATTGCCGTTGAGGAGCATAAGCGCCCGATCAGCGGGAGAGTGATTCGTTTCGTACCACTTCG
TCCCCGCAGATCCGTCAGGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MELGKTKSVHIVGIGGAGMSAIAELLLTSGFGVTGSDLSSGEVTERLSERGAVIYQGHKAEQVGESDVVVYSSAIRPAEN
VEIVAAEQAGIPVIKRDEMLGELMRYNYGVCVSGTHGKTTTTAMIATMLIEAGESPTVMIGGVSDYLKGSTVVGSGKYLV
IEADEFDRAFLKLTPTIAVINSLESEHMDTYGTIEELRKAFIAFANKVPFYGRVICCVDWPEIRKLIPHLNRRYTTFGID
EPADVMASDMVMDKNRSRFTVRASGKEYPGVSLNVPGRHNVMNALAAFASGLELGIAPERIIAGLTRYSGMRRRFQIKYD
NSAGVLVVDDYAHHPSEVKAAVKAARDGWPNAEIVAVFQPHLFSRTREFADEYGWALLRADKIYVADIYPSREKAADYPG
VSGSLVAAAVHKAGGKHAEFIADRELLYQTVETCPQKSTVVLFMGAGDITHLSTRLAGEWINKFSA

Sequences:

>Translated_466_residues
MELGKTKSVHIVGIGGAGMSAIAELLLTSGFGVTGSDLSSGEVTERLSERGAVIYQGHKAEQVGESDVVVYSSAIRPAEN
VEIVAAEQAGIPVIKRDEMLGELMRYNYGVCVSGTHGKTTTTAMIATMLIEAGESPTVMIGGVSDYLKGSTVVGSGKYLV
IEADEFDRAFLKLTPTIAVINSLESEHMDTYGTIEELRKAFIAFANKVPFYGRVICCVDWPEIRKLIPHLNRRYTTFGID
EPADVMASDMVMDKNRSRFTVRASGKEYPGVSLNVPGRHNVMNALAAFASGLELGIAPERIIAGLTRYSGMRRRFQIKYD
NSAGVLVVDDYAHHPSEVKAAVKAARDGWPNAEIVAVFQPHLFSRTREFADEYGWALLRADKIYVADIYPSREKAADYPG
VSGSLVAAAVHKAGGKHAEFIADRELLYQTVETCPQKSTVVLFMGAGDITHLSTRLAGEWINKFSA
>Mature_466_residues
MELGKTKSVHIVGIGGAGMSAIAELLLTSGFGVTGSDLSSGEVTERLSERGAVIYQGHKAEQVGESDVVVYSSAIRPAEN
VEIVAAEQAGIPVIKRDEMLGELMRYNYGVCVSGTHGKTTTTAMIATMLIEAGESPTVMIGGVSDYLKGSTVVGSGKYLV
IEADEFDRAFLKLTPTIAVINSLESEHMDTYGTIEELRKAFIAFANKVPFYGRVICCVDWPEIRKLIPHLNRRYTTFGID
EPADVMASDMVMDKNRSRFTVRASGKEYPGVSLNVPGRHNVMNALAAFASGLELGIAPERIIAGLTRYSGMRRRFQIKYD
NSAGVLVVDDYAHHPSEVKAAVKAARDGWPNAEIVAVFQPHLFSRTREFADEYGWALLRADKIYVADIYPSREKAADYPG
VSGSLVAAAVHKAGGKHAEFIADRELLYQTVETCPQKSTVVLFMGAGDITHLSTRLAGEWINKFSA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=465, Percent_Identity=41.9354838709677, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI1790680, Length=470, Percent_Identity=28.5106382978723, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CHLPD (A1BJX7)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_913128.1
- ProteinModelPortal:   A1BJX7
- SMR:   A1BJX7
- STRING:   A1BJX7
- GeneID:   4570694
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2720
- NMPDR:   fig|290317.7.peg.2841
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50598; Mature: 50598

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGKTKSVHIVGIGGAGMSAIAELLLTSGFGVTGSDLSSGEVTERLSERGAVIYQGHKA
CCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCH
EQVGESDVVVYSSAIRPAENVEIVAAEQAGIPVIKRDEMLGELMRYNYGVCVSGTHGKTT
HHCCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCHH
TTAMIATMLIEAGESPTVMIGGVSDYLKGSTVVGSGKYLVIEADEFDRAFLKLTPTIAVI
HHHHHHHHHHHCCCCCEEEEECHHHHHCCCEEEECCCEEEEECCCCCCHHHEECHHHHHH
NSLESEHMDTYGTIEELRKAFIAFANKVPFYGRVICCVDWPEIRKLIPHLNRRYTTFGID
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCC
EPADVMASDMVMDKNRSRFTVRASGKEYPGVSLNVPGRHNVMNALAAFASGLELGIAPER
CCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
IIAGLTRYSGMRRRFQIKYDNSAGVLVVDDYAHHPSEVKAAVKAARDGWPNAEIVAVFQP
HHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
HLFSRTREFADEYGWALLRADKIYVADIYPSREKAADYPGVSGSLVAAAVHKAGGKHAEF
HHHHHHHHHHHHHCEEEEEECEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
IADRELLYQTVETCPQKSTVVLFMGAGDITHLSTRLAGEWINKFSA
HHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELGKTKSVHIVGIGGAGMSAIAELLLTSGFGVTGSDLSSGEVTERLSERGAVIYQGHKA
CCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCH
EQVGESDVVVYSSAIRPAENVEIVAAEQAGIPVIKRDEMLGELMRYNYGVCVSGTHGKTT
HHCCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCHH
TTAMIATMLIEAGESPTVMIGGVSDYLKGSTVVGSGKYLVIEADEFDRAFLKLTPTIAVI
HHHHHHHHHHHCCCCCEEEEECHHHHHCCCEEEECCCEEEEECCCCCCHHHEECHHHHHH
NSLESEHMDTYGTIEELRKAFIAFANKVPFYGRVICCVDWPEIRKLIPHLNRRYTTFGID
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCC
EPADVMASDMVMDKNRSRFTVRASGKEYPGVSLNVPGRHNVMNALAAFASGLELGIAPER
CCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHH
IIAGLTRYSGMRRRFQIKYDNSAGVLVVDDYAHHPSEVKAAVKAARDGWPNAEIVAVFQP
HHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
HLFSRTREFADEYGWALLRADKIYVADIYPSREKAADYPGVSGSLVAAAVHKAGGKHAEF
HHHHHHHHHHHHHCEEEEEECEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
IADRELLYQTVETCPQKSTVVLFMGAGDITHLSTRLAGEWINKFSA
HHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA