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The map label for this gene is glmS [H]

Identifier: 119358373

GI number: 119358373

Start: 2988898

End: 2990802

Strand: Reverse

Name: glmS [H]

Synonym: Cpha266_2605

Alternate gene names: 119358373

Gene position: 2990802-2988898 (Counterclockwise)

Preceding gene: 119358374

Following gene: 119358372

Centisome position: 95.43

GC content: 53.44

Gene sequence:

>1905_bases
ATGTGCGGAATTGTTGGATATATCGGTAAGCGGGATGCGGCTCCGTTGCTTTTGCATGGGTTGAAGCGGCTTGAGTATCG
GGGGTATGATTCTGCTGGTATTGCGGTGATCGGTGAAGAACGTGTTAAGGAGAAAGAGGAAGAGCGTGCAGAGCGTGATG
TGTCTGGCGAGGAAGGGATTCGGGTTGTGAAGCGGAAGGGGAATGTTGCGGCTCTTGCTGAGGCGATTGCTGGTTGCGAT
GGCGGGTTTTTGGGTGCTACGGTGGGTATCGGGCACACCCGGTGGGCGACGCATGGCGATCCGAGCGACAGGAATGCGCA
TCCTCATCTGAATGAAGCGGGTGATATTGCGCTGATTCATAATGGCATTATTGAGAATCATGCGGCTTTGCGCGTAGAGC
TGGAGAAGTATGGGTATTCGTTTGTGAGCGATACGGATTCGGAAGTGCTGGTGCATCTGATTGATCATTTGTGGGCGAAT
ATTCCGTTTCTTGATTTCGAGTCGGCGGTACGGCAGGCTTTGAGCATCGTTGAGGGGGCGTATGGTATCTGCGTTATTTC
GATGCGCGAGCCTGACCGGTTGATTGTTGCCCGTAAAGGGAGCCCGCTGGTGATCGGCGTTGGTGAGGGGGAGTATTTTG
TTGCATCCGATGCTGCTCCGCTTGTTGAGTACACGAGGCATGTGGTCTATCTTGCCGATGGGGATATGGCTGTCGTAAGG
CGCGACGGGTTTAAGGTCAAGTCTATCGGAAATATCGAGCGGGAGAGTATGGTGACGGAGCTTGATTTTGAGATTGAGGA
GATCGAGAAGGGCGGGTTTGAGCATTTTATGCTGAAGGAGATATTTGAGCAGCCATCAGTGATGCGCGATGTGATGCGCG
GCAGGGTGAGTGTTGAGCATAATGCGCTGCATCTTGGGGGTATACAGGATCATCTGGATACGTTGCGGGGTGCGAAGCGA
ATGGTGATTCTTGCGTGCGGAACAAGCTGGCATGCGGGGCTGATCGGGAAGTATCTGATCGAGGAGTTTGCCCGGATTTG
CGTTGAGGTCGATTATGCTTCGGAGTTTCGGTACCGGAACCCGATCGTTGGTCCGGGCGATGTGGTGATCGTGATCTCTC
AGTCGGGGGAGACGGCCGATACGCTTGCCGCTCTGCGTATTGCGAAGGAGAGGGGCGCGACGGTTATGGGGATATGCAAT
GTGGTTGGTTCGACGATTGCTCGCGAAACGCATTTTGGCATGTATACGCATGCGGGGCCTGAAATCGGTGTGGCGTCAAC
CAAGGCGTTTACGGCCCAGGTTGTTGCGCTGTTTATGATTGCGGTACAGTTGAGAATGGGAAATCCGGAGATGAGCGGGG
TTGAAACTTCGGTTCTTCTTCAGGAGTTGCTTGCGGTTCCCGATAAGGCTGAGCAGATTCTTCGGCTGAATGATGACATT
TTGTCTATTGCGGAGAGTTATTGGGATGCCGAGCATGTTCTGTATCTCGGTAGGGGGTATAATTTCCCTGTTGCTTTGGA
GGGGGCGCTGAAGTTGAAGGAGATCTCTTATATCCATGCCGAGGGGTATCCGGCAGCGGAGATGAAGCATGGTCCGATTG
CTTTGATTGATGAGGATGTGCCGGTGGTATTTATTGCTATCCGGGATCATTCGTACAGGAAGGTGCTGAGCAATATTGAG
GAGGTTCGAAGCCGGAAGGGGCGCGTGATTGCTATTGCTACGGAGGGCGATCGGGAAATCGGACGGATTGCCGAGCATGT
GATTTATATCCCCGAAGCCGCTGCTGCGCTGATGCCGTTGTTGACGGTTATTCCGTTGCAGCTTCTGGCTTACCATATCG
CAACGTTGCGCGGCTGCAATGTCGATCGCCCAAGAAATCTCGCCAAGTCAGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
TTATTGGTTCGGCTTTGCTGATCCGGTAATCTGTTGCTTTTTTTATTTGAGTGCAGGATAATTTTTTCCTGTGAATCATA
TATATATAAAATAATAGGTT

Downstream 100 bases:

>100_bases
AGGGGGCCTCGAATGGGGATGAAGAGGAAGAGTTTGCCCACGAATTGACACGAATTTTCACGAAAAGAAATTGGCAGTTG
GTTTTCTCTGGCTTCGCCGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MCGIVGYIGKRDAAPLLLHGLKRLEYRGYDSAGIAVIGEERVKEKEEERAERDVSGEEGIRVVKRKGNVAALAEAIAGCD
GGFLGATVGIGHTRWATHGDPSDRNAHPHLNEAGDIALIHNGIIENHAALRVELEKYGYSFVSDTDSEVLVHLIDHLWAN
IPFLDFESAVRQALSIVEGAYGICVISMREPDRLIVARKGSPLVIGVGEGEYFVASDAAPLVEYTRHVVYLADGDMAVVR
RDGFKVKSIGNIERESMVTELDFEIEEIEKGGFEHFMLKEIFEQPSVMRDVMRGRVSVEHNALHLGGIQDHLDTLRGAKR
MVILACGTSWHAGLIGKYLIEEFARICVEVDYASEFRYRNPIVGPGDVVIVISQSGETADTLAALRIAKERGATVMGICN
VVGSTIARETHFGMYTHAGPEIGVASTKAFTAQVVALFMIAVQLRMGNPEMSGVETSVLLQELLAVPDKAEQILRLNDDI
LSIAESYWDAEHVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDVPVVFIAIRDHSYRKVLSNIE
EVRSRKGRVIAIATEGDREIGRIAEHVIYIPEAAAALMPLLTVIPLQLLAYHIATLRGCNVDRPRNLAKSVTVE

Sequences:

>Translated_634_residues
MCGIVGYIGKRDAAPLLLHGLKRLEYRGYDSAGIAVIGEERVKEKEEERAERDVSGEEGIRVVKRKGNVAALAEAIAGCD
GGFLGATVGIGHTRWATHGDPSDRNAHPHLNEAGDIALIHNGIIENHAALRVELEKYGYSFVSDTDSEVLVHLIDHLWAN
IPFLDFESAVRQALSIVEGAYGICVISMREPDRLIVARKGSPLVIGVGEGEYFVASDAAPLVEYTRHVVYLADGDMAVVR
RDGFKVKSIGNIERESMVTELDFEIEEIEKGGFEHFMLKEIFEQPSVMRDVMRGRVSVEHNALHLGGIQDHLDTLRGAKR
MVILACGTSWHAGLIGKYLIEEFARICVEVDYASEFRYRNPIVGPGDVVIVISQSGETADTLAALRIAKERGATVMGICN
VVGSTIARETHFGMYTHAGPEIGVASTKAFTAQVVALFMIAVQLRMGNPEMSGVETSVLLQELLAVPDKAEQILRLNDDI
LSIAESYWDAEHVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDVPVVFIAIRDHSYRKVLSNIE
EVRSRKGRVIAIATEGDREIGRIAEHVIYIPEAAAALMPLLTVIPLQLLAYHIATLRGCNVDRPRNLAKSVTVE
>Mature_634_residues
MCGIVGYIGKRDAAPLLLHGLKRLEYRGYDSAGIAVIGEERVKEKEEERAERDVSGEEGIRVVKRKGNVAALAEAIAGCD
GGFLGATVGIGHTRWATHGDPSDRNAHPHLNEAGDIALIHNGIIENHAALRVELEKYGYSFVSDTDSEVLVHLIDHLWAN
IPFLDFESAVRQALSIVEGAYGICVISMREPDRLIVARKGSPLVIGVGEGEYFVASDAAPLVEYTRHVVYLADGDMAVVR
RDGFKVKSIGNIERESMVTELDFEIEEIEKGGFEHFMLKEIFEQPSVMRDVMRGRVSVEHNALHLGGIQDHLDTLRGAKR
MVILACGTSWHAGLIGKYLIEEFARICVEVDYASEFRYRNPIVGPGDVVIVISQSGETADTLAALRIAKERGATVMGICN
VVGSTIARETHFGMYTHAGPEIGVASTKAFTAQVVALFMIAVQLRMGNPEMSGVETSVLLQELLAVPDKAEQILRLNDDI
LSIAESYWDAEHVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDVPVVFIAIRDHSYRKVLSNIE
EVRSRKGRVIAIATEGDREIGRIAEHVIYIPEAAAALMPLLTVIPLQLLAYHIATLRGCNVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=697, Percent_Identity=39.167862266858, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI205277386, Length=691, Percent_Identity=39.5079594790159, Blast_Score=488, Evalue=1e-138,
Organism=Escherichia coli, GI1790167, Length=641, Percent_Identity=44.7737909516381, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1788651, Length=241, Percent_Identity=28.2157676348548, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=44.212962962963, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=44.212962962963, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=44.212962962963, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6322745, Length=452, Percent_Identity=42.9203539823009, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=37.037037037037, Blast_Score=274, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6323730, Length=222, Percent_Identity=36.036036036036, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357745, Length=701, Percent_Identity=41.2268188302425, Blast_Score=524, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 69538; Mature: 69538

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGKRDAAPLLLHGLKRLEYRGYDSAGIAVIGEERVKEKEEERAERDVSGEEGI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCC
RVVKRKGNVAALAEAIAGCDGGFLGATVGIGHTRWATHGDPSDRNAHPHLNEAGDIALIH
CEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NGIIENHAALRVELEKYGYSFVSDTDSEVLVHLIDHLWANIPFLDFESAVRQALSIVEGA
CCHHCCCCEEEEEHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
YGICVISMREPDRLIVARKGSPLVIGVGEGEYFVASDAAPLVEYTRHVVYLADGDMAVVR
CEEEEEEECCCCEEEEEECCCEEEEEECCCCEEEECCCCHHHHHCCEEEEEECCCEEEEE
RDGFKVKSIGNIERESMVTELDFEIEEIEKGGFEHFMLKEIFEQPSVMRDVMRGRVSVEH
ECCEEEECCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCEEEEC
NALHLGGIQDHLDTLRGAKRMVILACGTSWHAGLIGKYLIEEFARICVEVDYASEFRYRN
CEEEECCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEECCHHHCCCCC
PIVGPGDVVIVISQSGETADTLAALRIAKERGATVMGICNVVGSTIARETHFGMYTHAGP
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCEEECCCC
EIGVASTKAFTAQVVALFMIAVQLRMGNPEMSGVETSVLLQELLAVPDKAEQILRLNDDI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHH
LSIAESYWDAEHVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDV
HHHHHHHCCCCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCC
PVVFIAIRDHSYRKVLSNIEEVRSRKGRVIAIATEGDREIGRIAEHVIYIPEAAAALMPL
CEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHEEECCHHHHHHHHH
LTVIPLQLLAYHIATLRGCNVDRPRNLAKSVTVE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGKRDAAPLLLHGLKRLEYRGYDSAGIAVIGEERVKEKEEERAERDVSGEEGI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCC
RVVKRKGNVAALAEAIAGCDGGFLGATVGIGHTRWATHGDPSDRNAHPHLNEAGDIALIH
CEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NGIIENHAALRVELEKYGYSFVSDTDSEVLVHLIDHLWANIPFLDFESAVRQALSIVEGA
CCHHCCCCEEEEEHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
YGICVISMREPDRLIVARKGSPLVIGVGEGEYFVASDAAPLVEYTRHVVYLADGDMAVVR
CEEEEEEECCCCEEEEEECCCEEEEEECCCCEEEECCCCHHHHHCCEEEEEECCCEEEEE
RDGFKVKSIGNIERESMVTELDFEIEEIEKGGFEHFMLKEIFEQPSVMRDVMRGRVSVEH
ECCEEEECCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCEEEEC
NALHLGGIQDHLDTLRGAKRMVILACGTSWHAGLIGKYLIEEFARICVEVDYASEFRYRN
CEEEECCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEECCHHHCCCCC
PIVGPGDVVIVISQSGETADTLAALRIAKERGATVMGICNVVGSTIARETHFGMYTHAGP
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCEEECCCC
EIGVASTKAFTAQVVALFMIAVQLRMGNPEMSGVETSVLLQELLAVPDKAEQILRLNDDI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHH
LSIAESYWDAEHVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDV
HHHHHHHCCCCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCC
PVVFIAIRDHSYRKVLSNIEEVRSRKGRVIAIATEGDREIGRIAEHVIYIPEAAAALMPL
CEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHEEECCHHHHHHHHH
LTVIPLQLLAYHIATLRGCNVDRPRNLAKSVTVE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]