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The map label for this gene is ppnK

Identifier: 119358341

GI number: 119358341

Start: 2947923

End: 2948780

Strand: Direct

Name: ppnK

Synonym: Cpha266_2573

Alternate gene names: 119358341

Gene position: 2947923-2948780 (Clockwise)

Preceding gene: 119358340

Following gene: 119358342

Centisome position: 94.07

GC content: 54.08

Gene sequence:

>858_bases
ATGAAATTCGGTATTGTCATCAACACATCCAGAGAACGGGCCATCACCCTTGCCCGCGAACTCATGGCATGGCTCACGGA
ACACGGACAAGACTATGTCTTCGACACGGAATCGGCGCTCAGACTCCAGACCGCCAGGACCGCGCCTATTGAAGAGCTTA
ACAAACAGTGCGACGCCTTTGTCTCACTGGGCGGCGACGGCACGCTGCTCTTCACCTCACACTATTCCGTCACCAAACCG
GTCATCGGCATCAACGTCGGCTACCTCGGCTTTTTAACCGAATTCTCGCCTGACGAAATGGTACCGGCAATAGAAAAAGT
CCTGAGCGGCAACTACTCCATACACAACCGATCCCAGCTCGAAGCCACCTTTCGCACAGACGGCAAAATCGAACAACTCA
GAGCGCTCAACGACGTCGTCATTGAAAAAGGCACCTATCCGCGCATACCGACGTTTGTCATCAAACTCGACGGAGAGCTT
CTCGGCTCCTATCGGGCCGACGGAATCATCATCGCTACATCCACCGGCTCGACAGCCTACTCCATGTCTGCAGGAGGACC
GATCATAGCCCCGAAATCAAGCGTTTTTGTCATAACCCCGATCTGCCCGCACATGCTGACGGTAAGGCCGATCGTCATCA
ACGACGAAAAAATCATCGAAGTCTCCATCGACGCCCCCGACGGCGAGTTCCCCCTCAATGGCGACGGACACCTTCGAAAA
CTGCTTGCCCCGCAGGAGACGGTCACCGTTAAAAAATCACAACAGGTCATCAATCTTGTTGCCAACGAGAACCGCGACTA
CTGCGAAATACTGCGAACAAAACTGCTCTGGGGTCGCGAACACGACTCAACCCAATAA

Upstream 100 bases:

>100_bases
AACTTGCCCATGAGGTAAAAGCGCTCAACATGAAAAAAATCGAACAGCGCTTTACCGATGCCAACCAGCTTTACAAAACC
CTTAAAGAGATAAACAGGGA

Downstream 100 bases:

>100_bases
CAACCAACCTCCTCACCCGGAATTCATATACGCCTCAGCTTCATGAATCACAGCATTACCACGTCATCCCTGAACCAGCT
TCTCGGCATACCGCGCGACA

Product: NAD(+) kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKFGIVINTSRERAITLARELMAWLTEHGQDYVFDTESALRLQTARTAPIEELNKQCDAFVSLGGDGTLLFTSHYSVTKP
VIGINVGYLGFLTEFSPDEMVPAIEKVLSGNYSIHNRSQLEATFRTDGKIEQLRALNDVVIEKGTYPRIPTFVIKLDGEL
LGSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVINDEKIIEVSIDAPDGEFPLNGDGHLRK
LLAPQETVTVKKSQQVINLVANENRDYCEILRTKLLWGREHDSTQ

Sequences:

>Translated_285_residues
MKFGIVINTSRERAITLARELMAWLTEHGQDYVFDTESALRLQTARTAPIEELNKQCDAFVSLGGDGTLLFTSHYSVTKP
VIGINVGYLGFLTEFSPDEMVPAIEKVLSGNYSIHNRSQLEATFRTDGKIEQLRALNDVVIEKGTYPRIPTFVIKLDGEL
LGSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVINDEKIIEVSIDAPDGEFPLNGDGHLRK
LLAPQETVTVKKSQQVINLVANENRDYCEILRTKLLWGREHDSTQ
>Mature_285_residues
MKFGIVINTSRERAITLARELMAWLTEHGQDYVFDTESALRLQTARTAPIEELNKQCDAFVSLGGDGTLLFTSHYSVTKP
VIGINVGYLGFLTEFSPDEMVPAIEKVLSGNYSIHNRSQLEATFRTDGKIEQLRALNDVVIEKGTYPRIPTFVIKLDGEL
LGSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVINDEKIIEVSIDAPDGEFPLNGDGHLRK
LLAPQETVTVKKSQQVINLVANENRDYCEILRTKLLWGREHDSTQ

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=260, Percent_Identity=31.1538461538462, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788968, Length=284, Percent_Identity=32.7464788732394, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325068, Length=220, Percent_Identity=34.0909090909091, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320794, Length=252, Percent_Identity=30.952380952381, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322509, Length=184, Percent_Identity=36.4130434782609, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28573828, Length=252, Percent_Identity=32.5396825396825, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28573830, Length=253, Percent_Identity=32.4110671936759, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI161077047, Length=184, Percent_Identity=36.9565217391304, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28573832, Length=253, Percent_Identity=32.4110671936759, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573826, Length=184, Percent_Identity=36.9565217391304, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363323, Length=224, Percent_Identity=30.8035714285714, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653422, Length=224, Percent_Identity=30.8035714285714, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653424, Length=224, Percent_Identity=30.8035714285714, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129957, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363321, Length=224, Percent_Identity=30.8035714285714, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_CHLPD (A1BJI4)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912985.1
- ProteinModelPortal:   A1BJI4
- SMR:   A1BJI4
- STRING:   A1BJI4
- GeneID:   4569088
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2573
- NMPDR:   fig|290317.7.peg.2692
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   FESFMID
- ProtClustDB:   CLSK637151
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31479; Mature: 31479

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGIVINTSRERAITLARELMAWLTEHGQDYVFDTESALRLQTARTAPIEELNKQCDAF
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHEE
VSLGGDGTLLFTSHYSVTKPVIGINVGYLGFLTEFSPDEMVPAIEKVLSGNYSIHNRSQL
EEECCCCEEEEEECCCCCCCEEEEECCCEEHCCCCCCHHHHHHHHHHHCCCCCCCCCHHE
EATFRTDGKIEQLRALNDVVIEKGTYPRIPTFVIKLDGELLGSYRADGIIIATSTGSTAY
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCCCCCCCEEEEECCCCCEE
SMSAGGPIIAPKSSVFVITPICPHMLTVRPIVINDEKIIEVSIDAPDGEFPLNGDGHLRK
EECCCCCEECCCCCEEEECCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHH
LLAPQETVTVKKSQQVINLVANENRDYCEILRTKLLWGREHDSTQ
HCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKFGIVINTSRERAITLARELMAWLTEHGQDYVFDTESALRLQTARTAPIEELNKQCDAF
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHEE
VSLGGDGTLLFTSHYSVTKPVIGINVGYLGFLTEFSPDEMVPAIEKVLSGNYSIHNRSQL
EEECCCCEEEEEECCCCCCCEEEEECCCEEHCCCCCCHHHHHHHHHHHCCCCCCCCCHHE
EATFRTDGKIEQLRALNDVVIEKGTYPRIPTFVIKLDGELLGSYRADGIIIATSTGSTAY
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCCCCCCCEEEEECCCCCEE
SMSAGGPIIAPKSSVFVITPICPHMLTVRPIVINDEKIIEVSIDAPDGEFPLNGDGHLRK
EECCCCCEECCCCCEEEECCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHH
LLAPQETVTVKKSQQVINLVANENRDYCEILRTKLLWGREHDSTQ
HCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA