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The map label for this gene is pepQ [H]

Identifier: 119358286

GI number: 119358286

Start: 2882755

End: 2883927

Strand: Direct

Name: pepQ [H]

Synonym: Cpha266_2518

Alternate gene names: 119358286

Gene position: 2882755-2883927 (Clockwise)

Preceding gene: 119358285

Following gene: 119358287

Centisome position: 91.99

GC content: 52.09

Gene sequence:

>1173_bases
ATGCTGACTATAACAGAATCGGAACACCGCATATCGCACATGCAGAGGCGACTTCAAGAGAGTGGAATCTCAGGCGCGCT
CTTCATGTTCCCCATTGATATCTACTATTTCAGCGGCACCCGCCAGAACGCTGCGCTCTGGATGCCTGCGGAAGGAGTAC
CCATACTCTTCGTGCGAAAAAGCCTCACCCGAGCAAGAGCGGAAAGCCCTCTCGTCGACATCCGGCCCTTTCCCTCCGGC
AAAGAGTTCCCGACACTGTTCAGCGATGAAATCATAACCATCGGCATGACCTTTGACGTCATTCCGGTACAGCAGTTCAA
CTACTACACAAAAGTTCTTCCAGGCCGGAAATTCGTCGATATCTCACCAATTATCCGTGAGATCCGATCCGTTAAATCGA
ACGCAGAACTCGAAAAGCTTCGCTCGGGAGCAGAAAAGCTCTGCTCTGTATTCAGCGAAGTGCCGCAGTTCCTGAAAGCA
GGGATGCGGGAGCTTGACCTGGCAGCAGAGTTCGAATACCGGCTTCGAAAAGCCGGTCATGAAGGCTATGTCCGCATGAG
AGCCTTCAATCAGGAACTTGCCGGCGGCCTGGCAGTCTCAAAAGGGGGAACTGCTCACGGGTGCTTTGACGGCGCCGTAA
CCGGAAAAGGGCTTTCATGCGCATCACCGCAAGGGGCCTCCCTTGAAATAATCCCTGAAAACGAACCCATTCTGCTTGAT
TACGCAGGAGTTTTCGGCGGTTATATTTCCGACATGACCCGGATTTTCGTAATCGGCTCGCTTGACACCCGTTTGCAGGA
AGCGTTCGATGTTGCCATCAGCATTCAGTCCGCCATACAACAGGCTATGATACCCGGAGCCATTGCCGAAAATCTATACC
TCCTCGCCCTGCAAATGGCTGAAAAGGCCGGATTAGACTCCTGCTTTATGGGGCTGCCTGGAGAACAGTCAAAATTCGTC
GGCCATGGCGTTGGCCTCGAACTTGACGAGTTCCCGATACTTGCAAAAGGTTTCAACATGCCGCTTCAGGCAGGTCAGAC
CATCGCCGTCGAACCCAAGTTCGTCATACCCGGCAAAGGAGTCATCGGCATTGAAAACACCTTTATTGTCAGCGGGCATG
GCGGATTAAAAGTCACCGATATCCCTGATGAAATAGTATTCATAAAACCATGA

Upstream 100 bases:

>100_bases
GAAGAGGGCATCAAAAGCGGCGGCTATGAAGGCAAGCTGAAAGCCAGGGACCTCGCAGAAATCGTTGCTGAACGATTAAA
CAACCCATAACAAACAACTT

Downstream 100 bases:

>100_bases
AGCAGCAATTTTACATAAAAACAGGCATGGCGGCTGCATTATTGATCATGCTGCAAACGTTTTACAAAACCCATGAAACT
ACTCGTCTGTATCAAACAGA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLTITESEHRISHMQRRLQESGISGALFMFPIDIYYFSGTRQNAALWMPAEGVPILFVRKSLTRARAESPLVDIRPFPSG
KEFPTLFSDEIITIGMTFDVIPVQQFNYYTKVLPGRKFVDISPIIREIRSVKSNAELEKLRSGAEKLCSVFSEVPQFLKA
GMRELDLAAEFEYRLRKAGHEGYVRMRAFNQELAGGLAVSKGGTAHGCFDGAVTGKGLSCASPQGASLEIIPENEPILLD
YAGVFGGYISDMTRIFVIGSLDTRLQEAFDVAISIQSAIQQAMIPGAIAENLYLLALQMAEKAGLDSCFMGLPGEQSKFV
GHGVGLELDEFPILAKGFNMPLQAGQTIAVEPKFVIPGKGVIGIENTFIVSGHGGLKVTDIPDEIVFIKP

Sequences:

>Translated_390_residues
MLTITESEHRISHMQRRLQESGISGALFMFPIDIYYFSGTRQNAALWMPAEGVPILFVRKSLTRARAESPLVDIRPFPSG
KEFPTLFSDEIITIGMTFDVIPVQQFNYYTKVLPGRKFVDISPIIREIRSVKSNAELEKLRSGAEKLCSVFSEVPQFLKA
GMRELDLAAEFEYRLRKAGHEGYVRMRAFNQELAGGLAVSKGGTAHGCFDGAVTGKGLSCASPQGASLEIIPENEPILLD
YAGVFGGYISDMTRIFVIGSLDTRLQEAFDVAISIQSAIQQAMIPGAIAENLYLLALQMAEKAGLDSCFMGLPGEQSKFV
GHGVGLELDEFPILAKGFNMPLQAGQTIAVEPKFVIPGKGVIGIENTFIVSGHGGLKVTDIPDEIVFIKP
>Mature_390_residues
MLTITESEHRISHMQRRLQESGISGALFMFPIDIYYFSGTRQNAALWMPAEGVPILFVRKSLTRARAESPLVDIRPFPSG
KEFPTLFSDEIITIGMTFDVIPVQQFNYYTKVLPGRKFVDISPIIREIRSVKSNAELEKLRSGAEKLCSVFSEVPQFLKA
GMRELDLAAEFEYRLRKAGHEGYVRMRAFNQELAGGLAVSKGGTAHGCFDGAVTGKGLSCASPQGASLEIIPENEPILLD
YAGVFGGYISDMTRIFVIGSLDTRLQEAFDVAISIQSAIQQAMIPGAIAENLYLLALQMAEKAGLDSCFMGLPGEQSKFV
GHGVGLELDEFPILAKGFNMPLQAGQTIAVEPKFVIPGKGVIGIENTFIVSGHGGLKVTDIPDEIVFIKP

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=288, Percent_Identity=25.3472222222222, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788728, Length=277, Percent_Identity=25.6317689530686, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 42588; Mature: 42588

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTITESEHRISHMQRRLQESGISGALFMFPIDIYYFSGTRQNAALWMPAEGVPILFVRK
CEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCEEEECCCCCEEEEEHH
SLTRARAESPLVDIRPFPSGKEFPTLFSDEIITIGMTFDVIPVQQFNYYTKVLPGRKFVD
HHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEHHHHCHHHHCCCCCCEEE
ISPIIREIRSVKSNAELEKLRSGAEKLCSVFSEVPQFLKAGMRELDLAAEFEYRLRKAGH
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGYVRMRAFNQELAGGLAVSKGGTAHGCFDGAVTGKGLSCASPQGASLEIIPENEPILLD
CCEEEEEEHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
YAGVFGGYISDMTRIFVIGSLDTRLQEAFDVAISIQSAIQQAMIPGAIAENLYLLALQMA
EHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EKAGLDSCFMGLPGEQSKFVGHGVGLELDEFPILAKGFNMPLQAGQTIAVEPKFVIPGKG
HHCCCCHHHCCCCCCCCCCEECCCCCCCCCCCEEECCCCCCCCCCCEEEECCEEEECCCC
VIGIENTFIVSGHGGLKVTDIPDEIVFIKP
EEEECCEEEEECCCCEEEEECCCCEEEECC
>Mature Secondary Structure
MLTITESEHRISHMQRRLQESGISGALFMFPIDIYYFSGTRQNAALWMPAEGVPILFVRK
CEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCEEEECCCCCEEEEEHH
SLTRARAESPLVDIRPFPSGKEFPTLFSDEIITIGMTFDVIPVQQFNYYTKVLPGRKFVD
HHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEHHHHCHHHHCCCCCCEEE
ISPIIREIRSVKSNAELEKLRSGAEKLCSVFSEVPQFLKAGMRELDLAAEFEYRLRKAGH
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGYVRMRAFNQELAGGLAVSKGGTAHGCFDGAVTGKGLSCASPQGASLEIIPENEPILLD
CCEEEEEEHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
YAGVFGGYISDMTRIFVIGSLDTRLQEAFDVAISIQSAIQQAMIPGAIAENLYLLALQMA
EHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EKAGLDSCFMGLPGEQSKFVGHGVGLELDEFPILAKGFNMPLQAGQTIAVEPKFVIPGKG
HHCCCCHHHCCCCCCCCCCEECCCCCCCCCCCEEECCCCCCCCCCCEEEECCEEEECCCC
VIGIENTFIVSGHGGLKVTDIPDEIVFIKP
EEEECCEEEEECCCCEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]