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The map label for this gene is moaC [H]

Identifier: 119358237

GI number: 119358237

Start: 2842033

End: 2842971

Strand: Reverse

Name: moaC [H]

Synonym: Cpha266_2469

Alternate gene names: 119358237

Gene position: 2842971-2842033 (Counterclockwise)

Preceding gene: 119358238

Following gene: 119358236

Centisome position: 90.72

GC content: 49.84

Gene sequence:

>939_bases
ATGTTTACCCATCTTGACAGCAGCGGGAACGTTGCCATGGTTGATGTTTCCGGAAAGCCCGGTACGATGAGAAGCGCTAG
GGCTTCAGGTCATATTGCCATGAGTCCCGCAACCATAGGTTTGCTTGAAGAGAACGCATTGCCGAAGGGCAATGTGCTTA
CGGCGGCAAAACTGGCTGGAATTCAGGCAGCAAAACAAGCCTCGGCACTGATTCCTTTGTGTCATCAGCTCAATCTTTCA
TGGATTGATCTTTCTTTTGACGTTCAGTCCGATCGAATTCTTATTACGGCGACGGTAAAAACAAAGGAAGCGACGGGTGT
GGAGATGGAGGCTCTTACAGCGGTTTCTGTAGCCGCGCTTACTATTTACGATATGTGCAAGGCTGTCGATCTTTCCATGG
AGATTGGCTCGATTCGCCTTGATGAGAAAAGAGGCGGAAAACGCCAGGAAACTCAGCGATACAGGCCGAAAACTTCAATT
CTTGTGCTATCTGATTCAATTTCTTCAGGTCACGCTGACGACCGTTCAGGAAAACTTCTCAAGGAGGGGTTTGCCGCGGC
AGGATGCCCGATTTCTGAATTCCGGATTATTGCCGATAACAGGGAAGAGATTGCTGCAATTATTGATGAGTGGACGGCAG
GCGGGGTTGAATTGATCGTCACATCCGGTGGAACAGGCCTGGGGCCTCGAGATGTTACCGTTGATACGCTGCAGCCGAAA
TTTACCAGACGGCTTCCAGGAATAGAACAGGCGTTATTTACCTGGGGGCAAAGCAAAACTCGAACCGCAATGCTGTCGAG
ACTTGTTGCCGGTATGATTGATTCCACTCTGGTCATCTGTCTTCCCGGAAGTACCGGTGCTGCCGGTGATGCTCTTGAAG
TGCTGGTTCCAGCCGTTTTTCACGTTTTTTCCATGATAAAGGGAGAGGGTCACGTATGA

Upstream 100 bases:

>100_bases
TGCAATTGCTGATGGCAATCATTACCCTTTGCTTTACTGCTGCCGGAACATTTTCGTCTGCTGACAGCGGGGTGATAATA
TAAAAAGAACAGGAGTTTCG

Downstream 100 bases:

>100_bases
TGATTACTGTTCAGGAGGCATTTCGAATCGTTACGGAATCTGTTTTGCCGATTGTTGCCGAAAAGCTCTCATTGCCGTAC
CTGCAGGGTCGGATGCTTGC

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MFTHLDSSGNVAMVDVSGKPGTMRSARASGHIAMSPATIGLLEENALPKGNVLTAAKLAGIQAAKQASALIPLCHQLNLS
WIDLSFDVQSDRILITATVKTKEATGVEMEALTAVSVAALTIYDMCKAVDLSMEIGSIRLDEKRGGKRQETQRYRPKTSI
LVLSDSISSGHADDRSGKLLKEGFAAAGCPISEFRIIADNREEIAAIIDEWTAGGVELIVTSGGTGLGPRDVTVDTLQPK
FTRRLPGIEQALFTWGQSKTRTAMLSRLVAGMIDSTLVICLPGSTGAAGDALEVLVPAVFHVFSMIKGEGHV

Sequences:

>Translated_312_residues
MFTHLDSSGNVAMVDVSGKPGTMRSARASGHIAMSPATIGLLEENALPKGNVLTAAKLAGIQAAKQASALIPLCHQLNLS
WIDLSFDVQSDRILITATVKTKEATGVEMEALTAVSVAALTIYDMCKAVDLSMEIGSIRLDEKRGGKRQETQRYRPKTSI
LVLSDSISSGHADDRSGKLLKEGFAAAGCPISEFRIIADNREEIAAIIDEWTAGGVELIVTSGGTGLGPRDVTVDTLQPK
FTRRLPGIEQALFTWGQSKTRTAMLSRLVAGMIDSTLVICLPGSTGAAGDALEVLVPAVFHVFSMIKGEGHV
>Mature_312_residues
MFTHLDSSGNVAMVDVSGKPGTMRSARASGHIAMSPATIGLLEENALPKGNVLTAAKLAGIQAAKQASALIPLCHQLNLS
WIDLSFDVQSDRILITATVKTKEATGVEMEALTAVSVAALTIYDMCKAVDLSMEIGSIRLDEKRGGKRQETQRYRPKTSI
LVLSDSISSGHADDRSGKLLKEGFAAAGCPISEFRIIADNREEIAAIIDEWTAGGVELIVTSGGTGLGPRDVTVDTLQPK
FTRRLPGIEQALFTWGQSKTRTAMLSRLVAGMIDSTLVICLPGSTGAAGDALEVLVPAVFHVFSMIKGEGHV

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI66932975, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1787001, Length=148, Percent_Identity=47.972972972973, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787000, Length=155, Percent_Identity=32.258064516129, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=44.2953020134228, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17564954, Length=157, Percent_Identity=30.5732484076433, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574490, Length=162, Percent_Identity=46.2962962962963, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574492, Length=153, Percent_Identity=48.3660130718954, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33016; Mature: 33016

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTHLDSSGNVAMVDVSGKPGTMRSARASGHIAMSPATIGLLEENALPKGNVLTAAKLAG
CCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCEEHHHHHHH
IQAAKQASALIPLCHQLNLSWIDLSFDVQSDRILITATVKTKEATGVEMEALTAVSVAAL
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
TIYDMCKAVDLSMEIGSIRLDEKRGGKRQETQRYRPKTSILVLSDSISSGHADDRSGKLL
HHHHHHHHHCCEEEECCEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHH
KEGFAAAGCPISEFRIIADNREEIAAIIDEWTAGGVELIVTSGGTGLGPRDVTVDTLQPK
HHCCCCCCCCHHHEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCH
FTRRLPGIEQALFTWGQSKTRTAMLSRLVAGMIDSTLVICLPGSTGAAGDALEVLVPAVF
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
HVFSMIKGEGHV
HHHHHHCCCCCC
>Mature Secondary Structure
MFTHLDSSGNVAMVDVSGKPGTMRSARASGHIAMSPATIGLLEENALPKGNVLTAAKLAG
CCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCEEHHHHHHH
IQAAKQASALIPLCHQLNLSWIDLSFDVQSDRILITATVKTKEATGVEMEALTAVSVAAL
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
TIYDMCKAVDLSMEIGSIRLDEKRGGKRQETQRYRPKTSILVLSDSISSGHADDRSGKLL
HHHHHHHHHCCEEEECCEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHH
KEGFAAAGCPISEFRIIADNREEIAAIIDEWTAGGVELIVTSGGTGLGPRDVTVDTLQPK
HHCCCCCCCCHHHEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCH
FTRRLPGIEQALFTWGQSKTRTAMLSRLVAGMIDSTLVICLPGSTGAAGDALEVLVPAVF
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
HVFSMIKGEGHV
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]