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The map label for this gene is moeA [H]

Identifier: 119358236

GI number: 119358236

Start: 2840789

End: 2842036

Strand: Reverse

Name: moeA [H]

Synonym: Cpha266_2468

Alternate gene names: 119358236

Gene position: 2842036-2840789 (Counterclockwise)

Preceding gene: 119358237

Following gene: 119358224

Centisome position: 90.69

GC content: 51.6

Gene sequence:

>1248_bases
ATGATGATTACTGTTCAGGAGGCATTTCGAATCGTTACGGAATCTGTTTTGCCGATTGTTGCCGAAAAGCTCTCATTGCC
GTACCTGCAGGGTCGGATGCTTGCTGAAGATGTTGCCGCTCCGTTTCCACTTCCCAGATTCACCAACGCCGCTATGGATG
GATTTGCCCTGCGTATGGATGATATTTCCGGACTTTCGGACGGCTCTCCTTCGAGGCTGACGATTACGCAGGAAATTGCG
GCGGGCGCTCTCTCTTCTTTTCCCGTCTTTTCCGGTTGCTGCGCGCAGATCATGACCGGAGCTCCTATGCCAGAAGGTGC
GGATACGGTTGTTCCCTTTGAAGATACCAGCGGTTTCGACGGGGAGTCTGTTCTGGTTTACAAAGCGCCAAAACCAAAAG
CAAATGTGCGCTACAGGGGTGAAGAGGTTTGTGAAGGGGAGCTTCTTCTTCGCAAGGGAACACTCGTAACGCCTGCGGAA
ATTGCTGTTCTGGCCTCATTTGGCTTTGCTTCCGCACTTGTGTCCGGTTTGCCGAAGGTCGCCATATTAACCGTTGGCGA
TGAATTGCGCATGCCTGGCGACCATGCTGAAAATGCCGCAATTTATAACTGTAATCAGTTTATGCTGGAGGCTGCATGTC
GGGCTTCAGGTGTCGGGATTACGGTGATCGGGCATGCCCCGGATGAGCGGAATGCGATGCGTGAAGCGCTTCGTGATGCG
ATGGCAGGCTGTGATCTTCTTCTCACTGCCGGAGGTATTTCTACCGGCAGGTACGATTTTATGCAGGAGCTGCTTGAGGA
ACATGGCGTTGAACGAAAGTTCTGGACGGTGGCGCAAAAGCCTGGAAAACCTCTCTATTTTGGTATCACGCCCGATAAAC
GGCCGGTTTTTGCTCTTCCGGGCAATCCGGTATCGGCGATGGCTTGTTTTATCAAATACGTTGTTCCTGCCCTATCTCGT
CTTCAGGGCAAAGAGCTGTCCGGAAGTATTCGAGCTGAACTTGTCAAATCGTTTGTTCCTGACAGAAAACGGCATCGTTT
TCTCTTTGGAAAAGTGTGGCAGGAGAACGACAGACTCTTGTGTTGCGCAGCATCAAAGGTTGAGTCACACATGATTACTG
CTCTCTGTGGAGCAAACTGCCTGCTTGAGTCGGATCCTTCGGGTGACAGTATTCCTGTTGGCACAACACTCAATTGTACA
ATGCTGCCGTGGGCAACGTTTTCCTCTCTGGAACGTGCGGGGTTGTGA

Upstream 100 bases:

>100_bases
TCTGTCTTCCCGGAAGTACCGGTGCTGCCGGTGATGCTCTTGAAGTGCTGGTTCCAGCCGTTTTTCACGTTTTTTCCATG
ATAAAGGGAGAGGGTCACGT

Downstream 100 bases:

>100_bases
TGAGCCTTGATATGATAAATGGCTTAGCGCTTTGGTACGTTTTGTGCCGGTTTCTGCAACTGGTGAAGTAGATCTGCCGT
TTTCTTCTGAAGAGAGACAT

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MMITVQEAFRIVTESVLPIVAEKLSLPYLQGRMLAEDVAAPFPLPRFTNAAMDGFALRMDDISGLSDGSPSRLTITQEIA
AGALSSFPVFSGCCAQIMTGAPMPEGADTVVPFEDTSGFDGESVLVYKAPKPKANVRYRGEEVCEGELLLRKGTLVTPAE
IAVLASFGFASALVSGLPKVAILTVGDELRMPGDHAENAAIYNCNQFMLEAACRASGVGITVIGHAPDERNAMREALRDA
MAGCDLLLTAGGISTGRYDFMQELLEEHGVERKFWTVAQKPGKPLYFGITPDKRPVFALPGNPVSAMACFIKYVVPALSR
LQGKELSGSIRAELVKSFVPDRKRHRFLFGKVWQENDRLLCCAASKVESHMITALCGANCLLESDPSGDSIPVGTTLNCT
MLPWATFSSLERAGL

Sequences:

>Translated_415_residues
MMITVQEAFRIVTESVLPIVAEKLSLPYLQGRMLAEDVAAPFPLPRFTNAAMDGFALRMDDISGLSDGSPSRLTITQEIA
AGALSSFPVFSGCCAQIMTGAPMPEGADTVVPFEDTSGFDGESVLVYKAPKPKANVRYRGEEVCEGELLLRKGTLVTPAE
IAVLASFGFASALVSGLPKVAILTVGDELRMPGDHAENAAIYNCNQFMLEAACRASGVGITVIGHAPDERNAMREALRDA
MAGCDLLLTAGGISTGRYDFMQELLEEHGVERKFWTVAQKPGKPLYFGITPDKRPVFALPGNPVSAMACFIKYVVPALSR
LQGKELSGSIRAELVKSFVPDRKRHRFLFGKVWQENDRLLCCAASKVESHMITALCGANCLLESDPSGDSIPVGTTLNCT
MLPWATFSSLERAGL
>Mature_415_residues
MMITVQEAFRIVTESVLPIVAEKLSLPYLQGRMLAEDVAAPFPLPRFTNAAMDGFALRMDDISGLSDGSPSRLTITQEIA
AGALSSFPVFSGCCAQIMTGAPMPEGADTVVPFEDTSGFDGESVLVYKAPKPKANVRYRGEEVCEGELLLRKGTLVTPAE
IAVLASFGFASALVSGLPKVAILTVGDELRMPGDHAENAAIYNCNQFMLEAACRASGVGITVIGHAPDERNAMREALRDA
MAGCDLLLTAGGISTGRYDFMQELLEEHGVERKFWTVAQKPGKPLYFGITPDKRPVFALPGNPVSAMACFIKYVVPALSR
LQGKELSGSIRAELVKSFVPDRKRHRFLFGKVWQENDRLLCCAASKVESHMITALCGANCLLESDPSGDSIPVGTTLNCT
MLPWATFSSLERAGL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=336, Percent_Identity=32.7380952380952, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI10880983, Length=336, Percent_Identity=32.7380952380952, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1787049, Length=392, Percent_Identity=33.9285714285714, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=409, Percent_Identity=26.161369193154, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562606, Length=327, Percent_Identity=25.3822629969419, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=396, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24638841, Length=396, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44620; Mature: 44620

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITVQEAFRIVTESVLPIVAEKLSLPYLQGRMLAEDVAAPFPLPRFTNAAMDGFALRMD
CEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEC
DISGLSDGSPSRLTITQEIAAGALSSFPVFSGCCAQIMTGAPMPEGADTVVPFEDTSGFD
CCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
GESVLVYKAPKPKANVRYRGEEVCEGELLLRKGTLVTPAEIAVLASFGFASALVSGLPKV
CCEEEEEECCCCCCCEEECCCHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCE
AILTVGDELRMPGDHAENAAIYNCNQFMLEAACRASGVGITVIGHAPDERNAMREALRDA
EEEEECHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
MAGCDLLLTAGGISTGRYDFMQELLEEHGVERKFWTVAQKPGKPLYFGITPDKRPVFALP
HCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHHHCCCCCCEEEEECCCCCEEEEEC
GNPVSAMACFIKYVVPALSRLQGKELSGSIRAELVKSFVPDRKRHRFLFGKVWQENDRLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEE
CCAASKVESHMITALCGANCLLESDPSGDSIPVGTTLNCTMLPWATFSSLERAGL
EEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCC
>Mature Secondary Structure
MMITVQEAFRIVTESVLPIVAEKLSLPYLQGRMLAEDVAAPFPLPRFTNAAMDGFALRMD
CEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEC
DISGLSDGSPSRLTITQEIAAGALSSFPVFSGCCAQIMTGAPMPEGADTVVPFEDTSGFD
CCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
GESVLVYKAPKPKANVRYRGEEVCEGELLLRKGTLVTPAEIAVLASFGFASALVSGLPKV
CCEEEEEECCCCCCCEEECCCHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCE
AILTVGDELRMPGDHAENAAIYNCNQFMLEAACRASGVGITVIGHAPDERNAMREALRDA
EEEEECHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
MAGCDLLLTAGGISTGRYDFMQELLEEHGVERKFWTVAQKPGKPLYFGITPDKRPVFALP
HCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHHHCCCCCCEEEEECCCCCEEEEEC
GNPVSAMACFIKYVVPALSRLQGKELSGSIRAELVKSFVPDRKRHRFLFGKVWQENDRLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEE
CCAASKVESHMITALCGANCLLESDPSGDSIPVGTTLNCTMLPWATFSSLERAGL
EEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]