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The map label for this gene is map [H]

Identifier: 119358170

GI number: 119358170

Start: 2786930

End: 2787727

Strand: Reverse

Name: map [H]

Synonym: Cpha266_2402

Alternate gene names: 119358170

Gene position: 2787727-2786930 (Counterclockwise)

Preceding gene: 119358171

Following gene: 119358169

Centisome position: 88.95

GC content: 48.37

Gene sequence:

>798_bases
ATGATTACCATAAAAAGCGAACGGGAAATTGACTTGATGAGAGAGTCGGGAATGCTCGTTGCCCTGACTCTTGACATGCT
TGAACAGGAGATACGTTCAGGAATGTCAACCAGACAGCTTGATGAGATGGCTGAGCAGTTTATCAGAGATCATCATGCCG
TACCAAGTTTTTTGAACTATGCCCCAAAAGGGGATCCCGATGTGACTCCATATCCGGCTACGCTTTGCGTATCGATCAAT
GAAGAGGTTGTTCATGGGGTCCCGAGCCCAAAAAAGATTATCAGGGAGGGCGATATTGTTTCTGTTGATTGCGGAGTTTA
TAAAAGCGGCTATCACGGCGATGCCGCCAGAACTTTTATCATAGGAACTATTGATCCTGCCGTACGCAAGCTTGTGGAAG
TAACAAAGGAGTCTCTTGAAAAAGGCATAGCAATGGCCGTAGAAGGTAATCGCCTTCATGATATTTCTTCAGCGATTGAA
GAGCACGCTCGCTCCTATGGATTCAGCGTGATAGAGAATATGGTAGGCCACGGCATCGGGAGCGAGCTCCATGAAGACCC
CGCTGTTCCTAACTACGGGAGAAAAAATACAGGGGTACGGCTGGTTAAAGGAATGGCTCTTGCCATTGAACCGATGATCG
CTCTTGGCCGTTCCAGAAAGGCTGTAAGCCGCAGGGGCGGATGGGTAGCCGTTACAGAAGACGGAAAGCCCTCTGCACAT
TTTGAACACACGATTATTGTCAGACCGGAAAAGGCAGAGGTTCTAACCTGCTCTCGTCTGTCAGGGCATATTTGCTGA

Upstream 100 bases:

>100_bases
CCTGCAGCAGGTTGAAAGTCACCTTCTGATGCGACACTACGACGGCTTTATGAAGACTGGAAAAACACGCGGCCGTCAAC
GGCCTTAAGGAACTGCTGCA

Downstream 100 bases:

>100_bases
AGAACACTACACCTTATAGAAACAAGGGGACTGACCATTGGCCAAAGAAGAAGCAATAGAAATTGAAGGTGTTATACTTG
ATGCCCTTCCTAATGCACAG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MITIKSEREIDLMRESGMLVALTLDMLEQEIRSGMSTRQLDEMAEQFIRDHHAVPSFLNYAPKGDPDVTPYPATLCVSIN
EEVVHGVPSPKKIIREGDIVSVDCGVYKSGYHGDAARTFIIGTIDPAVRKLVEVTKESLEKGIAMAVEGNRLHDISSAIE
EHARSYGFSVIENMVGHGIGSELHEDPAVPNYGRKNTGVRLVKGMALAIEPMIALGRSRKAVSRRGGWVAVTEDGKPSAH
FEHTIIVRPEKAEVLTCSRLSGHIC

Sequences:

>Translated_265_residues
MITIKSEREIDLMRESGMLVALTLDMLEQEIRSGMSTRQLDEMAEQFIRDHHAVPSFLNYAPKGDPDVTPYPATLCVSIN
EEVVHGVPSPKKIIREGDIVSVDCGVYKSGYHGDAARTFIIGTIDPAVRKLVEVTKESLEKGIAMAVEGNRLHDISSAIE
EHARSYGFSVIENMVGHGIGSELHEDPAVPNYGRKNTGVRLVKGMALAIEPMIALGRSRKAVSRRGGWVAVTEDGKPSAH
FEHTIIVRPEKAEVLTCSRLSGHIC
>Mature_265_residues
MITIKSEREIDLMRESGMLVALTLDMLEQEIRSGMSTRQLDEMAEQFIRDHHAVPSFLNYAPKGDPDVTPYPATLCVSIN
EEVVHGVPSPKKIIREGDIVSVDCGVYKSGYHGDAARTFIIGTIDPAVRKLVEVTKESLEKGIAMAVEGNRLHDISSAIE
EHARSYGFSVIENMVGHGIGSELHEDPAVPNYGRKNTGVRLVKGMALAIEPMIALGRSRKAVSRRGGWVAVTEDGKPSAH
FEHTIIVRPEKAEVLTCSRLSGHIC

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=257, Percent_Identity=37.7431906614786, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI40385867, Length=255, Percent_Identity=31.7647058823529, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=37.8378378378378, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71996291, Length=261, Percent_Identity=34.8659003831418, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323273, Length=256, Percent_Identity=35.15625, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21355531, Length=258, Percent_Identity=34.4961240310078, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=35.9683794466403, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29038; Mature: 29038

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKSEREIDLMRESGMLVALTLDMLEQEIRSGMSTRQLDEMAEQFIRDHHAVPSFLNY
CEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHC
APKGDPDVTPYPATLCVSINEEVVHGVPSPKKIIREGDIVSVDCGVYKSGYHGDAARTFI
CCCCCCCCCCCCCEEEEECCHHHHCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCEEEEE
IGTIDPAVRKLVEVTKESLEKGIAMAVEGNRLHDISSAIEEHARSYGFSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEDPAVPNYGRKNTGVRLVKGMALAIEPMIALGRSRKAVSRRGGWVAVTEDGKPSAH
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCCCC
FEHTIIVRPEKAEVLTCSRLSGHIC
CCEEEEECCCCCCEEEEHHHCCCCC
>Mature Secondary Structure
MITIKSEREIDLMRESGMLVALTLDMLEQEIRSGMSTRQLDEMAEQFIRDHHAVPSFLNY
CEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHC
APKGDPDVTPYPATLCVSINEEVVHGVPSPKKIIREGDIVSVDCGVYKSGYHGDAARTFI
CCCCCCCCCCCCCEEEEECCHHHHCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCEEEEE
IGTIDPAVRKLVEVTKESLEKGIAMAVEGNRLHDISSAIEEHARSYGFSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEDPAVPNYGRKNTGVRLVKGMALAIEPMIALGRSRKAVSRRGGWVAVTEDGKPSAH
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCCCC
FEHTIIVRPEKAEVLTCSRLSGHIC
CCEEEEECCCCCCEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]