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The map label for this gene is nadC [H]

Identifier: 119358065

GI number: 119358065

Start: 2625277

End: 2626152

Strand: Reverse

Name: nadC [H]

Synonym: Cpha266_2293

Alternate gene names: 119358065

Gene position: 2626152-2625277 (Counterclockwise)

Preceding gene: 119358069

Following gene: 119358062

Centisome position: 83.8

GC content: 47.95

Gene sequence:

>876_bases
ATGAATAAGGCTCAACAGGATTTTTATGAGGGGTGCCGATCGCGGGCAGTGATGCTTGCTCTTGAGGAGGATCGTTATAT
CGGCGATATTACAACTCTTTCGACTATAGACGACAACAGGGTTGGACGTGCAGAGGTGCGGGCAAAGGAGGATGGCATTC
TTGCTGGCGCAGAGGTTGCACGACAGGTTTTCGCAGCCTGCGATGGTGCGGTTTCGGTTGTTTGTCACCATTCTGACGGC
GATCAACTTATGGTTGGCGATCTTGTGCTTGAAGTTTCAGGAAAACTTGCACCGCTGCTTGTCGGTGAACGAACGGCGCT
TAATTTTATGCAGCGGATGTCGGGCATTGCAACCAAAACAAAACTTTTTGTCGAAAAGGTAAGTCATACGAAGGCCTCTA
TTCTCGATACCAGAAAGACTGCTCCCGGTTTGCGATATTTTGATAAGGAAGCGGTCAGGATCGGAGGAGGACGGAATCAT
CGTTTTGGACTGTTTGATATGATGCTTATCAAAGATAATCATATTGACGCATCCGGAGGGGTTGCCAATGCTCTGCGCAA
GGCCAGGCAATATCGAAAGAAACATGGGCTTGCCGTCAAAATCGAAACGGAAGTCCGTTCGATTGATGAACTTCGCGAGG
CTCTGTCCTGCAAGCCCGATATTGTGCTTCTTGATAACTTTGGTATTGATCTGCTCTCTGATGCGGTAGCTTTTTCGAAA
GAAAATTATCCCATGGTGATACTTGAGGCTTCAGGAAATGTCGGACTGCACAATGTGGCGCAGATTGCGGAAACAGGAGT
TGATTATATATCCATCGGCGAACTGACACACAGTGTCAAGGCGCTTGATCTCTCGATGACCATCAGCCTTGATTGA

Upstream 100 bases:

>100_bases
GGGCGAGAGGCTTTCCGGTTCAATTAAGGAAAAAATAGTACTTTGTGAAAAAGCCGGTTACATCTTTTTGATAAACTAAT
TATTGCACTGGATTGCTGTT

Downstream 100 bases:

>100_bases
ATTGATGGATGGAGATCGGAGCCGATTACCGATGATCATGAGAGGATATAAAAAAACACCGCAGGATTTCTTTGCTCTCC
TGCGGTGTTTTTTTGTTCTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNKAQQDFYEGCRSRAVMLALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVARQVFAACDGAVSVVCHHSDG
DQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKTKLFVEKVSHTKASILDTRKTAPGLRYFDKEAVRIGGGRNH
RFGLFDMMLIKDNHIDASGGVANALRKARQYRKKHGLAVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSK
ENYPMVILEASGNVGLHNVAQIAETGVDYISIGELTHSVKALDLSMTISLD

Sequences:

>Translated_291_residues
MNKAQQDFYEGCRSRAVMLALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVARQVFAACDGAVSVVCHHSDG
DQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKTKLFVEKVSHTKASILDTRKTAPGLRYFDKEAVRIGGGRNH
RFGLFDMMLIKDNHIDASGGVANALRKARQYRKKHGLAVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSK
ENYPMVILEASGNVGLHNVAQIAETGVDYISIGELTHSVKALDLSMTISLD
>Mature_291_residues
MNKAQQDFYEGCRSRAVMLALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVARQVFAACDGAVSVVCHHSDG
DQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKTKLFVEKVSHTKASILDTRKTAPGLRYFDKEAVRIGGGRNH
RFGLFDMMLIKDNHIDASGGVANALRKARQYRKKHGLAVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSK
ENYPMVILEASGNVGLHNVAQIAETGVDYISIGELTHSVKALDLSMTISLD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=248, Percent_Identity=37.0967741935484, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1786299, Length=256, Percent_Identity=41.796875, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=256, Percent_Identity=32.8125, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31779; Mature: 31779

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAQQDFYEGCRSRAVMLALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVA
CCCHHHHHHHHHHCCEEEEEEECCCEEECEEEEEECCCCCCCHHHEEECCCCCEEHHHHH
RQVFAACDGAVSVVCHHSDGDQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKT
HHHHHHCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHHHHHCHHHHH
KLFVEKVSHTKASILDTRKTAPGLRYFDKEAVRIGGGRNHRFGLFDMMLIKDNHIDASGG
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEECCCCCCCCCCEEEEEEECCCCCCCCC
VANALRKARQYRKKHGLAVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSK
HHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCC
ENYPMVILEASGNVGLHNVAQIAETGVDYISIGELTHSVKALDLSMTISLD
CCCCEEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEEEEEC
>Mature Secondary Structure
MNKAQQDFYEGCRSRAVMLALEEDRYIGDITTLSTIDDNRVGRAEVRAKEDGILAGAEVA
CCCHHHHHHHHHHCCEEEEEEECCCEEECEEEEEECCCCCCCHHHEEECCCCCEEHHHHH
RQVFAACDGAVSVVCHHSDGDQLMVGDLVLEVSGKLAPLLVGERTALNFMQRMSGIATKT
HHHHHHCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHHHHHCHHHHH
KLFVEKVSHTKASILDTRKTAPGLRYFDKEAVRIGGGRNHRFGLFDMMLIKDNHIDASGG
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEECCCCCCCCCCEEEEEEECCCCCCCCC
VANALRKARQYRKKHGLAVKIETEVRSIDELREALSCKPDIVLLDNFGIDLLSDAVAFSK
HHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCC
ENYPMVILEASGNVGLHNVAQIAETGVDYISIGELTHSVKALDLSMTISLD
CCCCEEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]