Click here to switch to the map view.

The map label for this gene is aroA

Identifier: 119358049

GI number: 119358049

Start: 2610038

End: 2611342

Strand: Reverse

Name: aroA

Synonym: Cpha266_2277

Alternate gene names: 119358049

Gene position: 2611342-2610038 (Counterclockwise)

Preceding gene: 119358050

Following gene: 119358043

Centisome position: 83.33

GC content: 51.42

Gene sequence:

>1305_bases
ATGAGCGTATTCAAGGGTGAAGTAACCGCGTTGCCGCCTGACAAGTCGATCTCTCATCGTGCGGCACTGATCGGAGCGTT
GTCGGATGGAACGACGGAAATTGTAAATTTTTCCGGAGGGTTCGATAACCAGTCGACACTCGCTGTCCTGCAGGCTTCGG
GTATTGCTCTTATTCAGGAAGAGTGTGCCGGCAGTTACGGCAGGAGAATAAGACGGGTTGTTATCGAATCGAGGGGGTTA
TGGAGTTTTCTTGCCCCGCAGGCACCGTTGATGTGCAATAATTCCGGCAGTACCATGCGAATGTTTGCCGGTATTCTTGC
AGCTCAGCCTTTTGAGAGCGTTCTTGAAGGCGACAGTTCACTCATGAAGCGGCCGATGAATCGTGTTGCCGATCCCTTGC
GGCAGATGGGCGCCCAGGTAGAGCTCTCTTTTTCGGGGACCGCGCCGATTCGGATACAGGGCACAAAAGATCTTCACTCG
CTTGAATACCGTCTTCCTGTATCTTCAGCACAGGTTAAGTCGCTTGTTGCCTTTGCTGCGCTTCATGCCGACGGCCAAAC
CCGCATTATCGAACCGATTCGATCGCGCGACCATACCGAGCTGATGCTTGGTCTTGAAACCATCGATCAGCCGAATGGCG
AGCGGGTGATTATTGTTCCCGGCCGTAAACGTATCGAATCAAAGCCGTTTTATATCCCCGCTGATCCTTCCGCAGCCTGC
TTTATCGTAGCGCTTGCGCTGCTTGCAAAAGGTTCGGACATTATCATCAGGGATCTCTGTCTCAATCCTACCAGAACCGG
ATACCTTGCTATTCTTGCAGGCGCGGGCGCAGGTATATCGGTAGAAAACAGTCGTGTTATCGGTGGTGAAGCAATCGGTG
ACGTTCTTGTGCATAGCGAGGGCGAACTCAACTCGTTAGTTATCAGCGATCCTCATGAGGTTGCCAATGTTATTGACGAA
ATTCCGATGCTTGCCGTTTTGTCGGCCTTTTCGTCCGGTCGCTTTGAGTTGCATCATGCTGCGGAACTCAGAACCAAGGA
GAGCGACAGGATTGATGCTCTTGTCGTTAATCTTGAGCGTCTCGGTTTTCAGTGCGAGCAGTACCCTGATGGATTCAAGG
TCAATGGCCGCATCGCGATGCCGAAGGGAGTTGTTTCCATTGAGAGTTTTGATGATCACAGGATTGCCATGAGTTTTGCT
ATTGCAGGAAAAGCAACGGGCGTTGACCTTGCTATTTCAGATATCGGCGTGGTGGGGGTGTCGTTTCCAAACTTTTTCGA
GATTATCGAGAGCCTCGAAGTCTGA

Upstream 100 bases:

>100_bases
GAAGAACGCAATTCATAGAAGTCGGGTCTGATAATGATGTTAAAAGCAACTCCTTTAAATGGGAGTTGCTTTTTTTTTGT
TAAAGAAAATTAACGGTCAA

Downstream 100 bases:

>100_bases
TGACGTTTTTTTAACGGGCAGCACCGAAAGCCTGAATATGTTCAAGCAGCAGCGCGTTGAACCGCGCGGGTTGTTCCATG
TTCGAAAGGTGGGCTGCTTC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSVFKGEVTALPPDKSISHRAALIGALSDGTTEIVNFSGGFDNQSTLAVLQASGIALIQEECAGSYGRRIRRVVIESRGL
WSFLAPQAPLMCNNSGSTMRMFAGILAAQPFESVLEGDSSLMKRPMNRVADPLRQMGAQVELSFSGTAPIRIQGTKDLHS
LEYRLPVSSAQVKSLVAFAALHADGQTRIIEPIRSRDHTELMLGLETIDQPNGERVIIVPGRKRIESKPFYIPADPSAAC
FIVALALLAKGSDIIIRDLCLNPTRTGYLAILAGAGAGISVENSRVIGGEAIGDVLVHSEGELNSLVISDPHEVANVIDE
IPMLAVLSAFSSGRFELHHAAELRTKESDRIDALVVNLERLGFQCEQYPDGFKVNGRIAMPKGVVSIESFDDHRIAMSFA
IAGKATGVDLAISDIGVVGVSFPNFFEIIESLEV

Sequences:

>Translated_434_residues
MSVFKGEVTALPPDKSISHRAALIGALSDGTTEIVNFSGGFDNQSTLAVLQASGIALIQEECAGSYGRRIRRVVIESRGL
WSFLAPQAPLMCNNSGSTMRMFAGILAAQPFESVLEGDSSLMKRPMNRVADPLRQMGAQVELSFSGTAPIRIQGTKDLHS
LEYRLPVSSAQVKSLVAFAALHADGQTRIIEPIRSRDHTELMLGLETIDQPNGERVIIVPGRKRIESKPFYIPADPSAAC
FIVALALLAKGSDIIIRDLCLNPTRTGYLAILAGAGAGISVENSRVIGGEAIGDVLVHSEGELNSLVISDPHEVANVIDE
IPMLAVLSAFSSGRFELHHAAELRTKESDRIDALVVNLERLGFQCEQYPDGFKVNGRIAMPKGVVSIESFDDHRIAMSFA
IAGKATGVDLAISDIGVVGVSFPNFFEIIESLEV
>Mature_433_residues
SVFKGEVTALPPDKSISHRAALIGALSDGTTEIVNFSGGFDNQSTLAVLQASGIALIQEECAGSYGRRIRRVVIESRGLW
SFLAPQAPLMCNNSGSTMRMFAGILAAQPFESVLEGDSSLMKRPMNRVADPLRQMGAQVELSFSGTAPIRIQGTKDLHSL
EYRLPVSSAQVKSLVAFAALHADGQTRIIEPIRSRDHTELMLGLETIDQPNGERVIIVPGRKRIESKPFYIPADPSAACF
IVALALLAKGSDIIIRDLCLNPTRTGYLAILAGAGAGISVENSRVIGGEAIGDVLVHSEGELNSLVISDPHEVANVIDEI
PMLAVLSAFSSGRFELHHAAELRTKESDRIDALVVNLERLGFQCEQYPDGFKVNGRIAMPKGVVSIESFDDHRIAMSFAI
AGKATGVDLAISDIGVVGVSFPNFFEIIESLEV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=430, Percent_Identity=25.3488372093023, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=460, Percent_Identity=24.5652173913043, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_CHLPD (A1BIP2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912693.1
- ProteinModelPortal:   A1BIP2
- SMR:   A1BIP2
- STRING:   A1BIP2
- GeneID:   4568693
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2277
- NMPDR:   fig|290317.7.peg.2389
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46578; Mature: 46447

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFKGEVTALPPDKSISHRAALIGALSDGTTEIVNFSGGFDNQSTLAVLQASGIALIQE
CCCCCCCEEECCCCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCEEEHH
ECAGSYGRRIRRVVIESRGLWSFLAPQAPLMCNNSGSTMRMFAGILAAQPFESVLEGDSS
HHCCHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCCHHHHHHHHHHCCCHHHHHCCCHH
LMKRPMNRVADPLRQMGAQVELSFSGTAPIRIQGTKDLHSLEYRLPVSSAQVKSLVAFAA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCHHEEEECCCCHHHHHHHHHHHH
LHADGQTRIIEPIRSRDHTELMLGLETIDQPNGERVIIVPGRKRIESKPFYIPADPSAAC
HCCCCCHHHHHHHHCCCCCEEEEEHHHCCCCCCCEEEEECCCHHCCCCCEEEECCCCHHH
FIVALALLAKGSDIIIRDLCLNPTRTGYLAILAGAGAGISVENSRVIGGEAIGDVLVHSE
HHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCEEECCHHHHHHEEECC
GELNSLVISDPHEVANVIDEIPMLAVLSAFSSGRFELHHAAELRTKESDRIDALVVNLER
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCHHHHEEEHHH
LGFQCEQYPDGFKVNGRIAMPKGVVSIESFDDHRIAMSFAIAGKATGVDLAISDIGVVGV
HCCCHHCCCCCEEECCEEECCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEECCEEEEC
SFPNFFEIIESLEV
CCHHHHHHHHHHCC
>Mature Secondary Structure 
SVFKGEVTALPPDKSISHRAALIGALSDGTTEIVNFSGGFDNQSTLAVLQASGIALIQE
CCCCCCEEECCCCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCEEEHH
ECAGSYGRRIRRVVIESRGLWSFLAPQAPLMCNNSGSTMRMFAGILAAQPFESVLEGDSS
HHCCHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCCHHHHHHHHHHCCCHHHHHCCCHH
LMKRPMNRVADPLRQMGAQVELSFSGTAPIRIQGTKDLHSLEYRLPVSSAQVKSLVAFAA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCHHEEEECCCCHHHHHHHHHHHH
LHADGQTRIIEPIRSRDHTELMLGLETIDQPNGERVIIVPGRKRIESKPFYIPADPSAAC
HCCCCCHHHHHHHHCCCCCEEEEEHHHCCCCCCCEEEEECCCHHCCCCCEEEECCCCHHH
FIVALALLAKGSDIIIRDLCLNPTRTGYLAILAGAGAGISVENSRVIGGEAIGDVLVHSE
HHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCEEECCHHHHHHEEECC
GELNSLVISDPHEVANVIDEIPMLAVLSAFSSGRFELHHAAELRTKESDRIDALVVNLER
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCHHHHEEEHHH
LGFQCEQYPDGFKVNGRIAMPKGVVSIESFDDHRIAMSFAIAGKATGVDLAISDIGVVGV
HCCCHHCCCCCEEECCEEECCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEECCEEEEC
SFPNFFEIIESLEV
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA